Fear and Avoidance in PTSD Patients

NARecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

September 9, 2021

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Post Traumatic Stress Disorder
Interventions
BEHAVIORAL

Fear Conditioning

Participants will be administered increasing intensities of mild electric shock via electrodes connected to the foot. New Biopac stimulators that can deliver higher shock intensity, provided participants agreement will be used to assure adequate conditioning levels. Stimulation is measures in milliamps (mA), and each delivered stimulation will be 0.5 seconds long (500 milliseconds). To colored (blue, red, \& yellow) light stimuli (CS). The light stimulus is followed by a shock or no shock depending on color.

OTHER

Avoidance conditioning

Via button pressing. Only one stimulus-CS will enable control over experiencing the shock: the participant can press the button during the first 2 seconds of the light presentation to avoid the shock.

OTHER

Pavlovian fear extinction learning

After avoidance conditioning, the CS+ associated with avoidance responding appears with no button to press and no shock is administered.

OTHER

Willingness to pay to avoid shock

On the next day, participants receive a monetary stipend to use to pay to guarantee that they are not to receive any shocks if they press a button from the CS+. This and all previously described experimental phases noted above will occur inside of the fMRI scanner.

Trial Locations (1)

77054

RECRUITING

UTHealth Houston, Houston

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

The University of Texas Health Science Center, Houston

OTHER