The Clinical Impact of L-PRF, H-PRF or the Use of Surgical Stent on Palatal Donor Site Healing.

PHASE1CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

February 24, 2021

Primary Completion Date

May 25, 2023

Study Completion Date

May 25, 2023

Conditions
Lack of Keratinized Gingiva
Interventions
BIOLOGICAL

L-PRF (Leucocyte- platelet rich fibrin)

Leucocyte-Platelet rich fibrin is a high density fibrin clot. it serves as a biological healing matrix by supporting cell migration and cytokine release, expanding the range of its potential applications greatly. Patient's own blood is centrifuged using (Intra-spin) FDA approved centrifuge on 45 degrees angle on 2700 rpm for 12 minutes.

BIOLOGICAL

H-PRF (Horizontal -platelet rich fibrin)

Platelet rich fibrin is a high density fibrin clot. it serves as a biological healing matrix by supporting cell migration and cytokine release, expanding the range of its potential applications greatly.Horizontally centrifuged platelet rich fibrin using (Bio-prf) centrifuge on 700 g force for 8 minutes. On a horizontal centrifugation, the cells separate much more efficiently throughout the entire membrane. This leads to better layer separation and also favors cells that are evenly distributed throughout the PRF clot.

DEVICE

Surgical stent

An essix surgical stent will be obtained using a high vacuum suction and used to protect the denuded donor site after suturing the wound. (Biostar® Scan/Biostar®V) will be used to make the stent.

Trial Locations (1)

40536

University of Kentucky, Lexington

All Listed Sponsors
lead

Abdo Y Ismail

OTHER

NCT04758702 - The Clinical Impact of L-PRF, H-PRF or the Use of Surgical Stent on Palatal Donor Site Healing. | Biotech Hunter | Biotech Hunter