An Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan (APL-2) in Subjects With Geographic Atrophy Secondary to AMD

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,200

Participants

Timeline

Start Date

March 4, 2021

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2026

Conditions
Geographic Atrophy Secondary to Age-related Macular Degeneration
Interventions
DRUG

PEGCETACOPLAN (APL-2)

Complement (C3) Inhibitor

Trial Locations (175)

1425

Diagnostico Ocular, Buenos Aires

2000

Microcirujia Ocular Rosario, Rosario

Sydney Retina, Sydney

2135

Strathfield Retina Clinic, Strathfield

2145

The Ashley Centre, Westmead

Save Sight Institute, Westmead

2150

Marsden Eye Specialist, Parramatta

2220

Retina and Eye Consultantss, Hurstville

3002

Centre for Eye Research Australia, East Melbourne

3204

Hamilton Eye Clinic, Hamilton

5000

Instituto Oftalmologico de Cordoba, Córdoba

5500

OFTAR, Mendoza

6009

Lions Eye Institute, Nedlands

8013

Southern Eye Specialists, Christchurch

10022

Vitreous Retina Macula Consultants of New York, New York

10034

University hospital Kralovske Vinohrady, Prague

11021

Long Island Vitreoretinal Consultants, Great Neck

11572

Ophthalmic Consultants of Long Island, Oceanside

13008

Centre monticelli Paradis, Marseille

15122

AIO Visionary Eye Care, West Mifflin

15146

Retina Vitreous Consultants, Monroeville

15706

Instituto Oftalmologico Gomez-Ulla, Santiago de Compostela

18107

Mid Atlantic Retina, Bethlehem

19006

Mid Atlantic Retina, Philadelphia

19107

Mid Atlantic Retina, Philadelphia

20132

IRCCS San Raffaele, Milan

20157

ASST Fatebenefratelli-Sacco Ospedale Luigi Sacco, Milan

21209

The Retina Care Center, Baltimore

21236

Elman Retina Group, Baltimore

21740

Cumberland Valley Retina Center, Hagerstown

Mid Atlantic Retina Specialist, Hagerstown

22031

The Retina Group of Washington, Fairfax

22046

Emerson Clinical Research Institute, Falls Church

22903

University of Virginia, Charlottesville

23538

Universitatsklinikum Schleswig-Holstein, Lübeck

27710

Duke University, Duke Eye Center, Durham

28210

Charlotte Eye Ear Nose and Throat Associates, PS, Charlotte

28222

Hospital Universitario Puerta de Hierro, Madrid

28602

Graystone Eye, Hickory

28803

Western Carolina Retinal Associates, Asheville

30060

Georgia Retina, PC, Marietta

30909

Southeast Retina Center, PC, Augusta

32503

Retina Specialty Institute, Pensacola

33076

CHU de Bordeaux, Bordeaux

33136

Bascom Palmer Eye Institute, Miami

33309

Pinnacle Research Insitute, Fort Lauderdale

33418

Palm Beach Gardens, Palm Beach Gardens

33426

Florida Eye Microsurgical Institute, Inc., Boynton Beach

33609

Retina Associates of Florida, Tampa

33612

University of South Florida, Tampa

33761

Blue Ocean Clinical Research, Clearwater

33782

Eye Associates of Pinellas, Pinellas Park

33880

Center for Retina and Macular Disease, Winter Haven

33907

Retina Health Center, Fort Myers

33912

National Opthalmic Research Institute, Fort Myers

34103

Bascom Palmer Eye Institute at Naples, Naples

34994

East Florida Eye Institute, Stuart

37075

Uni-medizin Gottingen Augenklinik 3.B1.261, Göttingen

37540

Centre ophtalmologique Saint-Exupery, Saint-Cyr-sur-Loire

38138

Charles Retina Institute, Germantown

40509

Retina and Vitreous Associates of Kentucky, PSC dba Retina Associates of Kentucky, Lexington

43212

The Ohio State University, Columbus

44093

CHU de Nantes - Hotel Dieu, Nantes

44122

Retina Associates of Cleveland, Inc., Cleveland

44130

Retina Associates of Cleveland, Cleveland

44195

Cleveland Clinic Cole Eye Institute, Cleveland

44505

Retina Associates of Cleveland, Inc., Youngstown

46290

Midwest Eye Institute, Indianapolis

48105

Michigan Medicine Kellogg Eye Center, Ann Arbor

48145

Augenzentrum am St. Franziskus-Hospital, Münster

Universitatsklinikum Regensburg, Münster

48149

Universitatsklinikum Munster, Münster

49546

Associated Retinal Consultants, PC, Grand Rapids

49686

Associated Retinal Consultants, PC, Traverse City

50937

Uniklinik Koln, Cologne

53127

Universitats-Augenklinik Bonn, Bonn

53705

Retina Health Center, Madison

Retina-Vitreous Associates Medical Group, Madison

55435

Vitreoretinal Surgery, Minneapolis

57701

Black Hills Regional Eye Institute, Rapid City

60611

Northwestern Feinberg School of Medicine, Chicago

60612

Rush University Medical Center, Chicago

61704

Gailey Eye Clinic Retina Center, Bloomington

64239

Tel Aviv Sourasky Medical Center, Tel Aviv

67000

Maison Rouge Ophthalmologic Center, Strasbourg

67063

Klinikum der Stadt Ludwigshafen gGmbH, Ludwigshafen

67091

CHU de Strasbourg Hopital Civil, Strasbourg

69004

Hopital de la Croix-Rousse, Lyon

69130

Clinique du Val d'Ouest, Écully

72076

STZ Eyetrial, Tübingen

73013

Retina Vitreous Center, PLLC, Edmond

75006

Centre Ophtalmol de l Odeon, Paris

75010

Hopital Lariboisiere, Paris

75012

CHNO des Quinze-Vingts, Paris

75015

Centre Ophtalmo. Image/Laser, Paris

75231

Texas Retina Associates, Dallas

77025

Houston Eye Associates, Houston

77030

Retina Consultants of Houston, PA, Houston

77384

Retina Consultants of Houston, The Woodlands

77401

Brown Retina Institute, Bellaire

78240

Medical Center Ophthalmology Associates, San Antonio

Retina Associates of South Texas, San Antonio

78503

Tennessee Retina, PC, Nashville

Valley Retina Institute, McAllen

78750

Retina Research Center PLLC, Austin

79106

University Opthalmology Clinic, Freiburg im Breisgau

80336

Augenklinik der LMU Munchen, München

81301

Southwest Retina Research Center, LLC, Durango

81675

Klinikum rechts der Isar, München

84107

Retina Associates of Utah, PC, Murray

84312

University of Utah - John A. Moran Center, Salt Lake City

85014

Retinal Research Institue, LLC, Phoenix

85020

Associated Retina Consultants, Ltd., Phoenix

87109

Vision Research Center Eye Associates of NM, Albuquerque

89503

Sierra Eye Associates, Reno

90033

Doheny Eye Center UCLA, Los Angeles

91120

Hadassah Medical Center, Jerusalem

91436

The Retina Partners, Encino

92064

Retina Consultants San Diego, Poway

92093

Jacobs Retina Center, UCSD, La Jolla

92260

Retina Institute of California Medical Group, Palm Desert

92647

Atlantis Eyecare, Huntington Beach

92705

Orange County Retina Medical Group, Santa Ana

The Retina Group of Washington, Chevy Chase

92835

Retina Consultants of Orange County, Fullerton

93103

California Retina Consultants, Santa Barbara

93309

California Retina Consultants, Bakersfield

94010

Centre Hospitalier Intercommunal de Creteil, Créteil

94040

Northern California Retina Vitreous Associates, Mountain View

94303

Byers Eye Institute, Stanford University, Palo Alto

94598

Bay Area Retina Associates, Walnut Creek

95508

Retinal Diagnostic Center, Campbell

97221

Retina Northwest, PC, Portland

97225

Eye Health Northwest, Portland

97405

Oregon Retina LLP, Eugene

98004

Vitreoretinal Associates of Washington, Bellevue

99204

Spokane Eye Clinical Research, Spokane

3109601

Rambam Health Care Campus, Haifa

7030000

Assaf ha Rofeh MC, Be’er Ya‘aqov

06810

Danbury Eye Physicians & Surgeons, PC, Danbury

06835

Retina Group of New England - New London, Waterford

02114

Ophthalmic Consultants of Boston, Boston

02116

Tufts Medical Center, Boston

01107

New England Retina Consultants, PC, Springfield

07003

Retina Center of NJ, LLC, Bloomfield

07666

NJ Retina, Teaneck

08755

NJ Retina, Toms River

C1015 ABO

Organizacion Medica de Investigacion (OMI), Buenos Aires

C1023 AAQ

Fundacion Zambrano, Buenos Aires

C1116ABA

Centro Oftalmologico Dr. Charles S.A., Buenos Aires

S2000

Oftalmologos Especialistas, Santa Fe

04038-032

IPEPO Instituto Da Visao, São Paulo

N6A 4V2

Ivey Eye Institute, London

K1H 8L6

University of Ottawa Eye Institute, Ottawa

K2B 7E9

Retina Centre of Ottawa, Ottawa

708 52

Fakultni Nemocnice Ostrava, Ostrava-Poruba

150 00

AXON Clinical, s.r.o., Prague

2128 08

Vseobecna fakultni nemocnice v Praze, Prague

760 01

Gemini Eye Clinic, Zlín

21 079

CHU Dijon, Dijon

1105 AZ

Academisch Medisch Centrum, Amsterdam

6525 EX

Radboud university medical center Oogheelkunde, Nijmegen

85-316

Eye Surgery Center Professor Zagorski, Bydgoszcz

85-631

Oftalmika Eye Hospital, Bydgoszcz

35-017

Grupo Laser Vision, Rzeszów

33-100

Oculomedica Eye Centre, Tarnów

UNO-MED Centrum Medyne, Tarnów

SE5 9RS

Kings College Hospital NHS Trust, London

HD3 3EA

Huddersfield Royal Infirmary, Huddersfield

LS9 7TF

St James's University Hospital, Leeds

BS1 2LX

Bristol Eye Hospital, Bristol

L7 8XP

Royal Liverpool University Hospital, Liverpool

W1G 7LA

London Vision Clinic, London

OX3 9DU

Oxford Eye Hospital, Oxford

SR2 9HP

Sunderland Eye Infirmary, Sunderland

Sponsors
All Listed Sponsors
lead

Apellis Pharmaceuticals, Inc.

INDUSTRY