Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

899

Participants

Timeline

Start Date

May 11, 2021

Primary Completion Date

September 1, 2026

Study Completion Date

November 1, 2027

Conditions
Diffuse Large B-cell Lymphoma
Interventions
DRUG

Tafasitamab

Tafasitamab IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Lenalidomide

Lenalidomide PO will be administered as per the schedule specified in the respective arm.

DRUG

Rituximab

Rituximab IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Cyclophosphamide

Cyclophosphamide IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Doxorubicin

Doxorubicin IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Vincristine

Vincristine IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Prednisone

Prednisone PO will be administered as per the schedule specified in the respective arm.

DRUG

Tafasitamab placebo

0.9% saline solution IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Lenalidomide placebo

Placebo matching to lenalidomide PO will be administered as per the schedule specified in the respective arm.

Trial Locations (307)

613

Morphosys Research Site, Chiayi City

1000

MorphoSys Research Site, Manila

1023

MorphoSys Research Site, Auckland

1085

MorphoSys Research Site, Budapest

1090

MorphoSys Research Site, Vienna

1112

MorphoSys Research Site, Quezon City

1140

MorphoSys Research Site, Vienna

1605

MorphoSys Research Site, Pasig

2000

MorphoSys Research Site, Rosario

2050

MorphoSys Research Site, Sydney

2145

MorphoSys Research Site, Sydney

2217

MorphoSys Research Site, Kogarah

2250

MorphoSys Research Site, Gosford

2298

MorphoSys Research Site, Waratah

2500

MorphoSys Research Site, Wollongong

2605

MorphoSys Research Site, Canberra

2747

MorphoSys Research Site, Kingswood

3021

MorphoSys Research Site, St Albans

3065

MorphoSys Research Site, Melbourne

3084

MorphoSys Research Site, Melbourne

3100

MorphoSys Research Site, Sankt Pölten

3121

MorphoSys Research Site, Richmond

3144

MorphoSys Research Site, Malvern

3168

MorphoSys Research Site, Clayton

3220

MorphoSys Research Site, Geelong

3353

MorphoSys Research Site, Ballarat

4010

MorphoSys Research Site, Linz

4021

MorphoSys Research Site, Linz

4032

MorphoSys Research Site, Debrecen

4101

MorphoSys Research Site, Brisbane

4120

MorphoSys Research Site, Greenslopes

4575

MorphoSys Research Site, Birtinya

4817

MorphoSys Research Site, Townsville

4924

MorphoSys Research Site, Busan

5000

MorphoSys Research Site, Adelaide

6000

MorphoSys Research Site, Perth

6009

MorphoSys Research Site, Nedlands

6020

MorphoSys Research Site, Innsbruck

6150

MorphoSys Research Site, Perth

6830

MorphoSys Research Site, Rankweil

7000

MorphoSys Research Site, Hobart

8324

MorphoSys Research Site, Cipolletti

8833

MorphoSys Research Site, Wahroonga

9024

MorphoSys Research Site, Győr

10043

MorphoSys Research Site, Orbassano

10060

MorphoSys Research Site, Candiolo

10126

MorphoSys Research Site, Turin

10400

