A Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus

PHASE2CompletedINTERVENTIONAL
Enrollment

206

Participants

Timeline

Start Date

June 25, 2021

Primary Completion Date

January 30, 2025

Study Completion Date

January 30, 2025

Conditions
Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Interventions
DRUG

Lomvastomig

2100 milligrams (mg) administered by intravenous (IV) infusion once every 2 weeks on Day 1 of each 14-day cycle.

DRUG

Tobemstomig

2100 mg administered by IV infusion once every 2 weeks on Day 1 of each 14-day cycle.

DRUG

Nivolumab

240 mg administered by IV infusion once every 2 weeks on Day 1 of each 14-day cycle.

Trial Locations (53)

500

Changhua Christian Hospital, Chang-hua

2100

Rigshospitalet, København Ø

5000

Odense Universitetshospital, Onkologisk Afdeling R, Odense C

5004

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet, Szolnok

10000

Dicle Uni Medical Faculty, Diyarbakır

10048

National Taiwan University Hospital, Zhongzheng Dist.

10400

Ramathibodi Hospital, Bangkok

10700

Siriraj Hospital, Bangkok

13385

Hopital Timone Adultes, Marseille

25240

Ataturk University Medical Faculty Yakutiye Research Hospital Medical Oncology Department, Erzurum

30100

International Cancer Institute (ICI), Eldoret

31008

Complejo Hospitalario de Navarra, Pamplona

33076

Institut Bergonie, Bordeaux

33100

Azienda Sanitaria Universitaria Integrata di Udine - PO Universitario Santa Maria della, Udine

34298

Institut régional du Cancer Montpellier, Montpellier

35128

IRCCS Istituto Oncologico Veneto (IOV), Padua

40005

Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary, Sumy

44280

Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department, Malatya

44805

ICO Rene Gauducheau, Saint-Herblain

46010

Hospital Clinico Universitario de Valencia, Valencia

47014

Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS, Meldola

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59037

Hopital Claude Huriez, Lille

61070

Communal Non profit Enterprise Regional Center of Oncology, Kharkiv

69373

Centre Leon Berard, Lyon

75571

APHP - Hopital Saint Antoine, Paris

90110

Songklanagarind Hospital, Songkhla

105229

"Group of companies Medci", Moskva

112201

Taipei Veterans General Hospital, Taipei

119991

First Moscow State Medical University n.a. I.M. Sechenov, Moscow

143422

MEDSI Clinical Hospital on Pyatnitsky Highway, Moscow

168583

National Cancer Centre, Singapore

329563

Curie Oncology, Singapore

450054

Bashkirian Republican Clinical Oncology Dispensary, Ufa

C1426ANZ

Inst. Alexander Fleming, Buenos Aires

F5300COE

Centro Oncologico Riojano Integral (CORI), La Rioja

Unknown

Hospital das Clinicas - UFRGS, Porto Alegre

Ac?badem Altunizade Hastanesi, Istanbul

Van Yuzuncu Yil University Hospital, Van

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

656 53

Masaryk?v onkologický ústav, Brno

779 00

Fakultni nemocnice Olomouc, Olomouc

00100

Aga Khan University Hospital, Nairobi

85-796

Centrum Onkologii w Bydgoszczy, Bydgoszcz

81-519

Szpital Morski im. PCK, Gdynia

31-202

Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II, Krakow

02-034

NIO im Marii Sklodowskiej-Curie, Warsaw

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

08036

Hospital Clínic i Provincial, Barcelona

01230

Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital, Adana

06520

Memorial Ankara Hastanesi, Ankara

NG5 1PB

Nottingham City Hospital, Nottingham

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY