258
Participants
Start Date
July 1, 2021
Primary Completion Date
March 25, 2024
Study Completion Date
March 25, 2024
Magrolimab
Administered intravenously (IV).
Venetoclax
Administered orally at a dose of 100 milligrams (mg) on Day 1, 200 mg on Day 2, 400 mg on Days 3-28 during Cycle 1, followed by 400 mg on Days 1-28 during every cycle (Cycle=28 days).
Azacitidine
Administered either subcutaneously (SC) or IV, 75 milligrams per square meter (mg/m\^2) on Days 1-7 or Days 1-5, 8 and 9 during every cycle (Cycle=28 days).
Cytarabine
"Induction: administered continuous infusion, 100 or 200 mg/m\^2 on Days 1-7 (7+3 induction) and if needed Days 1-5 (5+2 induction) during a cycle (Cycle=Up to 42 Days).~Consolidation: administered IV, 1500 or 3000 mg/m\^2 on Days 1, 3, and 5 once every 12 hours for up to 4 cycles."
Daunorubicin
Administered IV peripherally (IVP), 60 mg/m\^2 on Days 1-3 (7+3 induction) and if needed Days 1-2 (5+2 induction) during a cycle (Cycle=Up to 42 days).
Idarubicin
Administered IV, 12 mg/m\^2 on Days 1-3 (7+3 induction) and if needed Days 1-2 (5+2 induction) during a cycle (Cycle=Up to 42 days).
Steroidal Eye Drops
Administered per institutional standard during consolidation.
Westmead Hospital / Department of Haematology and Bone Marrow Transplantation, Westmead
Calvary Master Newcastle, Waratah
Canberra Hospital, Garran
The Alfred, Melbourne
Hospital General Universitario de Alicante, Alicante
St Vincents Hospital Melbourne, Melbourne
Andrew Love Cancer Centre, University Hospital Geelong, Geelong
Univ. -Klinik für Hämatologie und Internistische Onkologie, Kepler Universitätskilkun GmbHMed, Linz
Universitatsspital Basel - Klinik fur Hamatrologie, Bereich Innere Medizin, Basel
Princess Alexandra Hospital, Woolloongabba
Royal Adelaide Hospital, Adelaide
Odense University Hospital, Odense C
Uniklinikum Salzburg, Universitatsklinik f. Innere Medizin III der PMU, Salzburg
Royal Perth Hospital, Perth
Grand Hôpital De Charleroi - Notre Dame, Charleroi
Fiona Stanley Hospital, Murdoch
CHU Nice - Hopital Archet 1, Nice
Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV, Bruges
AZ Delta vzw, Roeselare
Universitair Ziekenhuis Gent, Ghent
Aalborg University Hospital, Aalborg
Complejo Hospitalario San Pedro de Alcantara, Cáceres
Columbia University Medical Center - Herbert Irving Pavilion, New York
SCDU Ematologia e Terrapie cellulari AO O Ordine Mauriziano Torino, Torino
Institut Paoli Calmettes, Marseille
Dept. of Hematology, Oncology and Tumor Immunology, Charite- University Medicine Berlin, Campus Virchow Klinikum, Berlin
Hospital Universitario Reina Sofia, Córdoba
CHU de Caen, Caen
Roswell Park Cancer Institute, Buffalo
Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Research Organization, Philadelphia
Dept. of Medicine II, University Hospital Hamburg-Eppendorf, Hamburg
ASST Sette Laghi - Ospedale di Circolo e Fondazione Macchi, Varese
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Universitatsklinikum Schleswig-Holstein, Kiel
UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill
Duke Blood Cancer Center, Durham
Hospital Universitario de La Princesa, Madrid
Hospital General Universitario Gregorio Maranon, Madrid
MD Anderson Cancer Center Madrid, Madrid
Hospital Regional Universitario de Malaga, Málaga
St. Francis Cancer Center, Greenville
Prisma Health Cancer Institute, Greenville
Winship Cancer Institute, Atlanta
Clinica Universidad de Navarra - Pamplona (Main Site), Pamplona
IUCT Oncopole, Toulouse
Mayo Clinic Florida, Jacksonville
AdventHealth Orlando, Orlando
Hospital Universitario Central de Asturias, Oviedo
Memorial Cancer Institute, Pembroke Pines
Miami Cancer Institute, Miami
Hopital Haut-Leveque, Pessac
Moffitt Cancer Center, Tampa
Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria
University of Alabama at Birmingham, Birmingham
Complejo Asistencial Universitario de Salamanca - Hsopital Clinico, Salamanca
Department of Hematology and Oncology, Braunschweig Community Hospital, Braunschweig
Hospital U. Marques de Valdecilla, Santander
Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant'Orsola-Malphigi U.O Ematologia, Bologna
"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRS - Oncologia Medica", Meldola
Universitätsklinikum Düsseldorf -Klinik für Hämatologie, Onkologie und Klinische Immunologie, Düsseldorf
University of Kentucky Medical Center, Lexington
The Ohio State University Wexner Medical Center/ James Cancer Hospital, Columbus
CHU de Nantes, Hotel Dieu, Nantes
Hospital Clinico Universitario de Valencia, Valencia
Hospital Universitari I Politècnic La Fe, Valencia
CHU d'Angers, Angers
Universitatsklinikum Koln, Cologne
Uniklinik RWTH Aachen, Medizinische Klunuk IV - Klinik fur Hamatologie, Onkologie, Hamastaseologie und Srammzelltransplantation, Aachen
Froedtert Hospital / Medical College of Wisconsin, Milwaukee
Mayo Clinic Cancer Center Outpatient Pharmacy, Rochester
CHRU Lille - Hospital Claude Huriez, Lille
Northwestern Memorial Hospital/Main Lab, Chicago
The University of Chicago Medical Centre, Chicago
"AORM - AO Riuniti Marche Norde - Pesaro Presidio San Salvatore - Muraglia", Pesaro
SSM Health Saint Louis University Hospital, St Louis
MidAmerica Division, Inc., c/o Research Medical Center, Kansas City
University of Kansas Hospital, Fairway
Klinikum Ludwigshafen Medizinische Klinik A, Ludwigshafen
Universitatsklinikum Heidelberg, Innere Medizin V, Hamatologie, Onkologie und Rheumatologie, Heidelberg
Central Hospital Lyon Sud, Lyon
Tulane Medical center, New Orleans
AOU Consorziale Policlinico Bari, Bari
University of Oklahoma Health Sciences Center - OU Health Stephenson Cancer Center, Oklahoma City
Baylor College of Medicine Medical Center, Houston
The University of Texas MD Anderson Cancer Center, Houston
Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli U.O.S.C. di Ematologia con Trapianto di Midollo Osseo, Napoli
Colorado Blood Cancer Institute, Denver
LMU - Klinikum der Universitat Munchen, Medizinische Klinik und Poliklinik III, Campus Grosshadern, München
Klinikum rechts der Isar der Technischen Universitat Munchen, Klinik und Poliklinik fur Innere Medizin III, München
Huntsman Cancer Institute ,The University of Utah, Salt Lake City
CHU Limoges, Limoges
Universitatsklinikum Ulm, Zentrum fur Innere Medizin, Innere Medizin III, Ulm
USC/ Norris Comprehensive Cancer Center, Los Angeles
Ronald Reagan UCLA Medical Center, Los Angeles
City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte
UC Irvine Health, Orange
Gustave Roussy, Paris
Massachusetts General Hospital, Boston
Dana-Farber Cancer Institute, Boston
Universitair Ziekenhuis Brussel, Brussels
Universitaire Ziekenhuis Antwerpen, Edegem
Hopitaux de Brabois, Vandœuvre-lès-Nancy
Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
Queen Mary Hospital, Hong Kong
Tom Baker Cancer Center, Calgary
Queen Elizabeth II Health Sciences Centre, Halifax
CIUSSS de L'Est-de-L'Ile-de- Montreal - Hopital Maisonneuve-Rosemont, Montreal
McGill University Health Centre, Montreal
Sunnybrook Research Institute, Toronto
Princess Margaret Cancer Centre, Toronto
Universitatsklinikum Carl Gustav Carus Dresden an der Technische Universitat Dresden, Medizinische Klinik und Poliklinik 1, Bereich Hamatologie, Dresden
Azienda Ospedaliero Universitaria delle Marche, Ancona
SC Ematologia, Azienda Ospedaliera di Perugia - Santa Maria della Misericordia, Perugia
Fondazione PTV Policinico Tor Vergata, Roma
Hyogo Prefectural Amagasaki General Medical Center, Amagasaki
Chiba Aoba Municipal Hospital, Chiba
University of Yamanashi Hospital, Chūō
Kyushu University Hospital, Fukuoka
Fukushima Medical University Hospital, Fukushima
Aiiku Hospital, Hokkaido
Tokai University School of Medicine, Isehara
Kanazawa University Hospital, Kanazawa
National Cancer Center Hospital East, Kashiwa
Hospital of the University of Occupational and Environmental Health, Japan, Kitakyushu-shi
Kobe City Medical Center General Hospital, Kobe
Gunmaken Saiseikai Maebashi Hospital, Maebashi
Ehime Prefectural Center Hospital, Matsuyama
Nagasaki University Hospital, Nagasaki
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya
Okayama University Hospital, Okayama
Osaka Metropolitan University Hospital, Osaka
Kindai University Hospital, Sayama
National University Corporation Tohoku University Tohoku University Hospital, Sendai
NTT Medical Center Tokyo, Shinagawa-Ku
Yamagata University Hospital, Yamagata
University of Fukui Hospital, Yoshida-gun
Hospital del la Santa Creu i Sant Pau, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Institut Catala d'Oncologia, Barcelona
Complejo Asistencial Universitario de Burgos/H.U. de Burgos, Burgos
Universitetssjukhus, Hematologimottagnungen, Lund
Inselspital, Universitatsspital Bern - Universitatsklinik fur Medizinisch Onkologie, Bern
University Hospitals Birmingham NHS Foundation Trust, Birmingham
United Lincolnshire Hospitals NHS Trust, Pilgrim Hospital, Sibsey Road, Boston
Cambridge University Hospital NHS Foundation Trust, Cambridge
Cardiff and Vale University Health Board, Cardiff Wales
Barts Health NHS Trust, City of London
NHS Tayside, Dundee
Beatson West of Scotland Cancer Centre, Glasgow
University College London Hospitals NHS Foundation Trust, London
King's College NHS Foundation Trust, London
Oxford University Hospital NHS Foundation Trust, Oxford
The Royal Marsden NHS Foundation Trust, Sutton
The Christie NHS Foundation Trust, Withington
Lead Sponsor
Gilead Sciences
INDUSTRY