Efficacy and Safety of EUS-Guided Therapy Versus BRTO for Gastric Varices With Shunt

CompletedOBSERVATIONAL
Enrollment

104

Participants

Timeline

Start Date

October 1, 2020

Primary Completion Date

December 31, 2021

Study Completion Date

December 31, 2021

Conditions
Portal HypertensionLiver CirrhosisGastric VarixPortosystemic Shunt
Interventions
PROCEDURE

EUS-guided coil embolization combined with endoscopic cyanoacrylate injection

(1) Standard diagnostic endoscopy was first performed. Fundal varices were assessed using the classification of Sarin's. (2) intraluminal water filling of the gastric fundus to use EUS to assess the anatomy of gastric varices, observe the blood flow, scan the portal venous system, left renal vein, confirm the location of the shunt, and measure the diameter of the shunt. (3) Punctured the gastric fundal variceal vein at the lower esophagus near the cardia and placed the coil into the shunt and immediately injected with sclerosant and cyanoacrylate under the guidance of EUS. (4) Sclerosant and cyanoacrylate were injected into the gastric fundal varices by a sandwich method (cyanoacrylate, sclerosant and cyanoacrylate) via endoscope. (5) After the injection, use color Doppler ultrasound to observe the blood flow in the variceal veins to evaluate the embolization effect.

PROCEDURE

balloon-occluded retrograde transvenous obliteration

(1)A balloon occlusive catheter was inserted into the shunt via the right femoral vein. (2)Investigators performed angiography to evaluate the size and location of GV and the shunt during balloon occlusion. Shunt was occluded by Fogarty balloon. The diameter of the balloon was chosen according to the diameter of shunt. (3)Then investigators injected sclerosant into the portosystemic shunt. (4)Finally, the balloon left in place for 24 hours was gradually deflated when complete occlusion of blood flow of the target shunt was achieved.

Trial Locations (1)

430060

Mingkai Chen, Wuhan

All Listed Sponsors
lead

Renmin Hospital of Wuhan University

OTHER

NCT04828369 - Efficacy and Safety of EUS-Guided Therapy Versus BRTO for Gastric Varices With Shunt | Biotech Hunter | Biotech Hunter