Study of Ibrutinib + CD20 Antibody and Venetoclax in Patients With Untreated Mantle Cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

194

Participants

Timeline

Start Date

January 24, 2022

Primary Completion Date

March 31, 2026

Study Completion Date

September 30, 2031

Conditions
Mantle Cell Lymphoma
Interventions
DRUG

Ibrutinib 560 mg

560mg/d continuously from C1D2 to end C24

DRUG

Venetoclax 10 MG Oral Tablet [Venclexta]

20mg/d from C2D1 to C2D7

DRUG

Venetoclax 50 MG Oral Tablet [Venclexta]

50mg/d from C2D8 to C2D14

DRUG

Venetoclax 100 MG Oral Tablet [Venclexta]

100mg/d from C2D15 to C2D21 200mg/d from C2D22 to C2D28 400mg/d from C3D1 to end C24

Trial Locations (45)

1070

RECRUITING

Universite Libre de Bruxelles - Hopital ERASME, Brussels

4000

RECRUITING

CHU de Liege, Liège

5530

RECRUITING

Universite Catholique de Louvain Mont Godinne, Yvoir

7100

RECRUITING

Hopital Jolimont, Haine-Saint-Paul

8000

RECRUITING

A.Z. Sint Jan AV, Bruges

13273

RECRUITING

Institut Paoli Calmettes, Marseille

14033

RECRUITING

Institut d'Hématologie de Basse Normandie, Caen

21000

RECRUITING

CHU de DIJON, Dijon

25030

RECRUITING

CHU Jean Minioz, Besançon

29107

RECRUITING

CH de Cornouaille, Quimper

29609

RECRUITING

Chu Morvan, Brest

31100

RECRUITING

IUCT Oncopole, Toulouse

33604

RECRUITING

Chu de Bordeaux - Hopital Haut-Leveque - Centre Francois Magendie, Pessac

34295

RECRUITING

CHU de Montpellier, Montpellier

35033

RECRUITING

CHU Pontchaillou, Rennes

37044

RECRUITING

CHU Bretonneau, Tours

38700

RECRUITING

CHU de Grenoble, La Tronche

42270

RECRUITING

Institut de Cancérologie de la Loire Lucien Neuwirth, Saint-Priest-en-Jarez

44093

RECRUITING

CHU de Nantes, Nantes

49033

RECRUITING

CHU d'Angers, Angers

51092

RECRUITING

CHU de REIMS, Reims

54511

RECRUITING

CHU Nancy Brabois, Vandœuvre-lès-Nancy

56017

RECRUITING

CH de Bretagne Atlantique - Hopital CHUBERT, Vannes

59037

RECRUITING

CHRU de Lille, Lille

63003

RECRUITING

Chu Estaing, Clermont-Ferrand

64109

RECRUITING

CH de la Côte Basque, Bayonne

67033

RECRUITING

Institut de Cancérologie Strasbourg Europe, Strasbourg

69373

RECRUITING

Centre Léon Bérard, Lyon

69495

RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

74374

RECRUITING

Ch Annecy Gennevois, Pringy

75475

RECRUITING

Hopital St-Louis, Paris

75743

RECRUITING

Hopital NECKER, Paris

76038

RECRUITING

Centre Henri BECQUEREL, Rouen

84000

RECRUITING

CH d'Avignon - Hopital Henri Duffaut, Avignon

85925

RECRUITING

CHD de Vendée, La Roche-sur-Yon

86021

RECRUITING

Hopital de la Milétrie, Poitiers

87042

RECRUITING

Hopital DUPUYTREN, Limoges

92210

RECRUITING

Hopital René Huguenin, Saint-Cloud

94010

RECRUITING

CH Henri Mondor, Créteil

94805

RECRUITING

Institut Gustave ROUSSY, Villejuif

M20 4BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

NR4 7UY

RECRUITING

Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich

OX3 7LE

RECRUITING

Oxford University Hospitals NHS Foundation Trust, Oxford

PL6 8DH

RECRUITING

University Hospitals Plymouth NHS Trust, Plymouth

TR1 3LJ

RECRUITING

Royal Cornwall Hospital Trust, Truro

All Listed Sponsors
collaborator

Institute of Cancer Research, United Kingdom

OTHER

lead

The Lymphoma Academic Research Organisation

OTHER