Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome

PHASE3TerminatedINTERVENTIONAL
Enrollment

246

Participants

Timeline

Start Date

February 8, 2021

Primary Completion Date

November 13, 2024

Study Completion Date

November 13, 2024

Conditions
Myelodysplastic Syndromes
Interventions
DRUG

Tamibarotene

Administered as specified in the treatment arm

DRUG

Placebo

Administered as specified in the treatment arm

DRUG

Azacitidine

Administered as specified in the treatment arm

Trial Locations (128)

1083

Semmelweis Egyetem, Budapest

4400

Josa Andras Teaching Hospital, Nyíregyháza

5020

Salzburg Cancer Research Institute (SCRI), Salzburg

5530

CHU-UCL Namur, Yvoir

7100

Hospital De Jolimont, La Louvière

8036

Medical University of Graz, Graz

8800

AZ Delta, Roeselare

11042

Northwell Health, Lake Success

16132

Ospedale Policlinico San Martino, Genova

20817

American Oncology Partners of Maryland, PA, Bethesda

21287

Johns Hopkins University, Baltimore

27103

Novant Health Cancer Institute - Forsyth, Winston-Salem

27157

Wake Forest Baptist Health, Winston-Salem

28033

MD Anderson Cancer Center, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28046

H. Universitario La Paz, Madrid

28100

A.O.U. Maggiore della Carità, Novara

28204

Novant Health Inc, Charlotte

29200

CHRU de BREST - Hôpital Morvan, Brest

31008

Clinica Universidad Navarra, Pamplona

31048

Bnai Zion Medical center, Haifa

33011

Hospital Universitario Central de Asturia, Oviedo

33604

CHU Bordeaux, Pessac

33612

Moffitt Cancer Center, Tampa

33709

Comprehensive Hematology and Oncology, St. Petersburg

37007

Hospital Universitario de Salamanca, Salamanca

37203

TriStar - Sarah Cannon BMT, Nashville

39008

Hospital Universitario Marqués de Valdecilla, Santander

40138

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna

41013

Hospital Universitario Virgen Del Rocio, Seville

43210

The Ohio State University Comprehensive Cancer Center, Columbus

44093

CHU Nantes - Hotel Dieu, Nantes

44124

Azienda Ospedaliero-Universitaria di Ferrara, Ferrara

46026

Hospital Universitario y Politécnico La Fe, Valencia

47014

"Romagnolo Institute to Study Tumors Dino Amadori / Meldona", Meldola

49933

CHU d'Angers, Angers

52242

University of Iowa, Iowa City

60077

Orchard Healthcare Research Inc., Skokie

60612

University of Illinois Cancer Center, Chicago

61122

Ospedali Marche Nord Centro Ematologia e Trapianti, Pesaro

64109

Centre Hospitalier de la Côte Basque Hématologie Clinique, Bayonne

67033

ICANS Strasbourg, Strasbourg

69373

Centre Léon Bérard, Lyon

69495

CHU Lyon Sud, Pierre-Bénite

70112

Tulane Cancer Center, New Orleans

75475

Hôpital Saint Louis, Paris

78150

Hopital Mignot, Le Chesnay

80054

CHU Amiens-Picardie, Amiens

84112

University of Utah Huntsman Cancer Institute, Salt Lake City

85719

University of Arizona, Tucson

86021

CHU Poiters, Poitiers

87000

CHU de Limoges, Limoges

90033

University of Southern California, Los Angeles

90095

University of California, Los Angelas, Los Angeles

93000

Hôpital Avicenne, Bobigny

94805

Institut Gustave Roussy, Villejuif

97239

Oregon Health and Science University, Portland

98104

Swedish Cancer Institute, Seattle

7661041

Kaplan Medical Center, Rehovot

9103102

Shaare Zedek Medical Center, Jerusalem

