Evaluation of the Effect of IHHT on Vascular Stiffness and Elasticity of the Liver Tissue in Patients With MS.

NACompletedINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

April 10, 2019

Primary Completion Date

November 30, 2020

Study Completion Date

December 3, 2020

Conditions
Vascular StiffnessLiver FibrosesMetabolic SyndromeTrimethylamine N-oxydeToll-like Receptors
Interventions
PROCEDURE

Interval hypoxic-hyperoxic training (IHHT) using respiratory therapy unit ReOxy.

Every patient from control group undergo 15 procedures of IHHT, 5 procedures per week for 3 weeks, 1 procedure lasts 40 minutes. IHHT is a protocol which employs passive (the patient is at rest), short (several minutes) mild normobaric hypoxic exposures alternated with similar duration intervals of breathing hyperoxia, and repeated for 40 minutes. During the initial pretreatment test, the patient inhales air with low oxygen content at atmospheric pressure in a continuous mode through a mask. In the interval therapeutic mode that follows, periods of hypoxia (10-14% O2) are interrupted by periods of reoxygenation by hyperoxia (up to 35% O2). Automatic switching of gas flows (SRT technology). Built-in intelligent software automatically identifies and suggests key treatment parameters for the individual treatment program, by adjusting the starting parameters based upon the results of the pretreatment hypoxic test.

PROCEDURE

Simulating Interval hypoxic-hyperoxic training (IHHT) using respiratory therapy unit ReOxy.

Every patient from group control undergo simulating procedures of interval hypoxic-hyperoxic training, 15 procedures, 5 procedures per week for 3 weeks. 1 procedure lasts 40 minutes, in normoxia. Before the start of the course, each patient undergoes a test procedure for 10 minute (in normoxia) for simulate procedures IHHT.

Trial Locations (1)

119435

University Clinical Hospital №1 Sechenov University, Moscow

All Listed Sponsors
lead

I.M. Sechenov First Moscow State Medical University

OTHER

NCT04791397 - Evaluation of the Effect of IHHT on Vascular Stiffness and Elasticity of the Liver Tissue in Patients With MS. | Biotech Hunter | Biotech Hunter