The Value of Central Venous-arterial Carbon Dioxide Difference

NACompletedINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

January 1, 2017

Primary Completion Date

December 30, 2019

Study Completion Date

December 30, 2019

Conditions
Jugular VeinsRadial ArteryCarbon Dioxide
Interventions
DRUG

Goal-directed fluid therapy (GDET)

Compensatory dilatation was performed firstly and 5ml/kg crystal solution was added within 30min before induction of anesthesia.When SVV≥13%, infusion of colloidal solution 2ml/kg was performed 15-20 minutes.If the increase of SV was≥10% after the liquid impact and the SVV was still≥13%, the colloidal solution was used again for 2mL/kg and the infusion was maintained until the SVV \< 13%.The infusion was stopped when the SVV \< 10%.If the increase of SV was less than 10% or CI \< 2.0L/min/m2 after infusion, dobutamine was given intravenously to observe the change of SV. If the increase of SV was greater than 10%, dobutamine could be maintained and the above fluid regimen continued.If the increase of SV was less than 10% and MAP≥65mmHg, the infusion of liquid was stopped and replaced with 4ml/kg/h infusion for maintenance.If the increase of SV was less than 10% and MAP was less than 65mmHg, the infusion was suspended.

All Listed Sponsors
lead

Liang Bing

OTHER

NCT04761237 - The Value of Central Venous-arterial Carbon Dioxide Difference | Biotech Hunter | Biotech Hunter