Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV Astrocytoma

PHASE1CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

May 14, 2021

Primary Completion Date

June 7, 2023

Study Completion Date

June 7, 2023

Conditions

Grade III AstrocytomaGrade IV AstrocytomaAstrocytoma, Grade IVAstrocytoma, Grade III

Interventions

DRUG

Tadalafil

Tadalafil is commercially available and will be purchased by the Siteman Cancer Center and distributed to participants free of charge.

Trial Locations (1)

Washington University School of Medicine, St Louis

All Listed Sponsors

lead

Washington University School of Medicine

OTHER