A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 23, 2021

Primary Completion Date

March 5, 2025

Study Completion Date

March 5, 2025

Conditions
Non-Small Cell Lung Cancer (NSCLC)
Interventions
DRUG

Atezolizumab

Atezolizumab 1200 mg will be administered by intravenous (IV) infusion on Day 1 of each 21-day cycle.

DRUG

Tiragolumab

Tiragolumab 600 mg will be administered by IV infusion on Day 1 of each 21-day cycle.

DRUG

Carboplatin

Carboplatin at initial target area under the concentration curve (AUC) of 5 or 6 mg/mL/min will be administered by IV infusion on Day 1 of each 21-day cycle.

DRUG

Cisplatin

Cisplatin at 75 mg/m\^2 will be administered by IV infusion on Day 1 of each 21-day cycle.

DRUG

Pemetrexed

Pemetrexed at 500 mg/m\^2 will be administered by IV infusion on Day 1 of each 21-day cycle.

DRUG

Gemcitabine

Gemcitabine at 1000 or 1250 mg/m\^2 will be administered by IV infusion on Days 1 and 8 of each 21-day cycle.

DRUG

Paclitaxel

Paclitaxel at 175 or 200 mg/m\^2 will be administered by IV infusion on Day 1 of each 21-day cycle.

Trial Locations (22)

3000

Peter Maccallum Cancer Institute, Melbourne

4575

Sunshine Coast University Hospital, Birtinya

5404

Kantonsspital Baden, Baden

7000

Kantonsspital Graubünden Medizin Onkologie, Chur

8091

UniversitätsSpital Zürich, Zurich

8401

Kantonsspital Winterthur, Winterthur

9007

Kantonsspital St. Gallen, Sankt Gallen

10016

NYU Cancer Center, New York

11501

Winthrop Univ Hospital, Mineola

15006

Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña

16247

St. Vincent's Hospital, Gyeonggi-do

28041

Hospital Universitario 12 de Octubre, Madrid

28222

Hospital Universitario Puerta de Hierro, Majadahonda

63110

Washington University School of Medicine, St Louis

90033

University of Southern California, Los Angeles

91010

City of Hope Cancer Center, Duarte

92618

City of Hope at Irvine Lennar, Irvine

10032-3725

Columbia University, New York

03722

Severance Hospital, Yonsei University Health System, Seoul

08908

ICO L'Hospitalet, L'Hospitalet de Llobregat

08208

Corporacio Sanitaria Parc Tauli, Sabadell

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY