Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,157

Participants

Timeline

Start Date

April 26, 2021

Primary Completion Date

July 6, 2026

Study Completion Date

December 30, 2029

Conditions
Breast Cancer; HER2-positive; Metastatic
Interventions
DRUG

Trastuzumab deruxtecan

Administered by intravenous infusion

DRUG

Placebo

Administered by intravenous infusion

DRUG

Taxane

Investigator's choice of docetaxel or paclitaxel administered by intravenous infusion

DRUG

Pertuzumab

Administered by intravenous infusion

DRUG

Trastuzumab

Administered by intravenous infusion

Trial Locations (283)

100

Research Site, Taipei

235

Research Site, Taipei

333

Research Site, Taoyuan District

1000

Research Site, Manila

1062

Research Site, Budapest

1082

Research Site, Budapest

1112

Research Site, Quezon City

1115

Research Site, Budapest

1122

Research Site, Budapest

1145

Research Site, Budapest

1160

Research Site, Brussels

1200

Research Site, Brussels

1280

Research Site, Ciudad de Buenos Aires

1307

Research Site, Dresden

1414

Research Site, CABA

1500

Research Site, San Juan City

1900

Research Site, La Plata

2013

Research Site, Soweto

2100

Research Site, Copenhagen O

2193

Research Site, Johannesburg

2196

Research Site, Johannesburg

2600

Research Site, Baguio City

2650

Research Site, Edegem

3000

Research Site, Leuven

4000

Research Site, Liège

4400

Research Site, Nyíregyháza

4600

Research Site, San Salvador de Jujuy

5000

Research Site, Namur

Research Site, Szolnok

Research Site, Iloilo City

6000

Research Site, Kecskemét

Research Site, Cebu City

6045

Research Site, Port Elizabeth

6060

Research Site, Charleroi

6400

Research Site, Sønderborg

6529

Research Site, George

7100

Research Site, Vejle

7570

Research Site, Cape Town

7600

Research Site, Mar del Plata

7700

Research Site, Rondebosch

7925

Research Site, Cape Town

8000

Research Site, Davao City

8035

Research Site, Barcelona

8234

Research Site, Cipolletti

9000

Research Site, Ghent

9024

Research Site, Győr

10060

Research Site, Candiolo

10065

Research Site, New York

10117

Research Site, Berlin

10408

Research Site, Goyang-si

10449

Research Site, Taipei

11211

Research Site, Riyadh

11217

Research Site, Taipei

11426

Research Site, Riyadh

11967

Research Site, Shirley

14076

Research Site, Caen

15033

Research Site, Lima

15036

Research Site, Lima

16132

Research Site, Genova

17403

Research Site, York

20089

Research Site, Rozzano

20141

Research Site, Milan

20357

Research Site, Hamburg

20904

Research Site, Silver Spring

22384

Research Site, Jeddah

23214

Research Site, Jeddah

23502

Research Site, Norfolk

24014

Research Site, Roanoke

24127

Research Site, Bergamo

25000

Research Site, Besançon

28041

Research Site, Madrid

28046

Research Site, Madrid

28222

Research Site, Majadahonda

30318

Research Site, Atlanta

31059

Research Site, Toulouse

31096

Research Site, Haifa

31151

Research Site, Cheonan-si

31444

Research Site, Dammam

32909

Research Site, Palm Bay

33030

Research Site, Bordeaux

33100

Research Site, Udine

33161

Research Site, Paderborn

33176

Research Site, Miami

33324

Research Site, Plantation

34070

Research Site, Montpellier

34298

Research Site, Montpellier

35042

Research Site, Rennes

35128

Research Site, Padua

35185

Research Site, Vaxjo

35575

Research Site, Karşıyaka

38138

Research Site, Germantown

39213

Research Site, Jackson

40241

Research Site, Louisville

40443

Research Site, Taichung

41009

Research Site, Seville

41404

Research Site, Daegu

44280

Research Site, Malatya

44680

Research Site, Guadalajara

44805

Research Site, Saint-Herblain

45136

Research Site, Essen

48149

Research Site, Münster

48202

Research Site, Detroit

50080

Research Site, Estado de México

52140

Research Site, Metepec

54519

Research Site, Vandœuvre-lès-Nancy

55200

Research Site, Samsun

57100

Research Site, Livorno

60431

Research Site, Frankfurt am Main

64239

Research Site, Tel Aviv

66278

Research Site, Nuevo León

69120

Research Site, Heidelberg

69495

Research Site, Pierre-Bénite

70403

Research Site, Tainan City

72000

Research Site, Le Mans

72762

Research Site, Springdale

75005

Research Site, Paris

75185

Research Site, Uppsala

75203

Research Site, Dallas

75246

Research Site, Dallas

75702

Research Site, Tyler

76201

Research Site, Denton

77090

Research Site, Houston

77380

Research Site, Shenandoah

78240

Research Site, San Antonio

79110

Research Site, Freiburg im Breisgau

80131

Research Site, Napoli

80501

Research Site, Longmont

84000

Research Site, Avignon

85711

Research Site, Tucson

89128

Research Site, Las Vegas

91054

Research Site, Erlangen

91204

Research Site, Glendale

91206

Research Site, Glendale

91910

Research Site, Veracruz

92210

Research Site, Saint-Cloud

98405

Research Site, Tacoma

100039

Research Site, Beijing

100044

Research Site, Beijing

