321
Participants
Start Date
March 18, 2022
Primary Completion Date
April 3, 2025
Study Completion Date
April 3, 2025
Sotatercept
Sotatercept (ACE-011) is a recombinant fusion protein consisting of the extracellular domain of the human activin receptor type IIA linked to the Fc piece of human IgG1
Placebo
Placebo
La Sapienza-Università di Roma-Policlinico Umberto I ( Site 2402), Roma
National Cheng Kung University Hospital ( Site 3703), Tainan City
Hopital Erasme ( Site 1402), Anderlecht
Medizinische Universitat Wien ( Site 2001), Vienna
Instituto de Investigaciones Clinicas Quilmes ( Site 1903), Quilmes
Hospital Provincial del Centenario ( Site 1912), Rosario
Royal Prince Alfred Hospital ( Site 1106), Camperdown
Rigshospitalet ( Site 3802), København Ø
John Hunter Hospital ( Site 1101), Newcastle
UZ Gasthuisberg ( Site 1401), Leuven
Waikato District Health Board ( Site 2702), Hamilton
Ordensklinikum Linz GmbH Elisabethinen ( Site 2002), Linz
Prince Charles Hospital ( Site 1104), Chermside
Princess Alexandra Hospital ( Site 1108), Woolloongabba
Royal Adelaide Hospital ( Site 1109), Adelaide
Medizinische Universitat Innsbruck ( Site 2004), Innsbruck
Fiona Stanley Hospital ( Site 1103), Murdoch
Royal Hobart Hospital ( Site 1107), Hobart
Medizinische Universität Graz ( Site 2003), Graz
UniversitätsSpital Zürich ( Site 3301), Zurich
Aarhus Universitetshospital, Skejby ( Site 3801), Aarhus
Klinicki Bolnicki Centar Zagreb ( Site 3902), Zagreb
Clinical Center of Serbia ( Site 2901), Belgrade
CHU Caen Normandie ( Site 1325), Caen
DRK Kliniken Berlin Westend ( Site 1507), Berlin
University Clinical Center Nis ( Site 2904), Niš
Ospedale S. Giuseppe Multimedica ( Site 2403), Milan
Azienda Ospedaliera San Gerardo di Monza ( Site 2406), Monza
University Hospital Centre Split city ( Site 3901), Split
Institute for pulmonary diseases of Vojvodina ( Site 2906), Kamenitz
Gachon University Gil Medical Center ( Site 3103), Namdong-Gu
Skanes Universitetssjukhus Lund ( Site 3203), Lund
CHU de Besancon ( Site 1303), Besançon
University of North Carolina at Chapel Hill ( Site 1042), Chapel Hill
Hospital Universitario 12 de Octubre ( Site 1603), Madrid
Hospital Universitario La Paz ( Site 1610), Madrid
Hospital Universitario Puerta de Hierro (Majadahonda) ( Site 1604), Majadahonda
Hopital Cavale Blanche ( Site 1314), Brest
Medizinische Hochschule Hannover ( Site 1505), Hanover
CHU de Toulouse - Hopital Larrey ( Site 1315), Toulouse
AdventHealth Medical Group Advanced Lung Disease ( Site 1058), Orlando
Hopital Haut Leveque ( Site 1312), Bordeaux
Clinical Center Kragujevac ( Site 2905), Kragujevac
Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) ( Site 2405), Trieste
Universitaetsklinikum Giessen und Marburg GmbH ( Site 1512), Bad Oeynhausen
C.H.U. de Tours - Hopital Bretonneau ( Site 1310), Tours
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca ( Site 1608), Salamanca
Vanderbilt University Medical Center ( Site 1027), Nashville
Hospital Universitario Marques de Valdecilla ( Site 1601), Santander
China Medical University Hospital ( Site 3701), Taichung
Centre Hospitalier Universitaire de Saint-Etienne ( Site 1302), Saint-Priest-en-Jarez
Hopital Nord Laennec ( Site 1309), Nantes
The Cleveland Clinic Foundation Taussig Cancer Center ( Site 1065), Cleveland
Hospital Virgen de la Salud ( Site 1607), Toledo
The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital ( Site 1001), Cincinnati
University of Cincinnati ( Site 1035), Cincinnati
University of Michigan ( Site 1011), Ann Arbor
CHU Angers ( Site 1313), Angers
Centro Cardiovascular Colombiano Clínica Santa María Clínica Cardio VID ( Site 3402), Medellín
Uniklinik Köln ( Site 1511), Cologne
University of Iowa Hospital and Clinics ( Site 1050), Iowa City
Sheba Medical Center ( Site 1701), Tel Litwinsky
C.H.U. de Nancy. Hopital de Brabois Adultes ( Site 1308), Vandœuvre-lès-Nancy
Chonnam National University Hospital ( Site 3105), Gwangju
Washington University School of Medicine ( Site 1022), St Louis
University of Kansas Medical Center ( Site 1020), Kansas City
Universitatsklinikum des Saarlandes ( Site 1513), Homburg
Hopitaux Universitaires de Strasbourg ( Site 1307), Strasbourg
Hopital Louis Pradel ( Site 1317), Lyon
Universitaetsklinikum Heidelberg ( Site 1509), Heidelberg
University of Texas Southwestern Medical Center ( Site 1038), Dallas
University of Colorado Hospital ( Site 1013), Aurora
Azienda Ospedaliera R. N. V. Monaldi ( Site 2407), Napoli
Krankenhaus Neuwittelsbach ( Site 1510), Munich
