A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

PHASE2RecruitingINTERVENTIONAL
Enrollment

141

Participants

Timeline

Start Date

April 22, 2021

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Low-grade GliomaAdvanced Solid Tumor
Interventions
DRUG

Tovorafenib

Tovorafenib is an oral Type II RAF kinase inhibitor available in 100 mg immediate-release tablet or 25 mg/milliliter (mL) powder for reconstitution.

Trial Locations (35)

2145

RECRUITING

The Children's Hospital at Westmead, Westmead

3052

RECRUITING

Royal Children's Hospital, Parkville

3080

RECRUITING

Seoul National University Hospital, Seoul

3722

RECRUITING

Severance Hospital - Yonsei University, Seoul

4101

RECRUITING

Queensland Children's Hospital, Brisbane

8032

RECRUITING

Universitäts-Kinderspital Zürich - Eleonorenstiftung, Zurich

10016

RECRUITING

NYU Langone Health, New York

13353

RECRUITING

Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Otto-Heubner-Centrum für Kinder, Berlin

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21231

TERMINATED

Johns Hopkins Hospital, Baltimore

27710

RECRUITING

Duke Cancer Center, Durham

48109

RECRUITING

CS Mott Children's Hospital, Ann Arbor

60611

RECRUITING

Lurie Children's Hospital of Chicago, Chicago

63110

RECRUITING

St. Louis Children's Hospital, St Louis

69120

RECRUITING

Hopp-Kindertumorzentrum Heidelberg (KiTZ), KiTZ Clinical Trial Unit (ZIPO), Heidelberg

77030

RECRUITING

Texas Children's Hospital, Houston

84113

RECRUITING

University of Utah, Salt Lake City

94143

RECRUITING

UCSF Benioff Children's Hospital, San Francisco

97239

TERMINATED

Doernbecher Children's Hospital Oregon & Health Science University, Portland

98105

RECRUITING

Seattle Children's Hospital, Seattle

229899

RECRUITING

KK Women's and Children's Hospital, Singapore

3109601

RECRUITING

Rambam Health Care Campus, Haifa

4920235

RECRUITING

Schneider Children's Medical Center of Israel, Petah Tikva

5265601

RECRUITING

The Chaim Sheba Medical Center, Ramat Gan

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

WA 6009

RECRUITING

Perth Children's Hospital, Perth

NSW 2031

RECRUITING

Sydney Children's Hospital, Randwick

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Ste-Justine, Montreal

H4A 3J1

RECRUITING

Montreal Children's Hospital, Montreal

G1V 4G2

RECRUITING

Centre Mère-Enfant Soleil du CHU, Québec

Unknown

RECRUITING

Rigshospitalet, Copenhagen

3584 CS

RECRUITING

Princess Maxima Center for Pediatric Oncology, Utrecht

WC1N 1EH

RECRUITING

UCL Great Ormond Street Institute of Child Health, London

NE1 7RU

RECRUITING

Newcastle University, Newcastle upon Tyne

All Listed Sponsors
collaborator

Pacific Pediatric Neuro-Oncology Consortium

OTHER

lead

Day One Biopharmaceuticals, Inc.

INDUSTRY

NCT04775485 - A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors | Biotech Hunter | Biotech Hunter