SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa

NACompletedINTERVENTIONAL
Enrollment

2,233

Participants

Timeline

Start Date

April 15, 2021

Primary Completion Date

October 16, 2023

Study Completion Date

October 16, 2023

Conditions
HIVHypertensionAlcohol DrinkingMaternal Child HealthCost Effectiveness
Interventions
OTHER

Mobility Dynamic Treatment Intervention

"1\) Access to a mobility coordinator who will assist with transfers, rescheduling, and out-of-facility refills; 2) Provision of a travel pack with alternative ART packaging options (e.g. ziplock bags, envelopes, pill boxes), a packing list and mobility coordinator phone contact for unplanned travel; 3) Screening at every clinic visit for planned mobility; 4) Mobile number and mobile minutes for unexpected travel; 5) Provision of longer refills (up to 6-months) for planned travel"

OTHER

Health Living Intervention for Heavy Alcohol Users

1\) Two in-person alcohol counseling sessions with support from a clinical psychologist; 2) Monthly booster phone calls

OTHER

Hypertension Linkage

1\) Travel voucher (financial incentive) conditional on linkage to hypertensive care; 2) Phone call reminders for missed visits

OTHER

PrEP/PEP at Outpatient Clinics

Intervention delivered at Outpatient Clinics: Counseling and education on and choice between prevention modalities (e.g. PrEP, PEP, condoms), choice of service location, provision of a clinical officer's or nurse's mobile telephone number for immediate PEP starts any day of the week, routine assessment of barriers to initiation or adherence to PrEP/PEP, including the offer of personalized potential solutions such as choice of in-clinic or offsite service delivery, psychologic supports for traumatic experiences, and offer of concurrent, additional health or prevention related services

OTHER

PrEP/PEP at Antenatal Clinics

Intervention delivered at Antenatal Clinics: Counseling and education on and choice between prevention modalities (e.g. PrEP, PEP, condoms), choice of service location, provision of a clinical officer's or nurse's mobile telephone number for immediate PEP starts any day of the week, routine assessment of barriers to initiation or adherence to PrEP/PEP, including the offer of personalized potential solutions such as choice of in-clinic or offsite service delivery, psychologic supports for traumatic experiences, and offer of concurrent, additional health or prevention related services

OTHER

PrEP/PEP at Community Households

Intervention delivered in community by village health team: Counseling and education on and choice between prevention modalities (e.g. PrEP, PEP, condoms), choice of service location, provision of a clinical officer's or nurse's mobile telephone number for immediate PEP starts any day of the week, routine assessment of barriers to initiation or adherence to PrEP/PEP, including the offer of personalized potential solutions such as choice of in-clinic or offsite service delivery, psychologic supports for traumatic experiences, and offer of concurrent, additional health or prevention related services

OTHER

Standard of Care

Local country standard of care protocols

OTHER

Hypertension Community

Hypertension care delivered at home with clinician telehealth, facilitated by lay health worker to measure blood pressure and deliver medications

Trial Locations (2)

Unknown

GPRT / SEARCH Office, Kisumu

IDRC Southwest Uganda, Mbarara

Sponsors
All Listed Sponsors
collaborator

Infectious Diseases Research Collaboration, Uganda

OTHER

collaborator

Makerere University

OTHER

collaborator

Kenya Medical Research Institute

OTHER

collaborator

University of California, Berkeley

OTHER

collaborator

University College, London

OTHER

collaborator

University of Pennsylvania

OTHER

collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

collaborator

National Institute of Mental Health (NIMH)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

University of California, San Francisco

OTHER