Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.

CompletedOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

December 11, 2020

Primary Completion Date

March 30, 2021

Study Completion Date

May 30, 2021

Conditions
ElectroencephalographyAgingPropofolDepth of Anesthesia
Interventions
DRUG

Propofol

Propofol will be started at a rate of 15-20 mg/kg/hr in patients \>65 years and 20-25 mg/kg/hr in younger patients (\<65 years) until a suppression rate (SR) is achieved. If not, can be increased by 5 mg/kg/hr every 5 minutes up to 25 mg/kg/hr in the elderly group and 30 mg/kg/hr in the younger group or after 15 minutes have passed. When the SR appears, propofol infusion will be stopped. Then restarted at half of the initial rate. Maintenance of anesthesia will be guided by Sedline Monitor to maintain an alpha band present in the spectrogram and SEF95 between 8-12 Hz. BIS monitor will be covered. Both EEG signals (Sedline and BIS) will be registered simultaneously until the patient's extubation.

Trial Locations (1)

8330024

Division de Anestesia - Pontificia Universidad Catolica de Chile, Santiago

All Listed Sponsors
lead

Pontificia Universidad Catolica de Chile

OTHER

NCT04774120 - Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients. | Biotech Hunter | Biotech Hunter