Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

September 15, 2021

Primary Completion Date

May 17, 2028

Study Completion Date

May 17, 2028

Conditions
HIV-1 Infection
Interventions
DRUG

MK-8591A

FDC tablet of 100 mg doravirine, 0.75 mg islatravir taken orally, once daily for up to 192 weeks

Trial Locations (93)

1211

Hôpitaux Universitaires de Genève (HUG)-Infectious Disease Department ( Site 2004), Geneva

2010

Holdsworth House Medical Practice ( Site 0700), Darlinghurst

St Vincent's Hospital-IBAC ( Site 0702), Sydney

2193

Ezintsha ( Site 2404), Johannesburg

3010

Inselspital Bern-Inselspital Infektiologie ( Site 2003), Bern

4001

King Edward VIII Hospital ( Site 2410), Durban

4031

University Hospital Basel-Infectiology ( Site 2002), Basel

4052

Wentworth Hospital ( Site 2400), Durban

6150

Fiona Stanley Hospital ( Site 0706), Murdock

6903

Ospedale Regionale di Lugano, Sede Civico-Servizio Malattie Infettive ( Site 2005), Lugano

7925

Desmond Tutu Health Foundation ( Site 2402), Cape Town

8011

Christchurch Hospital-Infectious Diseases ( Site 0800), Christchurch

8091

UniversitätsSpital Zürich ( Site 2000), Zurich

9007

Cantonal Hospital St.Gallen ( Site 2001), Sankt Gallen

9300

Josha Research ( Site 2403), Bloemfontein

10029

Icahn School of Medicine at Mount Sinai-Clinical and Translational Research Center ( Site 0006), New York

19104

Penn Medicine: University of Pennsylvania Health System-Perelman Center for Advanced Medicine ( Site, Philadelphia

20005

Whitman-Walker Institute ( Site 0039), Washington D.C.

20007

Georgetown University Medical Center-Clinical Trials Unit Division of Infectious Diseases ( Site 002, Washington D.C.

20127

Ospedale San Raffaele-U.O. Malattie Infettive ( Site 1602), Milan

20157

Ospedale Luigi Sacco-UOC Malattie Infettive I ( Site 1600), Milan

21000

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1516), Dijon

27100

Fondazione IRCCS Policlinico San Matteo-Dipartimento di Malattie Infettive: SC Malattie Infettive (, Pavia

28007

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-Unidad de Enfermedades Infecciosas ( Site 1903), Madrid

28031

Hospital Universitario Infanta Leonor ( Site 1906), Madrid

28040

Hospital Universitario Fundación Jiménez Díaz-Internal Medicine. Infectious disease ( Site 1902), Madrid

28046

Hospital Universitario La Paz-Internal Medicine ( Site 1904), Madrid

30625

Medizinische Hochschule Hannover-Department of Immunology and Rheumatology ( Site 1661), Hanover

31400

CHU de Toulouse-Infectious Disease-Tropical Diseases ( Site 1505), Toulouse

31401

Chatham County Health Department - Chatham CARE Center-Infectious Disease ( Site 0015), Savannah

32803

Orlando Immunology Center ( Site 0017), Orlando

32806

Bliss Healthcare Services-Research ( Site 0030), Orlando

33075

CHU de Bordeaux Hop St ANDRE-Médecine interne et maladies infectieuses ( Site 1512), Bordeaux

33407

Triple O Research Institute, P.A ( Site 0031), West Palm Beach

34090

Hospital La Colombière ( Site 1518), Montpellier

34982

Midway Immunology and Research Center ( Site 0033), Ft. Pierce

59200

Tourcoing Hospital-Service Universitaire des Maladies Infectieuses et du Voyageur ( Site 1519), Tourcoing

60657

Northstar Healthcare ( Site 0003), Chicago

64111

KC CARE Health Center-Clinical Trials ( Site 0012), Kansas City

69004

Hôpital de la Croix Rousse-Service des Maladies infectieuses et tropicales ( Site 1503), Lyon

75010

Hôpital Saint-Louis-Infectious Diseases and tropical diseases ( Site 1511), Paris

75013

Pitie Salpetriere University Hospital-Infectious Disease - Tropical Diseases ( Site 1508), Paris

75018

Hôpital Bichat - Claude-Bernard-infectious diseases ( Site 1523), Paris

75246

North Texas Infectious Diseases Consultants, P.A-Research ( Site 0004), Dallas

76031

CHU Charles Nicolle-Inefectious disease ( Site 1506), Rouen

76104

Texas Center for Infectious Disease Associates-Clinical Research ( Site 0026), Fort Worth

