A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

586

Participants

Timeline

Start Date

May 5, 2021

Primary Completion Date

September 11, 2024

Study Completion Date

December 30, 2026

Conditions
Parkinsons Disease
Interventions
DRUG

Prasinezumab

Prasinezumab will be administered as an IV infusion to participants Q4W.

DRUG

Placebo

Prasinezumab placebo will be administered to participants.

Trial Locations (110)

1160

Klinik Ottakring, Vienna

1210

Centre Hospitalier de Luxembourg, Luxembourg

6020

Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck, Innsbruck

8036

Medizinische Universität Graz, Graz

8195

Hospital General De Catalunya, Sant Cugat del Vallès

10600

Hospital Virgen del Puerto, Plasencia

13385

hopital de la Timone, Marseille

14226

Dent Neurological Institute, Amherst

15006

Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña

16132

Irccs A.O.U.San Martino Ist, Genoa

19107

University Pennsylvania Hospital, Philadelphia

20014

Policlínica Guipuzkoa, Donosti-San Sebastián

20132

IRCCS Ospedale San Raffaele, Milan

20133

IRCCS Istituto Neurologico Carlo Besta, Milan

23507

Sentara Neurology Specialists, Norfolk

25100

Azienda Ospedaliera Spedali Civili, Brescia

28006

Hospital Ruber Juan Bravo, Madrid

Hospital Universitario de la Princesa, Madrid

28007

Hospital General Universitario Gregorio Marañon, Madrid

28040

Hospital Universitario Clínico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28223

Hospital Quiron de Madrid, Pozuelo de Alarcón

28922

Hospital Universitario Fundación Alcorcón, Alcorcón

28938

HM Universitario Puerta del Sur CINAC (C.Integ.Neuroc);, Móstoles

29010

Hospital Regional Universitario Carlos Haya, Málaga

31008

Clinica Universidad de Navarra, Pamplona

31059

CIC - Hôpital Purpan, Toulouse

32792

Charter Research - Winter Park/Orlando, Winter Park

33000

Groupe Hospitalier Pellegrin, Bordeaux

33462

JEM Research LLC, Atlantis

33486

Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton

34000

CHU Gui de Chauliac, Montpellier

34470

Renstar Medical Research, Ocala

35128

Azienda Ospedaliera di Padova, Padua

35294

University of Alabama at Birmingham, Birmingham

38043

Hôpital Michallon - Centre d'Investigation Clinique, Grenoble

40139

Ospedale Bellaria, Bologna

41009

Hospital Universitario Virgen Macarena, Seville

41013

Hospital Virgen del Rocío, Seville

44195

Cleveland Clinic, Cleveland

44800

CHU de Nantes - Hopital Laennec, Saint-Herblain

46017

Hospital Universitario Dr. Peset, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

48322

Henry Ford Hospital, West Bloomfield

48334

Quest Research Institute, Farmington Hills

48903

Hospital de Cruces, Barakaldo

50012

Servicio de Neurología Hospital Viamed Montecanal., Zaragoza

56126

A.O. Universitaria Pisana, Pisa

60611

Northwestern University Feinberg School Of Medicine, Chicago

62702

Southern Illinois University, School of Medicine, Springfield

63003

Hopital Gabriel Montpied, Clermont-Ferrand

66160

University of Kansas Medical Center, Kansas City

67098

CHU Strasbourg Hpital Hautepierre, Strasbourg

69677

Groupement Hospitalier Est - Hôpital Neurologique, Bron

74136

The Movement Disorder Clinic of Oklahoma, Tulsa

75013

Hopital Pitie-Salpetriere APHP, Paris

75206

Texas Neurology PA, Dallas

76031

CHU Rouen Charles Nicolle, Rouen

77030

Baylor College of Medicine Medical Center, Houston

78681

Central Texas Neurology Consultants, Round Rock

80113

CenExel Rocky Mountain Clinical Research, LLC, Englewood

80138

Università degli studi della Campania Luigi Vanvitelli, Napoli

84131

Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona, Salerno

85013

Barrow Neurological Institute, Phoenix

86021

CHU Poitiers, Poitiers

86077

IRCCS Neuromed, Pozzilli (IS)

87042

CHU de Limoges - Hôpital Dupuytren, Limoges

90033

Keck School of Medicine of USC, Los Angeles

90048

Cedars Sinai Medical Center, Los Angeles

92037

UC San Diego, La Jolla

92835

Neurology Center of North Orange County, Fullerton

94000

Hôpital Henri Mondor, Créteil

94143

University of California San Francisco, San Francisco

95123

"A.O.U. Policlinico G.Rodolico - San Marco", Catania

98034

EvergreenHealth Investigational Drug Services, Kirkland

99202

Inland Northwest Research, Spokane

06510

Institute for Neurodegenerative Disorders, New Haven

33613-4706

University of South Florida, Tampa

02114-2759

Massachusetts General Hospital, Boston

05401

University of Vermont Medical Center, Burlington

M3B 2S7

Toronto Memory Program, Toronto

M5T 2S8

Toronto Western Hospital, Toronto

J8Y 1W2

Clinique Neuro Outaouais, Gatineau

H3A 2B4

Montreal Neurological Institute and Hospital, Montreal

06002

CHU de Nice Hopital Pasteur, Nice

00166

IRCCS San Raffaele;Clinical Trial Center, Rome

00168

Policlinico Universitario Agostino Gemelli, Rome

06156

AO di Perugia - Ospedale S. Maria della Misericordia, Perugia

05100

Azienda Ospedaliera S. Maria, Terni

90-640

NeuroKlinika Gabinet Lekarski Prof. Andrzej Bogucki, ?ód?

85-079

NZOZ Vitamed, Bydgoszcz

80-462

Szpital Sw. Wojciecha, Gda?sk

31-505

Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K, Krakow

20-016

Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak., Lublin

35-232

Nmedis sp. z o.o., Rzeszów

00-416

Samodzielny Publiczny Szpital Kliniczny im. prof. Orlowskiego, Warsaw

01-684

Centrum Medyczne NeuroProtect, Warsaw

03-242

Mazowiecki Szpital Bródnowski w Warszawie Sp. z o.o., Warsaw

03203

Hospital General Universitario de Elche, Elche

08035

Hospital Vall d'Hebron, Barcelona

08036

Hospital Clinic Servicio de Neurologia, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

09006

Hospital Universitario de Burgos. Servicio de Neurología, Burgos

DD2 1SY

Ninewells Hospital, Dundee- Scotland, Dundee

SE5 9RS

Kings College Hospital, London

W6 8RF

Charing Cross Hospital, London

NE4 5PL

Campus for Ageing and Vitality, Newcastle

OX3 7LE

Oxford University Hospitals NHS Foundation Trust, Oxford

PE3 9GZ

North West Anglia NHS Foundation Trust, Peterborough

PL6 8DH

Derriford Hospital, Plymouth

All Listed Sponsors
collaborator

Prothena Biosciences Limited

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY