Placental Transfusion Effect on Hemodynamics of Premature Newborns

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

57

Participants

Timeline

Start Date

January 1, 2021

Primary Completion Date

September 1, 2021

Study Completion Date

October 1, 2021

Conditions
Pre-Term
Interventions
BIOLOGICAL

Intact umbilical cord milking (I-UCM)

Umblical cord milking will be performed by holding the newborn at or ∼20 cm below the level of the placenta. The cord will be pinched between 2 fingers as close to the placenta as possible and milked toward the infant over a 2-second duration. The cord will then be released and allowed to refill with blood for a brief 1- to 2-second pause between each milking motion. This will be repeated for 2-4 times. After completion, the cord will be clamped, and the neonate will be handed to the resuscitation team.

BIOLOGICAL

Cut-umbilical cord milking(C-UCM)

This technique involves clamping and cutting a long segment of the umbilical cord immediately at birth and passing the baby and the long cord to the pediatric provider, called C-UCM untwists the cord and milks the entire contents into the baby. Milking the cord 2-3 times before clamping may produce a similar placental transfusion as C-UCM.

BIOLOGICAL

Delayed Cord Clamping (DCC)

Infants placed on the maternal abdomen or at the introitus below the level of placenta and waiting at least 30- to 60 seconds before clamping the cord.

Trial Locations (1)

21131

Neonatal Intensive Care Unit (NICU) of Alexandria University Maternity Hospital., Alexandria

All Listed Sponsors
lead

Marwa Mohamed Farag

OTHER

NCT04811872 - Placental Transfusion Effect on Hemodynamics of Premature Newborns | Biotech Hunter | Biotech Hunter