Kaohsiung Veterans General Hospital ( Site 3702), Kaohsiung City
Arizona Pulmonary Specialists ( Site 1010), Scottsdale
University of Arizona ( Site 1006), Tucson
CHU de Poitiers ( Site 1316), Poitiers
University of New Mexico, Health Sciences Center ( Site 1048), Albuquerque
UCLA Medical Center ( Site 1068), Los Angeles
Norrlands Universitetssjukhus ( Site 3205), Umeå
University of California San Diego ( Site 1002), La Jolla
University of California Irvine ( Site 1086), Orange
Universitaetsklinik Regensburg ( Site 1503), Regensburg
CHU - Hopital de Bicetre ( Site 1304), Le Kremlin-Bicêtre
University of California Davis Medical Center ( Site 1064), Sherman Oaks
Oregon Health & Science University ( Site 1054), Portland
Fundacion Neumologica Colombiana ( Site 3403), Bogota
Fundacion Valle Del Lili ( Site 3401), Santiago de Cali
Centro Medico Imbanaco de Cali S.A ( Site 3404), Santiago de Cali
Lady Davis Carmel Medical Center ( Site 1705), Haifa
Assuta Ashdod Medical Center ( Site 1710), Ashdod
Hadassah Medical Center ( Site 1711), Jerusalem
Santa Barbara Pulmonary Associates ( Site 1060), Santa Barbara
Johns Hopkins Hospital ( Site 1036), Baltimore
Tufts Medical Center - PPDS ( Site 1014), Boston
Boston Medical Center ( Site 1012), Boston
NYU Langone Health ( Site 1052), New York
Nazih Zuhdi Transplantation Institute ( Site 1084), Oklahoma City
Medical University of South Carolina ( Site 1003), Charleston
University of Utah ( Site 1049), Salt Lake City
Cardiologia Palermo ( Site 1911), Ciudad Autonoma de Buenos Aires
Centro Medico Dra De Salvo ( Site 1904), Ciudad Autonoma de Buenos Aires
Hospital Universitario Austral ( Site 1901), Pilar
Instituto De Enfermedades Respiratorias E Investigacion Medica ( Site 1910), Villa Vatteone
Instituto Médico DAMIC ( Site 1909), Córdoba
Instituto Medico Rio Cuarto ( Site 1907), Río Cuarto
Instituto Cardiovascular de Rosario ( Site 1906), Rosario
Sanatorio Parque ( Site 1905), Rosario
Sanatorio Allende ( Site 1908), Córdoba
Hospital Provincial Dr. Jose M. Cullen ( Site 1902), Santa Fe
Hospital Madre Teresa ( Site 1804), Belo Horizonte
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 1805), Porto Alegre
Hospital Sao Paulo ( Site 1806), São Paulo
Instituto do Coracao - HCFMUSP ( Site 1803), São Paulo
University of Alberta Hospital ( Site 2101), Edmonton
St Boniface General Hospital ( Site 2106), Winnepeg
McMaster University - HSC ( Site 2105), Hamilton
Sir Mortimer B Davis Jewish General Hospital ( Site 2103), Montreal
Institut Klinicke a Experimentalni Mediciny ( Site 2202), Prague
Vseobecna fakultni nemocnice v Praze ( Site 2201), Prague
Hopital Louis Pasteur ( Site 1311), Nice
Universitaetsklinikum Carl Gustav Carus ( Site 1501), Dresden
Universitatsklinikum Leipzig ( Site 1508), Leipzig
Universitaetsklinik und Poliklinik Halle/Saale ( Site 1502), Halle
Evangelismos General Hospital of Athens ( Site 3605), Athens
Onassis Cardiac Surgery Center ( Site 3602), Athens
Attikon University General Hospital of Athens ( Site 3604), Haidari
AHEPA University General Hospital of Thessaloniki ( Site 3601), Thessaloniki
Radboud University Nijmegen Medical Centre ( Site 2605), Nijmegen
Maastricht University Medical Center ( Site 2603), Maastricht
VU Medisch Centrum ( Site 2601), Amsterdam
Erasmus MC ( Site 2604), Rotterdam
Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 2801), Krakow
Instytut Gruzlicy i Chorob Pluc w Warszawie ( Site 2802), Warsaw
Hospital Garcia de Orta ( Site 3501), Almada
Centro Hospitalar E Universitário De Coimbra ( Site 3502), Coimbra
Hospital Pulido Valente ( Site 3503), Lisbon
Samsung Medical Center ( Site 3106), Seuol
Seoul National University Hospital ( Site 3102), Seoul
Severance Hospital Yonsei University Health System - PPDS ( Site 3101), Seoul
The Catholic University of Korea St. Mary s Hospital ( Site 3104), Seoul
Hospital Universitario de Son Espases ( Site 1611), Palma de Mallorca
Hospital Universitari Vall de Hebron ( Site 1605), Barcelona
Hjart-lungmedicin och klinisk fysiologi ( Site 3204), Uppsala
Papworth Hospital NHS Foundation Trust ( Site 1208), Cambrigge
Sheffield Teaching Hospital NHS Foundation Trust ( Site 1207), Sheffield
Golden Jubilee National Hospital ( Site 1204), Glasgow
Royal Free London NHS Foundation Trust ( Site 1202), London
Royal Brompton Hospital ( Site 1206), London
Imperial College Healthcare NHS Trust ( Site 1203), London
Freeman Hospital ( Site 1205), Newcastle upon Tyne
Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
INDUSTRY