06510

Yale Cancer Center, New Haven

02140

Morristown Medical Center- Atlantic Hematology Oncology, Morristown

Unknown

Klinik Hietzing, Vienna

ZNA Middelheim, Antwerp

Institut Jules Bordet, Brussels

Ghent University Hospital, Ghent

CHU de Liège, Liège

CancerCare Manitoba, Winnipeg

Princess Margaret Cancer Centre - University Health Network, Toronto

Tom Baker Cancer Centre, Calgary

Fakultni nemocnice Olomouc (University Hospital Olomouc), Olomouc

University Hospital Ostrava, Ostrava

General University Hospital Prague, Prague

CHU Clermont Ferrand / CHU Estaing, Clermont-Ferrand

CHU Grenoble Alpes Hôpital Nord Michallon, La Tronche

CHU la Conception, Marseille

CHU Saint Etienne, Saint-Priest-en-Jarez

Universitätsklinikum Augsburg, Augsburg

Helios Klinikum Berlin Buch GmbH, Berlin

Universitätsklinikum Freiburg, Freiburg im Breisgau

Universitätsmedizin Göttingen, Göttingen

Universitätsklinikum Halle (Saale), Halle

Universitätsklinikum Marburg, Marburg

Universitätsklinikum Münster, Münster

Markhot Ferenc Oktatókórház és Rendelőintézet, Belgyógyászati- és Infektológiai Centrum, Eger

Petz Aladar County Teaching Hospital, Győr

Barzilai Medical Center of Ashkelon, Ashkelon

Sheba Medical Center, Ramat Gan

Tel Aviv Sourasky Medical Center, Tel Aviv

ASST Spedali Civili di Brescia, Brescia

AOU Careggi, Florence

Ospedale S.Maria delle Croci, Ravenna

Ospedale S. Eugenio - ASL Roma 2, Roma

AOUI di Verona, Verona

Instytut Hematologii i Transfuzjologii, Klinika Hematologii, Warsaw

University Clinic Warsaw, Warsaw

Alfred Sokołowski Hospital Wałbrzych, Wałbrzych

Institut Catala d'Oncologia - Hospital Duran i Reynals Location, Badalona

Hospital del Mar Secretaria d'Hematologia Clínica, Barcelona

Hospital San Pedro de Alcántara, Cáceres

Hospital Universitario de La Princesa, Madrid

Hospital General Universitario J.M. Morales Meseguer, Murcia

Hospital Universitario Donostia, San Sebastián

Hospital Clinico Universitario de Valencia, Valencia

Castle Hill Hospital, Cottingham, Cottingham

Ninewells Hospital, Dundee

Western General Hospital in NHS Lothian Edinburgh Scotland, Edinburgh

Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

King's College Hospital NHS Foundation Trust, London

The Royal Marsden Foundation Trust, London

University Hospital Southampton NHS Foundation Trust, Southampton

Sandwell and West Birmingham Hospital NHS Trust, West Bromwich

ON L8V 1C3

Juravinski Cancer Centre, Hamilton

N6A 5W9

London Health Sciences Center, London

H4A 3J1

McGill University Health Centre (MUHC), Montreal

ON

London Health Sciences Centre, London

06200

CHU de Nice - Hopital L'Archet, Nice

H-4012

Debrecen University Medical and Health Science Centre, Debrecen

00133

Fondazione Policlinico Tor Vergata, Rome

80-952

University Clinic Gdansk, Gdansk

81-519

Pomeranian Hospital Gdynia, Gdynia

59-220

Wojewodzki Szpital Specjalistyczny w Legnicy, Legnica

08003

Hospital del Mar, Barcelona

08025

H. Santa Creu i Sant Pau, Barcelona

08035

Fundación Privada Instituto de Investigación Oncológica Vall d'Hebron, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

09006

Hospital Universitario de Burgos, Burgos

07198

Hospital Son Llatzer, Palma de Mallorca

Sponsors
All Listed Sponsors
lead

Syros Pharmaceuticals

INDUSTRY