Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

PHASE3RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

June 10, 2021

Primary Completion Date

July 1, 2028

Study Completion Date

July 1, 2030

Conditions
Metastatic Lung Small Cell CarcinomaMetastatic Malignant Neoplasm in the BrainRecurrent Lung Small Cell CarcinomaStage IV Lung Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Memantine Hydrochloride

Given PO

OTHER

Neurocognitive Assessment

Ancillary studies

RADIATION

Stereotactic Radiosurgery

Undergo SRS

OTHER

Survey Administration

Ancillary studies

RADIATION

Whole-Brain Radiotherapy

Undergo HA-WBRT

Trial Locations (223)

10032

ACTIVE_NOT_RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10461

ACTIVE_NOT_RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

ACTIVE_NOT_RECRUITING

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

ACTIVE_NOT_RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

10549

ACTIVE_NOT_RECRUITING

Northern Westchester Hospital, Mount Kisco

11042

ACTIVE_NOT_RECRUITING

Northwell Health/Center for Advanced Medicine, Lake Success

13126

RECRUITING

Upstate Cancer Center Radiation Oncology at Oswego, Oswego

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

RECRUITING

Upstate Cancer Center at Hill Radiation Oncology, Syracuse

13478

SUSPENDED

Upstate Cancer Center at Verona, Verona

14424

ACTIVE_NOT_RECRUITING

Sands Cancer Center, Canandaigua

14580

ACTIVE_NOT_RECRUITING

Wilmot Cancer Institute at Webster, Webster

14606

ACTIVE_NOT_RECRUITING

Wilmot Cancer Institute Radiation Oncology at Greece, Rochester

14642

ACTIVE_NOT_RECRUITING

University of Rochester, Rochester

15146

RECRUITING

UPMC Cancer Center - Monroeville, Monroeville

15212

ACTIVE_NOT_RECRUITING

Allegheny General Hospital, Pittsburgh

15213

RECRUITING

UPMC-Magee Womens Hospital, Pittsburgh

RECRUITING

UPMC-Presbyterian Hospital, Pittsburgh

15215

RECRUITING

UPMC-Saint Margaret, Pittsburgh

15232

RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15243

RECRUITING

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16544

ACTIVE_NOT_RECRUITING

Saint Vincent Hospital, Erie

16601

RECRUITING

UPMC Altoona, Altoona

17015

RECRUITING

Carlisle Regional Cancer Center, Carlisle

17042

RECRUITING

Sechler Family Cancer Center, Lebanon

17109

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17201

RECRUITING

Chambersburg Hospital, Chambersburg

17325

RECRUITING

Adams Cancer Center, Gettysburg

17403

RECRUITING

WellSpan Health-York Cancer Center, York

RECRUITING

WellSpan Health-York Hospital, York

17408

RECRUITING

UPMC Memorial, York

17522

RECRUITING

Ephrata Cancer Center, Ephrata

17754

RECRUITING

Divine Providence Hospital, Williamsport

17822

RECRUITING

Geisinger Medical Center, Danville

17837

RECRUITING

Geisinger Medical Oncology-Lewisburg, Lewisburg

18015

ACTIVE_NOT_RECRUITING

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

18045

ACTIVE_NOT_RECRUITING

Saint Luke's Hospital-Anderson Campus, Easton

18104

ACTIVE_NOT_RECRUITING

Saint Luke's Cancer Center - Allentown, Allentown

18360

ACTIVE_NOT_RECRUITING

Saint Luke's Hospital - Monroe Campus, Stroudsburg

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18951

ACTIVE_NOT_RECRUITING

Saint Luke's Hospital - Upper Bucks Campus, Quakertown

SUSPENDED

Saint Luke's Hospital-Quakertown Campus, Quakertown

19107

SUSPENDED

Thomas Jefferson University Hospital, Philadelphia

19114

SUSPENDED

Jefferson Torresdale Hospital, Philadelphia

19317

RECRUITING

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

SUSPENDED

Delaware Clinical and Laboratory Physicians PA, Newark

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19718

