A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

PHASE3CompletedINTERVENTIONAL
Enrollment

1,036

Participants

Timeline

Start Date

April 19, 2021

Primary Completion Date

September 3, 2024

Study Completion Date

September 3, 2024

Conditions
Neovascular Age-related Macular Degeneration
Interventions
DRUG

Faricimab

Faricimab 6 mg will be administered by intravitreal (IVT) injection into the study eye according to the personalized treatment interval (PTI) dosing regimen for the duration of the study.

OTHER

Sham Procedure

The sham is a procedure that mimics an IVT injection and involves the blunt end of an empty syringe (without a needle) being pressed against the anesthetized eye. The sham procedure will be administered to participants as appropriate during the first 12 weeks of this study in order to maintain the masking of the initial faricimab PTI.

Trial Locations (254)

333

Chang Gung Medical Foundation - Linkou; Ophthalmology, Taoyuan District

500

Changhua Christian Hospital; Department of Ophthalmology, Changhua

1068

Eszak-Pesti Centrumkorhaz - Honvedkorhaz; Szemeszet, Budapest

1090

Medizinische Universität Wien; Universitätsklinik für Augenheilkunde und Optometrie, Vienna

1106

Bajcsy-Zsilinszky Hospital, Budapest

1133

Budapest Retina Associates Kft., Budapest

1309

"Pentagram Eye Hospital (Medical Center Pentagram)", Sofia

1784

Specialized Hospital for Active Treatment of Eye Diseases Zora, Sofia

2000

Sydney Eye Hospital, Sydney

Sydney Retina Clinic and Day Surgery, Sydney

2135

Strathfield Retina Clinic, Strathfield

2145

Sydney West Retina, Westmead

2600

Rigshospitalet Glostrup; Afdeling for Øjensygdomme, Center for Forskning, Glostrup Municipality

2640

Eyeclinic Albury Wodonga, Albury

3002

Centre For Eye Research Australia, East Melbourne

3178

Retina Specialists Victoria, Rowville

4000

Sjællands Universitetshospital, Roskilde; Øjenafdelingen, Roskilde

4032

Debreceni Egyetem Klinikai Kozpont; Szemeszeti Klinika, Debrecen

4102

Vista Klinik Ophthalmologische Klinik, Binningen

6009

The Lions Eye Institute, Nedlands

6720

Szegedi Tudományegyetem ÁOK; Department of Ophtalmology, Szeged

7621

Ganglion Medial Center, Pécs

8036

LKH-Univ.Klinikum Graz; Universitäts-Augenklinik, Graz

8900

Zala Megyei Kórház; SZEMESZET, Zalaegerszeg

11217

Taipei Veterans General Hospital; Ophthalmology, Taipei

11572

Ophthalmic Cons of Long Island, Oceanside

11788

Long Is. Vitreoretinal Consult, Hauppauge

11967

Island Retina, Shirley

12159

The Retina Consultants, Slingerlands

13008

Centre Paradis Monticelli; Ophtalmologie, Marseille

13088

Retina Vit Surgeons/Central NY, Liverpool

14620

Retina Assoc of Western NY, Rochester

15706

Instituto Oftalmologico Gomez Ulla; Servicio de Oftalmologia, Santiago de Compostela

19107

Mid Atlantic Retina - Wills Eye Hospital, Philadelphia

20100

Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico-Clinica Regina Elena;U.O.C Oculistica, Milan

