300
Participants
Start Date
September 9, 2021
Primary Completion Date
January 31, 2027
Study Completion Date
January 31, 2027
Fear Conditioning
Participants will be administered increasing intensities of mild electric shock via electrodes connected to the foot. New Biopac stimulators that can deliver higher shock intensity, provided participants agreement will be used to assure adequate conditioning levels. Stimulation is measures in milliamps (mA), and each delivered stimulation will be 0.5 seconds long (500 milliseconds). To colored (blue, red, \& yellow) light stimuli (CS). The light stimulus is followed by a shock or no shock depending on color.
Avoidance conditioning
Via button pressing. Only one stimulus-CS will enable control over experiencing the shock: the participant can press the button during the first 2 seconds of the light presentation to avoid the shock.
Pavlovian fear extinction learning
After avoidance conditioning, the CS+ associated with avoidance responding appears with no button to press and no shock is administered.
Willingness to pay to avoid shock
On the next day, participants receive a monetary stipend to use to pay to guarantee that they are not to receive any shocks if they press a button from the CS+. This and all previously described experimental phases noted above will occur inside of the fMRI scanner.
RECRUITING
UTHealth Houston, Houston
National Institute of Mental Health (NIMH)
NIH
The University of Texas Health Science Center, Houston
OTHER