Value of the Laparoscopic Approach in the Surgical Management of Resectable Hepatocellular Carcinoma

NAActive, not recruitingINTERVENTIONAL
Enrollment

252

Participants

Timeline

Start Date

May 21, 2021

Primary Completion Date

April 30, 2025

Study Completion Date

May 7, 2027

Conditions
Hepatocellular Carcinoma
Interventions
PROCEDURE

Laparoscopy

"* Installations of the patient: the position of the patient will depend on both extent of resection and location of the lesion.~* Absence of laparotomy with the exception of the extraction of the resected specimen and absence of costal retractors.~* Use of laparoscopic specific devices:~ * Use of multiple (3-7) ports depending on the operator's preference and technical difficulty (mainly 5-6 ports for major liver resection).~ * Use of a laparoscopic camera system with 0° or 30°~ * Use of a dedicated laparoscopic ultrasound probe.~ * Use of specific laparoscopic devices for coagulation, parenchymal transection and sealing.~* Placement of the resected specimen in a plastic bag and extraction without fragmentation, depending on the surgeon's preferenceand the diameter of the resected specimen"

PROCEDURE

Laparotomy

"* Installation of the patient: patients will be placed in supine position, the surgeon operating on the right side of the patient and the assistant standing on the left side.~* Incision: the type of incision will depend on both the nature of the resection and the operator's preference. Various incisions such as bi subcostal incision, J-shaped incision, right subcostal incision and midline incision can be used.~* Use of open surgical instruments and devices for coagulation and parenchymal transection. These may include the crush-clamp technique or ultrasonic dissection for parenchymal transection, bipolar coagulation, clips, sutures or open vascular stapler for hemostasis and biliostasis.~* Methylene blue injection through the cystic drain to rule out biliary leakage will be performed depending on the surgeon's preference."

Trial Locations (17)

13005

Chirurgie Digestive - Hôpital La Timone, Marseille

25000

Chirurgie viscérale et digestive - CHU Besançon, Besançon

31059

Chirurgie hépato-bilio-pancréatique et Transplantation - Hôpital Rangueil, Toulouse

34090

Chirurgie Digestive - CHU Montpellier, Montpellier

37000

Chirurgie digestive Oncologique Endocrinienne et Transplantation hépatique - CHU Tours, Tours

38700

Chirurgie Digestive et de l'Urgence - CHU Grenoble, Grenoble

59021

Chirurgie Digestive et Transplantations - Hôpital Huriez, Lille

69317

Chirurgie Générale, Digestive et de la Transplantation hépatique - Hôpital de la Croix Rousse, Lyon

75014

Chirurgie digestive - Institut Mutualiste Montsouris, Paris

Cochin hospital, Paris

75651

Chirurgie hépato-biliaire et greffe de foie - La Pitié, Paris

76000

Chirurgie viscérale et digestive - CHU Rouen, Rouen

80054

Chirurgie Digestive - CHU Amiens, Amiens

92110

Chirurgie Hépatologie - Hôpital Beaujon, Clichy

94010

Chirurgie Digestive et Hépatobiliaire - Hôpital Henri-Mondor, Créteil

94800

Centre hépatobiliaire de transplantation hépatique - Hopital Paul Brousse, Villejuif

Unknown

CHU Rennes - Pontchaillou, Rennes

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER