Gut Microbiota, PGx and INSTIs Response

CompletedOBSERVATIONAL
Enrollment

180

Participants

Timeline

Start Date

March 10, 2021

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2023

Conditions
HIV Infections
Interventions
DRUG

Dolutegravir

Dolutegravir treated patients will be included and samples (blood for pharmacokinetic, pharmacogenetic et metabolite profiling, stools for microbiota profiling) drawn at follow-up.

DRUG

Bictegravir

Bictegravir treated patients will be included and samples (blood for pharmacokinetic, pharmacogenetic and metabolite profiling, stools for microbiota profiling) drawn at follow-up.

DRUG

Dolutegravir

Patient having discontinued dolutegravir will be included and samples (blood for pharmacogenetic and metabolite profiling, stools for microbiota profiling) drawn at follow-up.

DRUG

Dolutegravir

Patients starting dolutegravir will be included and sampled both before (blood for pharmacogenetic and metabolite profiling, stools for microbiota profiling) and after (blood for pharmacokinetic and metabolite profiling, stools for microbiota profiling) the start of dolutegravir

DRUG

Bictegravir

Patients starting bictegravir will be included and sampled both before (blood for pharmacogenetic and metabolite profiling, stools for microbiota profiling) and after (blood for pharmacokinetic and metabolite profiling, stools for microbiota profiling) the start of bictegravir

Trial Locations (1)

Unknown

Cliniques universitaires Saint-Luc, Brussels

All Listed Sponsors
lead

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

OTHER

NCT04805944 - Gut Microbiota, PGx and INSTIs Response | Biotech Hunter | Biotech Hunter