20157

ASST FATEBENEFRATELLI SACCO; Oculistica (Sacco), Milan

20815

Retina Group of Washington, Chevy Chase

21204

Retina Specialists, Towson

21209

The Retina Care Center, Baltimore

21287

Johns Hopkins Med; Wilmer Eye Inst, Baltimore

21740

Cumberland Valley Retina PC, Hagerstown

23502

Wagner Kapoor Institute, Norfolk

24502

Piedmont Eye Center, Lynchburg

28046

Clinica Baviera; Servicio Oftalmologia, Madrid

28210

Char Eye Ear &Throat Assoc, Charlotte

28222

Hospital Universitario Puerta de Hierro, Majadahonda

28602

Graystone Eye, Hickory

28803

Western Carolina Retinal Associate PA, Asheville

29169

Palmetto Retina Center, West Columbia

29456

Charleston Neuroscience Inst, Ladson

30909

Southeast Retina Center, Augusta

31008

Clinica Universitaria de Navarra; Servicio de Oftalmologia, Pamplona

32308

Southern Vitreoretinal Assoc, Tallahassee

32503

Retina Specialty Institute, Pensacola

32901

Florida Eye Associates, Melbourne

33012

Instituto Oftalmologico Fernandez Vega; Servicio de oftalmologia, Oviedo

33064

Rand Eye, Deerfield Beach

33308

Retina Group of Florida, Fort Lauderdale

33324

Fort Lauderdale Eye Institute, Plantation

33410

Retina Care Specialists, Palm Beach Gardens

33609

Retina Associates of Florida, LLC, Tampa

33711

Retina Vitreous Assoc of FL, St. Petersburg

35100

Ege University Medical Faculty; Department of Ophthalmology, Izmir

37203

Tennessee Retina PC., Nashville

37421

Southeastern Retina Associates Chattanooga, Chattanooga

38138

Charles Retina Institute, Germantown

40225

Universitätkslinikum Düsseldorf, Augenklinik; Klinik fürAugenheilkunde, Düsseldorf

41380

Kocaeli University Medical Faculty, Kocaeli

42130

Selcuk University Faculty of Medicine; Department Of Ophthalmology, Konya

42415

Yeungnam University Medical Center, Daegu

43016

Midwest Retina, Dublin

43212

The Ohio State University Havener Eye Institute, Columbus

44093

CHU Nantes - Hôtel Dieu; Ophthalmology, Nantes

44122

Retina Assoc of Cleveland Inc, Cleveland

45242

Cincinnati Eye Institute, Cincinnati

46100

Oftalvist Valencia, Burjassot

46290

Raj K. Maturi, MD PC, Indianapolis

47012

Hospital Universitario Rio Hortega; Servicio de Oftalmologia, Valladolid

48145

Augenabteilung am St. Franziskus-Hospital, Münster

48149

Universitätsklinikum Münster; Augenheilkunde, Münster

49546

Associated Retinal Consultants, Grand Rapids

50009

Hospital Universitario Miguel Servet; Servicio de Oftalmologia, Zaragoza

50266

Wolfe Eye Clinic, West Des Moines

50937

Universitätsklinikum Köln; Augenklinik, Cologne

55435

VitreoRetinal Surgery, PLLC.; DBA Retina Consultants of Minnesota, Edina

56124

Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello; U.O. Oculistica Universitaria, Pisa

57701

Black Hills Eye Institute, Rapid City

60452

University Retina and Macula Associates, PC, Oak Forest

60611

Northwestern Medical Group/Northwestern University, Chicago

62704

Prairie Retina Center, Springfield

63017

Midwest Vision Research Foundation, Chesterfield

63031

Retina Associates of St. Louis, Florissant

64060

Montemayor & Asociados (Oftalmologos), Monterrey Nuevo LEON

66215

Retina Associates, Lenexa

69120

Universitätsklinik Heidelberg; Augenklinik, Heidelberg

69130

Pole Vision Val d'Ouest; Ophtalmologie, Écully

69317

Hopital de la croix rousse; Ophtalmologie, Lyon

75010

Hopital Lariboisiere; Ophtalmologie, Paris

75231

Texas Retina Associates, Dallas

76087

Strategic Clinical Research Group, LLC, Willow Park

76092

Retina Center of Texas, Southlake

77384

Retina Consultants of Houston, The Woodlands

78550

Valley Retina Institute P.A., Harlingen

78750

Austin Clinical Research LLC, Austin

79106

Universitätsklinikum Freiburg, Klinik für Augenheilkunde, Freiburg im Breisgau

79606

Retina Res Institute of Texas, Abilene

80228

Colorado Retina Associates, PC, Lakewood

80909

Retina Consultants of Southern, Colorado Springs

84107

Retina Associates of Utah, PLLC, Salt Lake City

Rocky Mountain Retina, Salt Lake City

85016

Arizona Retina and Vitreous Consultants, Phoenix

85020

Associated Retina Consultants, Phoenix

85206

Barnet Dulaney Perkins Eye Center, Mesa

85704

Retina Associates Southwest PC, Tucson

89502

Sierra Eye Associates, Reno

90033

South Coast Retina Center, Los Angeles

91107

California Eye Specialists Medical group Inc., Pasadena

91436

The Retina Partners, Encino

92064

Retina Consultants, San Diego, Poway

92211

Southern CA Desert Retina Cons, Palm Desert

92373

Retina Consultants of Southern California, Redlands

92705

Orange County Retina Med Group, Santa Ana

93103

California Retina Consultants, Santa Barbara

94010

Chi De Creteil; Ophtalmologie, Créteil

94040

Northern California Retina Vitreous Associates, Mountain View

95008

Retinal Diagnostic Center, Campbell

95817

University of California, Davis, Eye Center, Sacramento

95825

Retinal Consultants Med Group, Sacramento

96701

Retina Consultants of Hawaii, ‘Aiea

97221

Retina Northwest, Portland

98383

Retina Center Northwest, Silverdale

119435

FSBI ?Scientific Research Institute of Eye Diseases? of Russian Academy of medical Sciences, Moscow

124044

Medical Military Academy n.a S.M.Kirov, Saint Petersburg

168751

Singapore Eye Research Institute, Singapore

197022

1 Saint-Petersburg St. Med. University named after academician I.P.Pavlov; Chair of ophathalmology, Saint Petersburg

420066

Clinics of Eye Diseases, LLC, Kazan'

428000

Intersec Research and Technology Complex ?Eye Microsurgery? n.a. S.N. Fyodorov; Cheboksary Branch, Cheboksary

630096

?Intersec Research and Technology Complex Eye Microsurgery n a Fyodorov Novosibirsk Branch, Novosibirsk

3109601

Rambam Medical Center; Opthalmology, Haifa

4941492

Rabin MC; Ophtalmology, Petah Tikva

6423906

Tel Aviv Sourasky MC; Ophtalmology, Tel Aviv

7660101

Kaplan Medical Center; Ophtalmology, Rehovot

9112001

Hadassah MC; Ophtalmology, Jerusalem

06385

Retina Group of New England, Waterford

30060-1137

Georgia Retina PC, Marietta

04101

Maine Eye Center, Portland

02111

Tufts Medical Center; Ophthalmology, Boston

02114

Ophthalmic Consultants of Boston, Boston

08820

NJ Retina, Edison

07666

Retina Associates of NJ, Teaneck

78705-1169

Austin Retina Associates, Austin

77384-4167

Retina Consultants of Texas, The Woodlands

C1017AAO

Fundacion Zambrano, CABA

C1015ABO

Centro Oftalmológico Dr. Charles S.A., Capital Federal

Organizacion Medica de Investigacion, San Nicolás

C1120AAN

Oftalmos, Capital Federal

C1061AAE

Buenos Aires Mácula, Ciudad Autonoma Buenos Aires

M5500GGK

Oftar, Mendoza

S2000DLA

Grupo Laser Vision, Rosario

74980-010

Hospital de Olhos de Aparecida - HOA, Aparecida de Goiânia

04023-062

Universidade Federal de Sao Paulo - UNIFESP*X; Oftalmologia, São Paulo

T2J 0C8

Calgary Retina Consultants, Calgary

V5Z 1M9

University of British Columbia - Vancouver Coastal Health Authority, Vancouver

N6A 4V2

Ivey Eye Institute, London

K2B 7E9

The Retina Centre of Ottawa, Ottawa

M3C 0G9

Toronto Retina Institute, Toronto

J7H 0E8

Institut De L'Oeil Des Laurentides, Boisbriand

J1G 2V4

Michel Giunta Clinique Medical, Sherbrooke

Unknown

Queen Mary Hospital; Department of Ophthalmology, Hong Kong

Hong Kong Eye Hospital; CUHK Eye Centre, Mong Kok

00198

Fondazione G.B. Bietti Per Lo Studio E La Ricerca in Oftalmologia-Presidio Ospedaliero Britannico, Rome

06129

Azienda Ospedaliera di Perugia Ospedale S. Maria Della Misericordia; Clinica Oculistica, Perugia

466-8560

Nagoya University Hospital, Aichi

467-8602

Nagoya City University Hospital, Aichi

480-1195

Aichi Medical University Hospital, Aichi

491-8551

Daiyukai Daiichi Hospital, Aichi

260-8677

Chiba University Hospital, Chiba

285-8741

Toho University Sakura Medical Center, Chiba

812-0011

Hayashi Eye Hospital, Fukuoka

830-0011

Kurume University Hospital, Fukuoka

960-1295

Fukushima Medical University Hospital, Fukushima

060-8604

Sapporo City General Hospital, Hokkaido

078-8510

Asahikawa Medical University Hospital, Hokkaido

660-8550

Hyogo Prefectural Amagasaki General Medical Center (Hyogo AGMC), Hyōgo

663-8501

Hyogo Medical University Hospital, Hyōgo

310-0845

Kozawa eye hospital and diabetes center, Ibaraki

761-0793

Kagawa University Hospital, Kagawa

890-8520

Kagoshima University Hospital, Kagoshima

860-0027

Ideta Eye Hospital, Kumamoto

606-8507

Kyoto University Hospital, Kyoto

514-8507

Mie University Hospital, Mie

889-1692

University of Miyazaki Hospital, Miyazaki

390-8621

Shinshu University Hospital, Nagano

395-8502

Iida Municipal Hospital, Nagano

852-8511

Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki

634-8522

Nara Medical University Hospital, Nara

903-0125

University of the Ryukyus Hospital, Okinawa

530-8480

Kitano Hospital, Osaka

545-8586

Osaka Metropolitan University Hospital, Osaka

570-8507

Kansai Medical University Medical Center, Osaka

573-1191

Kansai Medical University Hospital, Osaka

359-8513

National Defense Medical College Hospital, Saitama

520-2192

Shiga University Of Medical Science Hospital, Shiga

101-8309

Nihon University Hospital, Tokyo

162-8666

Tokyo Women's Medical University Hospital, Tokyo

181-8611

Kyorin University Hospital, Tokyo

193-0998

Tokyo Medical University Hachioji Medical Center, Tokyo

755-8505

Yamaguchi University Hospital, Yamaguchi

06760

Centro Oftalmológico Mira, S.C, Del. Cuauhtemoc

01120

Macula Retina Consultores, Mexico City

3011 BH

Het Oogziekenhuis Rotterdam, Rotterdam

43-309

Szpital sw. Lukasza, Bielsko-Biala

85-631

OFTALMIKA Sp. z o.o, Bydgoszcz

85-870

Specjalistyczny O?rodek Okulistyczny Oculomedica, Bydgoszcz

41-902

Szpital Specjalistyczny nr 1; Oddzial Okulistyki, Bytom

80-402

Dobry Wzrok Sp Z O O, Gda?sk

80-809

Optimum Profesorskie Centrum Okulistyki, Gda?sk

40-594

Gabinet Okulistyczny Prof Edward Wylegala, Katowice

31-070

Centrum Medyczne Dietla 19 Sp. Z O.O., Krakow

31-501

SP ZOZ Szpital Uniwersytecki w Krakowie Oddzia? Kliniczny Okulistyki i Onkologii Okulistycznej, Krakow

42-600

Caminomed, Tarnowskie Góry

53-334

SPEKTRUM Osrodek Okulistyki Klinicznej, Wroclaw

3000-075

Centro Hospitalar E Universitário de Coimbra EPE - Serviço Oftalmologia; Serviço Oftalmologia, Coimbra

4200-319

Hospital de Sao Joao; Servico de Oftalmologia, Porto

602-739

Pusan National University Hospital, Busan

463-707

Seoul National University Bundang Hospital, Seongnam-si

02447

Kyung Hee University Hospital, Seoul

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06192

Nune Eye Hospital; Ophthalmology, Seoul

06351

Samsung Medical Center, Seoul

08907

Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat

08195

Hospital General de Catalunya, San Cugat Del Valles

08022

Institut de la Macula i la retina, Barcelona

08025

Hospital dos de maig; servicio de oftalmologia, Barcelona

08028

Hospital Clinic de Barcelona; Consultas Externas Oftalmologia, Barcelona

06100

Hacettepe University Medical Faculty; Department of Ophthalmology, Ankara

06340

Ankara University Medical Faculty; Department of Ophthalmology, Ankara

06490

Ankara Baskent University Medical Faculty; Department of Ophthalmology, Ankara

06560

Gazi University Faculty of Medicine; Department Of Ophthalmology, Ankara

BD9 6RJ

Opthalmology Research Office, Bradford

BS1 2LX

Bristol Eye Hospital;Retinal Treatment and Research Unit, Bristol

CF14 4XW

University Hospital of Wales, Cardiff

GU16 7UJ

Frimley Park Hospital, Frimley

GL1 3NN

Gloucestershire Hospitals NHS Foundation Trust, Gloucestershire

HU3 2JZ

Hull Royal Infirmary, Hull

LS9 7TF

St James University Hospital, Leeds

L7 8YE

Royal Liverpool University Hospital; St Paul's Clinical Eye Research Centre, Liverpool

EC1V 2PD

Moorfields Eye Hospital NHS Foundation Trust, London

M13 9WL

Manchester Royal Eye Hospital, Manchester

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

SO16 6YD

University Hospital Southampton NHS Foundation Trust; Southampton Eye Unit, Southampton

WV10 0QP

New Cross Hospital, Wolverhampton

YO31 8HE

The York Hospital, York

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY