STEMI Treatment Optimization by Ischemic Postconditioning and IVUS Guidance

NARecruitingINTERVENTIONAL
Enrollment

2,500

Participants

Timeline

Start Date

April 1, 2021

Primary Completion Date

February 1, 2027

Study Completion Date

February 1, 2031

Conditions
ST Elevation Myocardial Infarction
Interventions
PROCEDURE

PCI + Ischemic conditioning

IPOST is repeated for 4 cycles (60 sec obstruction followed by 60 sec perfusion each) and followed by stent implantation with a 1.1/1.0 ratio of stent diameter/reference vessel diameter and a stent length sufficient to cover the entire lesion from healthy to healthy area of the vessel. During the first cycle of re-occlusion of full vessel occlusion is secured by a small injection of contrast.

PROCEDURE

Stent with ultrasound

IVUS catheters are to be advanced at least 20 mm distal to the culprit lesion. After administration of intracoronary nitroglycerine, an IVUS-pullback is to be performed at 0.5mm/second using a commercially available imaging system. Stent size and landing zones are decided based on the IVUS.

Trial Locations (1)

2100

RECRUITING

Heart Center, Rigshospitalet, Copenhagen

All Listed Sponsors
lead

Thomas Engstrom

OTHER