54
Participants
Start Date
July 14, 2021
Primary Completion Date
November 11, 2024
Study Completion Date
November 11, 2024
RO7122290
RO7122290 will be administered using a QW (Part I) or Q3W (Part I or Part II) schedule in combination with 100 mg cibisatamab Q3W with obinutuzumab pre-treatment. The maximum dose of RO7122290 to be explored in combination with cibisatamab with obinutuzumab pre-treatment in this study is 500 mg for the QW dosing interval (Part I) or 1500 mg for the Q3W dosing interval (Part I or Part II).
Cibisatamab
Cibisatamab will be administered to participants at a fixed dose of 100 mg Q3W (100 mg on Day 1 of each 21-day cycle).
Obinutuzumab
"Obinutuzumab will be administered (IV) as pre-treatment on Day - 8/- 7 (split dose) or~\- 8 (single dose) prior to C1D1 of cibisatamab and as re-treatment every 6 months if the participant is still receiving cibisatamab"
Rigshospitalet, København Ø
Clinica Universidad de Navarra Madrid, Madrid
Fundacion Jimenez Diaz, Madrid
Hospital Universitario 12 de Octubre, Madrid
Centro Integral Oncologico Clara Campal, Madrid
Clinica Universitaria de Navarra, Pamplona
NKI/AvL, Amsterdam
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Hospital del Mar, Barcelona
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona
Christie Hospital NHS Trust, Manchester
Churchill Hospital, Oxford
Hoffmann-La Roche
INDUSTRY