11
Participants
Start Date
February 8, 2022
Primary Completion Date
December 11, 2023
Study Completion Date
February 15, 2024
Microbiological analysis of periprosthetic tissue
Microbiological culture of tissue samples collected intraoperatively from the newly-formed joint capsule, between prosthesis stem and femoral bone, and between the acetabular prosthesis and iliac bone.
Histological analysis of periprosthetic tissue
Histological assessment of cellular reactivity associated with the infection on tissue samples collected intraoperatively from the newly-formed joint capsule, between prosthesis stem and femoral bone, and between the acetabular prosthesis and iliac bone.
Characterization of tissue microbiota
"Assessment of tissue microbiome composition using the next-generation sequencing of DNA extracted from samples collected intraoperatively from the newly-formed joint capsule, between prosthesis stem and femoral bone, and between the acetabular prosthesis and iliac bone."
Characterization of gut microbiota
"Assessment of gut microbiome composition using the next-generation sequencing of DNA extracted from stool samples."
Characterization of oral microbiota
"Assessment of oral microbiome composition using the next-generation sequencing of DNA extracted from a buccal swab obtained by rubbing the mucosa of cheeks, gingivae, and palate."
Istituto Ortopedico Rizzoli, Bologna
Istituto Ortopedico Rizzoli
OTHER