Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope

NARecruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

March 24, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Syncope, NeurogenicSyncope
Interventions
PROCEDURE

EPS, electro-anatomical mapping, ARGP ablation, and pharmacological evaluation.

EPS and electro-anatomical mapping of the right atrium and the surrounding veins. A target line (TL) is traced at the posteroseptal side of the junction, between the right atrium and superior vena cava, facing the mid and caudal parts of the right superior pulmonary vein antrum on the right heart cavities on a CT image imported into the CARTO system. This map will be carefully merged with the CT image and the TL will be visible. Sequential ablations will be delivered along theTL until the procedure endpoint is reached. Pharmacological evaluation.

PROCEDURE

EPS, electro-anatomical mapping, and pharmacological evaluation.

EPS and electro-anatomical mapping of the right atrium and the surrounding veins. A target line (TL) is traced at the posteroseptal side of the junction, between the right atrium and superior vena cava, facing the mid and caudal parts of the right superior pulmonary vein antrum on the right heart cavities on a CT image imported into the CARTO system. This map will be carefully merged with the CT image and the TL will be visible. No ablation is performed (sham). Pharmacological evaluation.

Trial Locations (3)

2820

RECRUITING

Imeldaziekenhuis, Bonheiden

3000

RECRUITING

Universitair Ziekenhuis Gasthuisberg, Leuven

8000

NOT_YET_RECRUITING

Algemeen Ziekenhuis Sint Jan, Bruges

All Listed Sponsors
collaborator

Universitaire Ziekenhuizen KU Leuven

OTHER

collaborator

AZ Sint-Jan AV

OTHER

collaborator

Biosense Webster, Inc.

INDUSTRY

collaborator

Trium Clinical Consulting

INDUSTRY

lead

Imelda Hospital, Bonheiden

OTHER

NCT04755101 - Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope | Biotech Hunter | Biotech Hunter