Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites

PHASE2CompletedINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

November 30, 2017

Primary Completion Date

March 21, 2020

Study Completion Date

April 30, 2020

Conditions
Hepatic Ascites
Interventions
DRUG

Oral standard diuretics therapy

Oral standard diuretics therapy (furosemide 40 mg tablet plus spironolactone 100 mg tablet with a dose increase in 40 mg:100 mg ratio) given once daily in the morning for 38 days (from the first day of the study to the end of the study).

DRUG

Hypertonic saline solution

Hypertonic saline solution (150ml, 1.4% - 4.6%) infused slowly over one hour peripherally once daily from the first day of the study for eight days.

DRUG

Etilefrine

Etilefrine 5 mg tablet given by mouth three times daily for 38 days (from the first day of the study to the end of the study).

Trial Locations (1)

32511

National liver institute- menoufiya university, Shibīn al Kawm

All Listed Sponsors
lead

Hala Abd EL-Tawab Ibrahim Radwan

OTHER

NCT04785755 - Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites | Biotech Hunter | Biotech Hunter