RECRUITING

Christiana Care Health System-Christiana Hospital, Newark

19801

RECRUITING

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

RECRUITING

Beebe Medical Center, Lewes

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

21014

RECRUITING

UM Upper Chesapeake Medical Center, Bel Air

21044

RECRUITING

Central Maryland Radiation Oncology in Howard County, Columbia

21061

RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

21237

SUSPENDED

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

21401

ACTIVE_NOT_RECRUITING

Luminis Health Anne Arundel Medical Center, Annapolis

21601

RECRUITING

University of Maryland Shore Medical Center at Easton, Easton

21801

ACTIVE_NOT_RECRUITING

TidalHealth Peninsula Regional, Salisbury

21811

ACTIVE_NOT_RECRUITING

TidalHealth Richard A Henson Cancer Institute, Ocean Pines

23298

ACTIVE_NOT_RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

29303

ACTIVE_NOT_RECRUITING

Spartanburg Medical Center, Spartanburg

29341

ACTIVE_NOT_RECRUITING

Gibbs Cancer Center-Gaffney, Gaffney

29379

ACTIVE_NOT_RECRUITING

SMC Center for Hematology Oncology Union, Union

29506

RECRUITING

McLeod Regional Medical Center, Florence

29646

RECRUITING

Self Regional Healthcare, Greenwood

29651

ACTIVE_NOT_RECRUITING

Gibbs Cancer Center-Pelham, Greer

30041

RECRUITING

Northside Hospital-Forsyth, Cumming

30115

RECRUITING

Northside Hospital-Cherokee, Canton

30308

ACTIVE_NOT_RECRUITING

Emory University Hospital Midtown, Atlanta

30322

ACTIVE_NOT_RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

ACTIVE_NOT_RECRUITING

Emory Saint Joseph's Hospital, Atlanta

RECRUITING

Northside Hospital, Atlanta

31404

RECRUITING

Memorial Health University Medical Center, Savannah

32610

ACTIVE_NOT_RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

33136

ACTIVE_NOT_RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33442

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33544

RECRUITING

Moffitt Cancer Center at Wesley Chapel, Wesley Chapel

33607

RECRUITING

Moffitt Cancer Center-International Plaza, Tampa

33612

RECRUITING

Moffitt Cancer Center - McKinley Campus, Tampa

RECRUITING

Moffitt Cancer Center, Tampa

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

40503

ACTIVE_NOT_RECRUITING

Baptist Health Lexington, Lexington

43015

RECRUITING

Delaware Health Center-Grady Cancer Center, Delaware

RECRUITING

Grady Memorial Hospital, Delaware

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43214

RECRUITING

Riverside Methodist Hospital, Columbus

43215

RECRUITING

Grant Medical Center, Columbus

43551

RECRUITING

Mercy Health - Perrysburg Hospital, Perrysburg

43623

SUSPENDED

Mercy Health - Saint Anne Hospital, Toledo

44060

RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

RECRUITING

Case Western Reserve University, Cleveland

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46032

RECRUITING

IU Health North Hospital, Carmel

46123

RECRUITING

IU Health West Hospital, Avon

46202

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

RECRUITING

IU Health Methodist Hospital, Indianapolis

46526

RECRUITING

Goshen Center for Cancer Care, Goshen

48043

RECRUITING

McLaren Cancer Institute-Macomb, Mount Clemens

48060

RECRUITING

McLaren-Port Huron, Port Huron

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48201

RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48334

RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

48446

RECRUITING

McLaren Cancer Institute-Lapeer Region, Lapeer

48453

SUSPENDED

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette

48532

RECRUITING

McLaren Cancer Institute-Flint, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48604

SUSPENDED

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

SUSPENDED

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48706

RECRUITING

McLaren Cancer Institute-Bay City, Bay City

48723

SUSPENDED

Caro Cancer Center, Caro

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

48910

RECRUITING

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

49770

RECRUITING

McLaren Cancer Institute-Northern Michigan, Petoskey

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

53051

RECRUITING

Froedtert Menomonee Falls Hospital, Menomonee Falls

53095

RECRUITING

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53154

RECRUITING

Drexel Town Square Health Center, Oak Creek

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54017

RECRUITING

Cancer Center of Western Wisconsin, New Richmond

54401

RECRUITING

Aspirus Regional Cancer Center, Wausau

54409

RECRUITING

Langlade Hospital and Cancer Center, Antigo

54481

RECRUITING

Aspirus Cancer Care - Stevens Point, Stevens Point

54501

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54601

ACTIVE_NOT_RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

55082

RECRUITING

Lakeview Hospital, Stillwater

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55109

RECRUITING

Minnesota Oncology Hematology PA-Maplewood, Maplewood

55125

RECRUITING

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

RECRUITING

Minnesota Oncology - Burnsville, Burnsville

55362

RECRUITING

Monticello Cancer Center, Monticello

55369

RECRUITING

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55432

ACTIVE_NOT_RECRUITING

Unity Hospital, Fridley

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

56303

RECRUITING

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

57105

ACTIVE_NOT_RECRUITING

Avera Cancer Institute, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59101

SUSPENDED

Billings Clinic Cancer Center, Billings

59405

SUSPENDED

Benefis Sletten Cancer Institute, Great Falls

59901

SUSPENDED

Logan Health Medical Center, Kalispell

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60451

SUSPENDED

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60504

RECRUITING

Rush-Copley Medical Center, Aurora

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60612

ACTIVE_NOT_RECRUITING

Rush University Medical Center, Chicago

60637

SUSPENDED

University of Chicago Comprehensive Cancer Center, Chicago

61637

RECRUITING

OSF Saint Francis Medical Center, Peoria

61801

RECRUITING

Carle Cancer Center, Urbana

RECRUITING

The Carle Foundation Hospital, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

64804

RECRUITING

Freeman Health System, Joplin

65804

RECRUITING

Mercy Hospital Springfield, Springfield

70809

RECRUITING

Mary Bird Perkins Cancer Center, Baton Rouge

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

M D Anderson Cancer Center, Houston

77079

RECRUITING

MD Anderson West Houston, Houston

77384

RECRUITING

MD Anderson in The Woodlands, Conroe

77478

RECRUITING

MD Anderson in Sugar Land, Sugar Land

77573

RECRUITING

MD Anderson League City, League City

80045

ACTIVE_NOT_RECRUITING

UCHealth University of Colorado Hospital, Aurora

80909

ACTIVE_NOT_RECRUITING

UCHealth Memorial Hospital Central, Colorado Springs

80920

ACTIVE_NOT_RECRUITING

Memorial Hospital North, Colorado Springs

85054

ACTIVE_NOT_RECRUITING

Mayo Clinic Hospital in Arizona, Phoenix

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

90706

RECRUITING

Kaiser Permanente-Bellflower, Bellflower

91761

RECRUITING

Kaiser Permanente-Ontario, Ontario

92806

RECRUITING

Kaiser Permanente-Anaheim, Anaheim

06830

TERMINATED

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

TERMINATED

Smilow Cancer Hospital Care Center - Guilford, Guilford

06510

TERMINATED

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

TERMINATED

Yale University, New Haven

06611

TERMINATED

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06385

TERMINATED

Smilow Cancer Hospital Care Center - Waterford, Waterford

02118

RECRUITING

Boston Medical Center, Boston

08103

RECRUITING

Cooper Hospital University Medical Center, Camden

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

M5G 2M9

SUSPENDED

University Health Network-Princess Margaret Hospital, Toronto

G1R 2J6

RECRUITING

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

S4T 7T1

RECRUITING

Allan Blair Cancer Centre, Regina

S7N 4H4

RECRUITING

Saskatoon Cancer Centre, Saskatoon

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER