Aging and the Mitochondrial Response to Exercise Training, Measured by Noninvasive 31P Magnetic Resonance Spectroscopy

NACompletedINTERVENTIONAL
Enrollment

352

Participants

Timeline

Start Date

August 2, 2021

Primary Completion Date

May 12, 2025

Study Completion Date

May 12, 2025

Conditions
Physical Activity
Interventions
OTHER

Isometric Contraction Exercise - Young Adults (Age group 18-39)

Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

OTHER

Isometric Contraction Exercise - Middle Age Adults (Age group 40-59)

Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

OTHER

Isometric Contraction Exercise - Old Adults (Age group >60)

Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

Trial Locations (1)

70808

Pennington Biomedical Research Center, Baton Rouge

All Listed Sponsors
collaborator

University of Colorado, Denver

OTHER

collaborator

University of Pittsburgh

OTHER

collaborator

The University of Texas Health Science Center at San Antonio

OTHER

collaborator

AdventHealth Translational Research Institute

OTHER

collaborator

Stanford University

OTHER

collaborator

Wake Forest University Health Sciences

OTHER

lead

Pennington Biomedical Research Center

OTHER

NCT04799171 - Aging and the Mitochondrial Response to Exercise Training, Measured by Noninvasive 31P Magnetic Resonance Spectroscopy | Biotech Hunter | Biotech Hunter