MorphoSys Research Site, Bangkok

10408

MorphoSys Research Site, Goyang-si

10500

Morphosys Research Site, Bangkok

10967

MorphoSys Research Site, Berlin

10990

MorphoSys Research Site, George Town

11407

MorphoSys Research Site, Jerez de la Frontera

12120

MorphoSys Research Site, Pathum Thani

13353

MorphoSys Research Site, Berlin

13385

MorphoSys Research Site, Marseille

14029

Morphosys Research Site, Chernihiv

14033

MorphoSys Research Site, Amiens

14263

MorphoSys Research Site, Buffalo

14642

MorphoSys Research Site, Rochester

15121

MorphoSys Research Site, Siena

16132

MorphoSys Research Site, Genoa

16150

MorphoSys Research Site, Kota Bharu

17007

MorphoSys Research Site, Girona

18009

Morphosys Research Site, Cherkasy

20001

MorphoSys Research Site, Valledupar

20089

MorphoSys Research Site, Rozzano

20141

MorphoSys Research Site, Milan

20155

MorphoSys Research Site, Gainesville

21044

MorphoSys Research Site, Columbia

21204

MorphoSys Research Site, Kamenitz

21237

MorphoSys Research Site, Baltimore

23456

MorphoSys Research Site, Virginia Beach

23538

MorphoSys Research Site, Lübeck

24014

MorphoSys Research Site, Roanoke

24127

MorphoSys Research Site, Bergamo

25100

MorphoSys Research Site, Kuantan

25123

MorphoSys Research Site, Brescia

27003

MorphoSys Research Site, Lugo

27100

MorphoSys Research Site, Pavia

28034

MorphoSys Research Site, Madrid

28040

MorphoSys Research Site, Madrid

28041

MorphoSys Research Site, Madrid

28050

MorphoSys Research Site, Madrid

28100

MorphoSys Research Site, Novara

28223

MorphoSys Research Site, Madrid

29107

MorphoSys Research Site, Quimper

30450

MorphoSys Research Site, Ipoh

31008

MorphoSys Research Site, Pamplona

31096

MorphoSys Research Site, Haifa

32224

MorphoSys Research Site, Jacksonville

33074

MorphoSys Research Site, Bordeaux

33076

MorphoSys Research Site, Bordeaux

33098

MorphoSys Research Site, Paderborn

33343

MorphoSys Research Site, Mersin

34125

MorphoSys Research Site, Kassel

34129

MorphoSys Research Site, Trieste

35043

MorphoSys Research Site, Marburg

35100

MorphoSys Research Site, Izmir

35128

MorphoSys Research Site, Padua

36526

MorphoSys Research Site, Daphne

37007

MorphoSys Research Site, Salamanca

37075

MorphoSys Research Site, Göttingen

37203

MorphoSys Research Site, Nashville

37404

MorphoSys Research Site, Chattanooga

38138

MorphoSys Research Site, Germantown

38700

MorphoSys Research Site, La Tronche

39120

MorphoSys Research Site, Magdeburg

40000

Morphosys Research Site, Khon Kaen

40241

MorphoSys Research Site, Louisville

40447

Morphosys Research Site, Taichung

40705

MorphoSys Research Site, Taichung

41009

MorphoSys Research Site, Seville

41013

MorphoSys Research Site, Seville

41014

MorphoSys Research Site, Seville

41380

MorphoSys Research Site, İzmit

42270

MorphoSys Research Site, Saint-Priest-en-Jarez

42283

MorphoSys Research Site, Wuppertal

42415

MorphoSys Research Site, Daegu

42472

MorphoSys Research Site, Daegu

42601

MorphoSys Research Site, Daegu

44093

MorphoSys Research Site, Nantes

44280

MorphoSys Research Site, Malatya

44718

MorphoSys Research Site, Canton

45242

MorphoSys Research Site, Cincinnati

46017

MorphoSys Research Site, Valencia

47014

MorphoSys Research Site, Forlì

47392

MorphoSys Research Site, Busan

47500

MorphoSys Research Site, Petaling Jaya

MorphoSys Research Site, Subang Jaya

47923

MorphoSys Research Site, Rimini

48121

MorphoSys Research Site, Ravenna

48149

MorphoSys Research Site, Münster

48202

MorphoSys Research Site, Detroit

49100

MorphoSys Research Site, Petah Tikva

49201

MorphoSys Research Site, Busan

49267

MorphoSys Research Site, Busan

50200

Morphosys Research Site, Chiang Mai

50612

MorphoSys Research Site, Yangsan

52074

MorphoSys Research Site, Aachen

53100

MorphoSys Research Site, Siena

53127

MorphoSys Research Site, Bonn

54449

MorphoSys Research Site, Marshfield

55131

MorphoSys Research Site, Mainz

55426

MorphoSys Research Site, Minneapolis

55905

MorphoSys Research Site, Rochester

56017

MorphoSys Research Site, Vannes

59020

MorphoSys Research Site, Lille

59100

MorphoSys Research Site, Kuala Lumpur

61070

Morphosys Research Site, Kharkiv

64132

MorphoSys Research Site, Kansas City

65191

MorphoSys Research Site, Wiesbaden

65199

MorphoSys Research Site, Tübingen

67214

MorphoSys Research Site, Wichita

68000

MorphoSys Research Site, Ampang

71004

MorphoSys Research Site, Tainan City

72037

MorphoSys Research Site, Le Mans

73039

MorphoSys Research Site, Tricase

73100

MorphoSys Research Site, Lecce

75020

MorphoSys Research Site, Denison

75702

MorphoSys Research Site, Tyler

76022

MorphoSys Research Site, Bedford

76104

MorphoSys Research Site, Fort Worth

77030

MorphoSys Research Site, Houston

78503

MorphoSys Research Site, McAllen

78745

MorphoSys Research Site, Austin

80012

MorphoSys Research Site, Aurora

80100

MorphoSys Research Site, Johor Bahru

81675

MorphoSys Research Site, Munich

81737

MorphoSys Research Site, Munich

83310

MorphoSys Research Site, Bratislava

84112

MorphoSys Research Site, Salt Lake City

84405

MorphoSys Research Site, Ogden

86021

MorphoSys Research Site, Poitiers

86156

MorphoSys Research Site, Augsburg

87042

MorphoSys Research Site, Limoges

90017

MorphoSys Research Site, Los Angeles

90146

MorphoSys Research Site, Palermo

90603

MorphoSys Research Site, Whittier

90710

MorphoSys Research Site, Harbor City

92123

MorphoSys Research Site, San Diego

92801

MorphoSys Research Site, Anaheim

93586

MorphoSys Research Site, Kuching

93611

MorphoSys Research Site, Clovis

95123

MorphoSys Research Site, Catania

96813

MorphoSys Research Site, Honolulu

97080

MorphoSys Research Site, Würzburg

97401

MorphoSys Research Site, Eugene

98405

MorphoSys Research Site, Tacoma

98502

MorphoSys Research Site, Olympia

100226

MorphoSys Research Site, Taipei

197341

MorphoSys Research Site, Saint Petersburg

197758

MorphoSys Research Site, Saint Petersburg

420029

MorphoSys Research Site, Kazan'

