Neurotropism and Neuroinflammation in COVID-19 Patients With Delirium.

SARS-CoV-2 quasispecies detection and associated serology testing profiles description (peripheral blood and cerebrospinal fluid - CSF)

systemic and central immune response characterization , associated to the assessment of CNS damage biomarkers (peripheral blood and CSF)

in vivo brain PET-TSPO acquisitions (Positon Emission Tomography using a radioligand that targets the Translocator Protein, which is upregulated in activated microglia)

structural/functional brain MRI assessment (PWI/DWI mismatch imaging, quantification of gray and white matter microstructural integrity, DTI, functional connectivity)

multi-domains neurocognitive assessment