100191

Research Site, Beijing

110001

Research Site, Shenyang

110075

Research Site, New Delhi

110085

Research Site, New Delhi

116011

Research Site, Dalian

121205

Research Site, Moscow

122001

Research Site, Gūrgaon

129090

Research Site, Moscow

130021

Research Site, Changchun

143442

Research Site, Moscow

150049

Research Site, Harbin

150054

Research Site, Yaroslavl

190020

Research Site, Saint Petersburg

197758

Research Site, Saint Petersburg

200025

Research Site, Shanghai

200032

Research Site, Shanghai

210008

Research Site, Nanjing

210029

Research Site, Nanjing

266100

Research Site, Qingdao

300060

Research Site, Tianjin

310003

Research Site, Hangzhou

310022

Research Site, Hangzhou

330009

Research Site, Nanchang

380060

Research Site, Ahmedabad

400016

Research Site, Chongqing

400030

Research Site, Chongqing

407280

Research Site, Floreşti

410008

Research Site, Changsha

410013

Research Site, Changsha

422009

Research Site, Nashik

422011

Research Site, Nashik

430022

Research Site, Wuhan

430030

Research Site, Wuhan

430060

Research Site, Wuhan

450008

Research Site, Zhengzhou

510060

Research Site, Guangzhou

510080

Research Site, Guangzhou

510120

Research Site, Guangzhou

518036

Research Site, Shenzhen

530021

Research Site, Nanning

560027

Research Site, Bangalore

560099

Research Site, Bengaluru

570017

Research Site, Mysuru

610041

Research Site, Chengdu

650118

Research Site, Kunming

673601

Research Site, Calicut

710004

Research Site, Xi'an

710061

Research Site, Xi'an

750004

Research Site, Yinchuan

4941492

Research Site, Petah Tikva

5266202

Research Site, Ramat Gan

9112001

Research Site, Jerusalem

02215

Research Site, Boston

07901

Research Site, Summit

C1125ABD

Research Site, Buenos Aires

C1012AAR

Research Site, CABA

C1118AAT

Research Site, Caba

C1417DTB

Research Site, Capital Federal

S2000DEJ

Research Site, Rosario

S2002KDS

Research Site, Rosario

88034-000

Research Site, Florianópolis

74000-000

Research Site, Goiânia

86015-520

Research Site, Londrina

59075-740

Research Site, Natal

90035-003

Research Site, Porto Alegre

14015-130

Research Site, Ribeirão Preto

03102-002

Research Site, São Paulo

18030-005

Research Site, Sorocaba

29043-260

Research Site, Vitória

T2N 5G2

Research Site, Calgary

B3H 2Y9

Research Site, Halifax

L4M 6M2

Research Site, Barrie

N2G 1G3

Research Site, Kitchener

L3Y 2P9

Research Site, Newmarket

M2K 1E1

Research Site, North York

M5G 1X5

Research Site, Toronto

H1T 2M4

Research Site, Montreal

H2X 3E4

Research Site, Montreal

H3T 1M5

Research Site, Montreal

H4A 3J1

Research Site, Montreal

G1V 4G2

Research Site, Ste-Foy

S7N 4H4

Research Site, Saskatoon

06189

Research Site, Nice

04103

Research Site, Leipzig

673-8558

Research Site, Akashi-shi

030-8553

Research Site, Aomori

113-8431

Research Site, Bunkyō City

260-8717

Research Site, Chiba

104-0045

Research Site, Chūōku

960-1295

Research Site, Fukushima

350-1298

Research Site, Hidaka-shi

730-8518

Research Site, Hiroshima

734-8551

Research Site, Hiroshima

259-1193

Research Site, Isehara-shi

892-0833

Research Site, Kagoshima

216-8511

Research Site, Kawasaki-shi

650-0047

Research Site, Kobe

135-8550

Research Site, Kōtoku

830-0011

Research Site, Kurume-shi

606-8507

Research Site, Kyoto

791-0280

Research Site, Matsuyama

464-8681

Research Site, Nagoya

467-8602

Research Site, Nagoya

951-8566

Research Site, Niigata

663-8501

Research Site, Nishinomiya-shi

700-8558

Research Site, Okayama

541-8567

Research Site, Osaka

373-8550

Research Site, Ota-shi

003-0804

Research Site, Sapporo

980-8574

Research Site, Sendai

142-8666

Research Site, Shinagawa-ku

160-0023

Research Site, Shinjuku-ku

162-8655

Research Site, Shinjuku-ku

420-8527

Research Site, Shizuoka

514-8507

Research Site, Tsu

241-8515

Research Site, Yokohama

06700

Research Site, Alc. Cuauhtémoc

AREQUIPA01

Research Site, Arequipa

LIMA 29

Research Site, Lima

LIMA 34

Research Site, Lima

011461

Research Site, Bucharest

0081

Research Site, Pretoria

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06273

Research Site, Seoul

06351

Research Site, Seoul

06591

Research Site, Seoul

08308

Research Site, Seoul

03010

Research Site, Alicante

08028

Research Site, Barcelona

08036

Research Site, Barcelona

413 45

Research Site, Gothenburg

701 85

Research Site, Örebro

118 83

Research Site, Stockholm

01330

Research Site, Adana

06520

Research Site, Ankara

06800

Research Site, Ankara

IG9 5HX

Research Site, Buckhurst Hill

EH4 2XU

Research Site, Edinburgh

GU2 7WG

Research Site, Guildford

NW1 2PG

Research Site, London

M20 4BX

Research Site, Manchester

SA2 8QA

Research Site, Swansea

TA1 5DA

Research Site, Taunton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY

NCT04784715 - Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09) | Biotech Hunter | Biotech Hunter