500366

MorphoSys Research Site, Brasov

630087

MorphoSys Research Site, Novosibirsk

700483

MorphoSys Research Site, Iași

833401

MorphoSys Research Site, Kaohsiung City

6423906

MorphoSys Research Site, Tel Aviv

8410101

MorphoSys Research Site, Beersheba

9112001

MorphoSys Research Site, Jerusalem

92834-4138

MorphoSys Research Site, Fullerton

40536-0293

MorphoSys Research Site, Lexington

20817-7847

MorphoSys Research Site, Bethesda

03755

MorphoSys Research Site, Lebanon

07932

MorphoSys Research Site, Florham Park

17822-4910

MorphoSys Research Site, Danville

C1118AAT

MorphoSys Research Site, Buenos Aires

C1181ACH

MorphoSys Research Site, Buenos Aires

T4000IVL

MorphoSys Research Site, San Miguel de Tucumán

VIC 3199

MorphoSys Research Site, Frankston

QLD 4217

MorphoSys Research Site, Gold Coast

TAS 7250

MorphoSys Research Site, Launceston

B3H 2A7

MorphoSys Research Site, Halifax

N6A 5W9

MorphoSys Research Site, London

H3T 1E2

MorphoSys Research Site, Montreal

S7N 4H4

MorphoSys Research Site, Saskatoon

J1G 2E8

MorphoSys Research Site, Sherbrooke

050034

MorphoSys Research Site, Medellín

625 00

MorphoSys Research Site, Brno

500 05

MorphoSys Research Site, Hradec Králové

775 20

MorphoSys Research Site, Olomouc

708 52

MorphoSys Research Site, Ostrava

100 34

MorphoSys Research Site, Prague

110 00

MorphoSys Research Site, Prague

150 06

MorphoSys Research Site, Prague

Unknown

Morphosys Research Site, Caen

Morphosys Research Site, Bordeau

Morphosys Research Site, Le Chesnay

MorphoSys Research Site, Vandœuvre-lès-Nancy

Morphosys Research Site, Berlin

Morphosys Research Site, Nyíregyháza

MorphoSys Research Site, Dublin

MorphoSys Research Site, Limerick

Morphosys Research Site, Ramat Gan

Morphosys Research Site, Lodz

Morphosys Research Site, Bucharest

Morphosys Research Site, Cluj-Napoca

Morphosys Research Site, Craiova

Morphosys Research Site, Moscow

Morphosys Research Site, Petrozavodsk

Morphosys Research Site, Saint Petersburg

Morphosys research site, Ufa

Morphosys Research Site, Novi Sad

MorphoSys Research Site, Incheon

MorphoSys Research Site, Jinju

Morphosys Research Site, Chang-hua

Morphosys Research Site, Hualien City

Morphosys Research Site, Kaohsiung City

Morphosys Research Site, New Taipei City

Morphsys Research Site, Taoyuan District

MorphoSys Research Site, Ankara

09116

MorphoSys Research Site, Chemnitz

03048

MorphoSys Research Site, Cottbus

06120

MorphoSys Research Site, Halle

D-74078

MorphoSys Research Site, Heilbronn

07747

MorphoSys Research Site, Jena

H-1122

MorphoSys Research Site, Budapest

H-7624

MorphoSys Research Site, Pécs

05100

MorphoSys Research Site, Terni

810-8563

MorphoSys Research Site, Fukuoka

500-8513

MorphoSys Research Site, Gifu

311-3193

MorphoSys Research Site, Ibaraki

259-1193

MorphoSys Research Site, Isehara

890-8520

MorphoSys Research Site, Kagoshima

466-8650

MorphoSys Research Site, Nagoya

286-8520

MorphoSys Research Site, Narita-shi

701-1192

MorphoSys Research Site, Okayama

565-0871

MorphoSys Research Site, Osaka

589-8511

MorphoSys Research Site, Osakasayama-shi

003-0804

MorphoSys Research Site, Sapporo

190-0014

MorphoSys Research Site, Tachikawa

113-8603

MorphoSys Research Site, Tokyo

142-8666

MorphoSys Research Site, Tokyo

162-8666

MorphoSys Research Site, Tokyo

514-8507

MorphoSys Research Site, Tsu

05460

MorphoSys Research Site, Alor Star

02-781

MorphoSys Research Site, Warsaw

050098

MorphoSys Research Site, Bucharest

11 000

MorphoSys Research Site, Belgrade

11 080

MorphoSys Research Site, Belgrade

04166

MorphoSys Research Site, Košice

561-712

MorphoSys Research Site, Jeonju

03080

MorphoSys Research Site, Seoul

03181

MorphoSys Research Site, Seoul

037222

MorphoSys Research Site, Seoul

05505

MorphoSys Research Site, Seoul

07345

MorphoSys Research Site, Seoul

07985

MorphoSys Research Site, Seoul

08916

MorphoSys Research Site, Badalona

08035

MorphoSys Research Site, Barcelona

08908

MorphoSys Research Site, Barcelona

01009

MorphoSys Research Site, Vitoria-Gasteiz

06590

MorphoSys Research Site, Ankara

03022

Morphosys Research Site, Kyiv

03115

MorphoSys Research Site, Kyiv

03680

Morphosys Research Site, Kyiv

AB25 2ZN

MorphoSys Research Site, Aberdeen

BA1 3NG

MorphoSys Research Site, Bath

B15 2TH

MorphoSys Research Site, Birmingham

BS2 8ED

MorphoSys Research Site, Bristol

EC1M 6BQ

MorphoSys Research Site, London

SM2 5PT

MorphoSys Research Site, London

SW3 6JJ

Morphosys Research Site, London

NG5 1PB

MorphoSys Research Site, Nottingham

SW17 0QT

MorphoSys Research Site, Sutton

WV10 0QP

MorphoSys Research Site, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY