244
Participants
Start Date
October 5, 2021
Primary Completion Date
December 31, 2026
Study Completion Date
December 31, 2026
Biospecimen Collection
Undergo blood and CSF sample collection
Bone Marrow Aspiration
Undergo bone marrow biopsy and aspiration
Bone Marrow Biopsy
Undergo bone marrow biopsy and aspiration
Computed Tomography
Undergo CT or PET/CT
Cyclophosphamide
Given IV
Doxorubicin Hydrochloride
Given IV
Echocardiography Test
Undergo ECHO
Etoposide Phosphate
Given IV
Filgrastim
Given SC
Lumbar Puncture
Undergo LP
Nivolumab
Given IV
Pegfilgrastim
Given SC
Positron Emission Tomography
Undergo PET/CT
Prednisolone
Given PO
Prednisone
Given PO
Radiation Therapy
Undergo radiation therapy
Rituximab
Given IV
Rituximab and Hyaluronidase Human
Given SC
Vincristine Sulfate
Given IV
The Children's Hospital at Westmead, Westmead
John Hunter Children's Hospital, Hunter Regional Mail Centre
Royal Children's Hospital, Parkville
Queensland Children's Hospital, South Brisbane
Perth Children's Hospital, Perth
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Memorial Sloan Kettering Cancer Center, New York
NYP/Weill Cornell Medical Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
Memorial Sloan Kettering Westchester, Harrison
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Memorial Sloan Kettering Nassau, Uniondale
Memorial Sloan Kettering Commack, Commack
Stony Brook University Medical Center, Stony Brook
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
Wilmot Cancer Institute at Webster, Webster
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Geisinger Medical Center, Danville
Lehigh Valley Hospital-Cedar Crest, Allentown
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
University of Maryland/Greenebaum Cancer Center, Baltimore
Greater Baltimore Medical Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Fairfax Hospital, Falls Church
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
West Virginia University Charleston Division, Charleston
Wake Forest University Health Sciences, Winston-Salem
East Carolina University, Greenville
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
AdventHealth Hendersonville, Hendersonville
Mission Hospital, Asheville
AdventHealth Infusion Center Asheville, Asheville
Prisma Health Richland Hospital, Columbia
Saint Francis Hospital, Greenville
BI-LO Charities Children's Cancer Center, Greenville
Saint Francis Cancer Center, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Emory Proton Therapy Center, Atlanta
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
University of Florida Health Science Center - Gainesville, Gainesville
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Broward Health Medical Center, Fort Lauderdale
Tampa General Hospital, Tampa
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
USA Health Strada Patient Care Center, Mobile
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Greater Dayton Cancer Center, Kettering
Dayton Physician LLC - Englewood, Dayton
Kettering Medical Center, Kettering
Riley Hospital for Children, Indianapolis
Reid Health, Richmond
Corewell Health Children's, Royal Oak
C S Mott Children's Hospital, Ann Arbor
Children's Hospital of Michigan, Detroit
Henry Ford Hospital, Detroit
Michigan State University, East Lansing
Bronson Methodist Hospital, Kalamazoo
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
Blank Children's Hospital, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
Siouxland Regional Cancer Center, Sioux City
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Marshfield Medical Center-Marshfield, Marshfield
United Hospital, Saint Paul
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Minnesota Oncology - Burnsville, Burnsville
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
Abbott-Northwestern Hospital, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Sanford Broadway Medical Center, Fargo
Northwestern Medicine Lake Forest Hospital, Lake Forest
Advocate Children's Hospital-Park Ridge, Park Ridge
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Northwestern Medicine Cancer Center Delnor, Geneva
Loyola University Medical Center, Maywood
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Rush-Copley Medical Center, Aurora
Northwestern Medicine Cancer Center Warrenville, Warrenville
Lurie Children's Hospital-Chicago, Chicago
Northwestern University, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Carle Cancer Center, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
HSHS Saint Elizabeth's Hospital, O'Fallon
Carle Physician Group-Effingham, Effingham
Decatur Memorial Hospital, Decatur
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Saint Luke's Hospital, Chesterfield
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Children's Mercy Hospitals and Clinics, Kansas City
Wesley Medical Center, Wichita
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
Houston Methodist Hospital, Houston
M D Anderson Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Texas Tech University Health Sciences Center-Amarillo, Amarillo
Covenant Children's Hospital, Lubbock
UMC Cancer Center / UMC Health System, Lubbock
El Paso Children's Hospital, El Paso
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
Banner Children's at Desert, Mesa
Banner University Medical Center - Tucson, Tucson
Presbyterian Hospital, Albuquerque
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Renown Regional Medical Center, Reno
Children's Hospital Los Angeles, Los Angeles
Cedars Sinai Medical Center, Los Angeles
Mattel Children's Hospital UCLA, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Miller Children's and Women's Hospital Long Beach, Long Beach
City of Hope Comprehensive Cancer Center, Duarte
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
City of Hope at Irvine Lennar, Irvine
UC Irvine Health Cancer Center-Newport, Costa Mesa
Children's Hospital of Orange County, Orange
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Valley Children's Hospital, Madera
Lucile Packard Children's Hospital Stanford University, Palo Alto
Kaiser Permanente-Oakland, Oakland
University of California Davis Comprehensive Cancer Center, Sacramento
Kapiolani Medical Center for Women and Children, Honolulu
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Valley Medical Center, Renton
Seattle Children's Hospital, Seattle
Mary Bridge Children's Hospital and Health Center, Tacoma
Madigan Army Medical Center, Tacoma
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Providence Alaska Medical Center, Anchorage
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Walter Reed National Military Medical Center, Bethesda
Tufts Medical Center, Boston
Dana-Farber Cancer Institute, Boston
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Memorial Sloan Kettering Basking Ridge, Basking Ridge
Hackensack University Medical Center, Hackensack
Memorial Sloan Kettering Monmouth, Middletown
Memorial Sloan Kettering Bergen, Montvale
Morristown Medical Center, Morristown
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey, New Brunswick
Saint Joseph's Regional Medical Center, Paterson
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Alberta Hospital, Edmonton
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
HIMA San Pablo Oncologic Hospital, Caguas
National Cancer Institute (NCI)
NIH