Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017)

PHASE3CompletedINTERVENTIONAL
Enrollment

563

Participants

Timeline

Start Date

March 29, 2021

Primary Completion Date

September 27, 2024

Study Completion Date

September 27, 2024

Conditions
Colorectal Neoplasms
Interventions
DRUG

pembrolizumab

IV infusion

DRUG

lenvatinib

oral capsule

DRUG

regorafenib

oral tablet

DRUG

TAS-102 (trifluridine and tipiracil)

oral tablet

Trial Locations (95)

333

Chang Gung Medical Foundation.Linkou Branch ( Site 1902), Taoyuan District

704

NATIONAL CHENG-KUNG UNI. HOSP. ( Site 1904), Tainan City

1431

Centro de Educación Médica e Investigaciones Clínicas (CEMIC)-Medical Oncology ( Site 0303), Buenos Aires

2100

Rigshospitalet ( Site 0702), Copenhagen

2730

Herlev and Gentofte Hospital-Department of Oncology ( Site 0704), Copenhagen

3002

Epworth Freemasons ( Site 1506), Melbourne

3021

Western Health-Sunshine & Footscray Hospitals ( Site 1501), St Albans

4029

Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Si, Brisbane

4120

Gallipoli Medical Research Foundation-GMRF CTU ( Site 1500), Greenslopes

5000

Odense Universitetshospital ( Site 0700), Odense

5011

The Queen Elizabeth Hospital-Cancer Clinical Trials ( Site 1503), Woodville

6009

Hollywood Private Hospital-Medical Oncology ( Site 1507), Perth

10002

National Taiwan University Hospital ( Site 1900), Taipei

10117

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0901), Berlin

11217

Taipei Veterans General Hospital-Oncology ( Site 1901), Taipei

19107

Thomas Jefferson University - Clinical Trials Office ( Site 0027), Philadelphia

21237

MFSMC-HJWCI-Oncology Research ( Site 0012), Baltimore

21239

MedStar Good Samaritan Hospital-Oncology Research ( Site 0038), Baltimore

22030

Trakya University-Oncology ( Site 1303), Edirne

22031

Inova Schar Cancer Institute ( Site 0022), Fairfax

22763

Asklepios Altona-Oncology ( Site 0903), Hamburg

24014

Blue Ridge Cancer Care ( Site 0036), Roanoke

28007

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1205), Madrid

30060

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0021), Marietta

33011

Hospital Universitario Central de Asturias-Digestive ( Site 1200), Oviedo

33332

Onkodok GmbH ( Site 0907), Gütersloh

34457

Acıbadem Maslak Hastanesi ( Site 1307), Istanbul

34668

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1300), Istanbul

34722

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1301), Istanbul

35100

Ege University Medicine of Faculty-Medical Oncology ( Site 1305), Izmir

39008

Hospital Universitario Marqués de Valdecilla ( Site 1201), Santander

40447

China Medical University Hospital-Surgical Department ( Site 1903), Taichung

41014

Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 1207), Seville

44280

İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 1306), Malatya

48202

Henry Ford Hospital ( Site 0024), Detroit

59102

St. Vincent Frontier Cancer Center ( Site 0005), Billings

60637

University of Chicago Medical Center-Medicine - Section of Hematology/Oncology - Gastrointestinal P, Chicago

72764

Klinikum am Steinenberg-Kreiskliniken Reutlingen GmbH ( Site 0908), Reutlingen

81675

klinikum rechts der isar der technischen universität münchen-Klinik und Poliklinik für Innere Mediz, Munich

93940

Pacific Cancer Care ( Site 0031), Monterey

97213

Providence Portland Medical Center ( Site 0019), Portland

98405

Northwest Medical Specialties, PLLC ( Site 0033), Tacoma

105203

The National Medico-Surgical Center N.I. Pirogov ( Site 1102), Moscow

115478

Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF ( Site 1107), Moscow

119991

"First Moscow State Medical University I.M. Sechenov-Interhospital Institution Health Management (", Moscow

188663

SHBI Leningrad Regional Clinical Oncology Dispensary-Clinical Trials Department ( Site 1111), Saint Petersburg

198255

Saint-Petersburg City Clinical Oncology Dispensary-Department of chemotherapy ( Site 1100), Saint Petersburg

310016

Sir Run Run Shaw Hospital-Medical Oncology ( Site 1606), Hangzhou

450054

GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 1109), Ufa

510060

SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 1600), Guangzhou

528041

The First People's Hospital of Foshan-Gastrointestinal oncology ( Site 1604), Foshan

620905

SVERDLOVSK REGIONAL ONCOLOGY DISPENSARY ( Site 1108), Yekaterinburg

2418515

Kanagawa cancer center ( Site 1705), Yokohama

3109601

Rambam Health Care Campus-Oncology ( Site 0800), Haifa

4648681

Aichi Cancer Center Hospital ( Site 1701), Nagoya

5262100

Sheba Medical Center ( Site 0803), Ramat Gan

6423906

Sourasky Medical Center-Oncology ( Site 0801), Tel Aviv

9013102

Shaare Zedek Medical Center-Oncology ( Site 0804), Jerusalem

9112001

Hadassah Medical Center-Oncology ( Site 0802), Jerusalem

C1280AEB

Hospital Británico de Buenos Aires-Oncology ( Site 0308), Ciudad Autónoma de Buenos Aires

C1096AAS

Fundación favaloro para la Docencia e Investigación Médica-Oncología ( Site 0301), Buenos Aires

S2000KZE

Instituto de Oncología de Rosario ( Site 0305), Rosario

C1012AAR

IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 0300), Buenos Aires

T6G 1Z2

Cross Cancer Institute-Department of Medical Oncology ( Site 0207), Edmonton

B3H 2Y9

NSHA-QEII Health Sciences Centre-Dickson Bldg-Dept. of Medical Oncology ( Site 0200), Halifax

L8V 4X2

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0205), Hamilton

M2K1E1

North York General Hospital ( Site 0206), Toronto

H1T 2M4

CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0211), Montreal

G1R 3S1

CHU de Quebec - Université Laval - Hotel Dieu de Quebec-Hemato-Dermato-Gyneco-Oncology ( Site 0203), Québec

DK-7100

Vejle Sygehus-Department of Oncology ( Site 0701), Vejle

277-8577

National Cancer Center Hospital East ( Site 1700), Kashiwa

650-0047

Kobe City Medical Center General Hospital ( Site 1707), Kobe

761-0701

Kagawa University Hospital ( Site 1708), Kita

589-8511

Kindai University Hospital- Osakasayama Campus-Medical Oncology ( Site 1704), Sayama

362-0806

Saitama Prefectural Cancer Center ( Site 1703), Ina-machi

411-8777

Shizuoka Cancer Center ( Site 1706), Nakatogari

811-1395

National Hospital Organization Kyushu Cancer Center ( Site 1709), Fukuoka

104-0045

National Cancer Center Hospital ( Site 1702), Tokyo

135-8550

Japanese Foundation for Cancer Research-GI Oncology ( Site 1710), Tokyo

02841

Korea University Anam Hospital ( Site 1806), Seoul

03080

Seoul National University Hospital-Internal Medicine ( Site 1800), Seoul

03722

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1801), Seoul

05505

Asan Medical Center ( Site 1803), Seoul

06351

Samsung Medical Center-Division of Hematology/Oncology ( Site 1804), Seoul

06591

The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 1802), Seoul

08035

Hospital Universitari Vall d'Hebron-Oncology ( Site 1204), Barcelona

06230

Hacettepe Universitesi-oncology hospital ( Site 1302), Ankara

06520

Memorial Ankara Hastanesi-Medical Oncology ( Site 1304), Ankara

CB2 0QQ

Addenbrooke's Hospital ( Site 1407), Cambridge

NW1 2PG

UCLH-Cancer Clinical Trials Unit ( Site 1400), London

SE1 9RT

Guy's & St Thomas' NHS Foundation Trust ( Site 1404), London

SW3 6JJ

ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 1403), London

EH4 2XU

Western General Hospital ( Site 1401), Edinburgh

SM3 5PT

Royal Marsden Hospital (Sutton) ( Site 1409), London

M20 4BX

The Christie-Medical Oncology ( Site 1411), Manchester

All Listed Sponsors
collaborator

Eisai Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04776148 - Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017) | Biotech Hunter | Biotech Hunter