77098

The Crofoot Research Center ( Site 0008), Houston

77401

St Hope Foundation ( Site 0041), Bellaire

85015

Pueblo Family Physicians ( Site 0010), Phoenix

93000

Hôpital Avicenne ( Site 1502), Bobigny

95811

One Community Health ( Site 0045), Sacramento

105275

Moscow Infectious Diseases Clinical Hospital Number 2 ( Site 2306), Moscow

Scientific Advisory Clinical Diagnostic Center Central Resea-Federal AIDS Center ( Site 2302), Moscow

190020

Saint-Petersburg Center for Prophylactic of AIDS and Infecti-Saint-Petersburg Center for Prophylact, Saint Petersburg

196645

Republican Clinical Infectious Hospital ( Site 2300), Saint Petersburg

214006

Smolensk Center for prevention and control of AIDS ( Site 2308), Smolensk

420140

Republican Clinical Hospital for Infectious Diseases A.F. Agafonova ( Site 2303), Kazan'

650056

Kuzbasskiy Center for the Prevention and Control of AIDS ( Site 2305), Kemerovo

660049

Krasnoyarsk Regional Center for the Prevention and Control of AIDS ( Site 2304), Krasnoyarsk

760032

Fundacion Valle del Lili- CIC ( Site 0300), Santiago de Cali

4781151

Hospital hernan henriquez aravena de temuco-Unidad de Investigación Clínica ( Site 0202), Temuco

7500710

Biomedica Research Group-Infectology ( Site 0201), Santiago

8330034

Centro de Investigacion Clinicadela Universidad Catolica ( Site 0204), Santiago

8380420

Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0200), Santiago

08844

ID Care ( Site 0028), Hillsborough

T2R 0X7

Sheldon M. Chumir Health Centre-Southern Alberta Clinic ( Site 0106), Calgary

V6Z 2C7

Vancouver Infectious Diseases Centre ( Site 0100), Vancouver

L8S 1A4

Hamilton Health Sciences- Urgent Care Centre-SIS Clinic ( Site 0109), Hamilton

M5G 1K2

Maple Leaf Research ( Site 0105), Toronto

M5G 2C4

Toronto General Hospital ( Site 0104), Toronto

H2L 4E9

Clinique de médecine Urbaine du Quartier Latin ( Site 0110), Montreal

H2L 4P9

Clinique Medicale lActuel ( Site 0108), Montreal

06202

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 1504), Nice

44093 Cedex 1

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu ( Site 1517), Nantes

00168

Fondazione Policlinico Universitario Agostino Gemelli-UOC Malattie Infettive ( Site 1606), Rome

460-0001

National Hospital Organization Nagoya Medical Center ( Site 0903), Nagoya

160-0023

Tokyo Medical University Hospital ( Site 0904), Shinjuku-ku

162-8655

Center Hospital of the National Center for Global Health and Medicine ( Site 0901), Shinjyuku-ku

540-0006

National Hospital Organization - Osaka National Hospital - Institute For Clinical Research ( Site 09, Osaka

113-8677

Tokyo Metropolitan Komagome Hospital ( Site 0906), Tokyo

50-136

Wrocl.Centr.Zdrowia SPZOZ Osr. Prof-Lecz Ch. Zak. i Terapii Uzaleznien ( Site 1703), Wroclaw

50-220

EMC Instytut Medyczny S. A. Przychodnia przy ul. Lowieckiej we Wroclawiu ( Site 1700), Wroclaw

01-201

Wojewódzki Szpital Zakaźny w Warszawie ( Site 1702), Warsaw

90-001

WSS im. W Bieganskiego O. Chorob Zakaznych i Hepatologii-F ( Site 1701), Ód

0083

Mediclinc Muelmed ( Site 2401), Pretoria

03202

Hospital General Universitario de Elche-Infectius Disease ( Site 1908), Elche

08916

Hospital Germans Trias i Pujol-Fundació Lluita contra la Sida ( Site 1901), Badalona

08036

HOSPITAL CLÍNIC DE BARCELONA-Infection Day Hospital ( Site 1900), Barcelona

BN2 5BE

Brighton and Sussex University Hospitals NHS Trust ( Site 2104), East Sussex

BS10 5NB

Southmead Hospital ( Site 2103), Bristol

NW32QG

Royal Free Hospital ( Site 2102), London

SE5 9RS

King's College Hospital ( Site 2101), London

M8 5RB

North Manchester General Hospital ( Site 2105), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY