Management of Shock in Children With SAM or Severe Underweight and Diarrhea

PHASE3RecruitingINTERVENTIONAL
Enrollment

135

Participants

Timeline

Start Date

August 17, 2021

Primary Completion Date

July 31, 2025

Study Completion Date

November 30, 2025

Conditions
Shock HypovolemicShock, SepticBlood TransfusionAdrenalineDopamine
Interventions
DRUG

Blood and Dopamine

Children in this group will receive a transfusion of whole human blood in a dose of 10 mL/kg over 2-3 hours. They will also receive dopamine, 8 microgram/kg.min (increasing the dose after 15 minutes to 12 microgram/kg/min to a maximum of 15 microgram/kg/min)

DRUG

Blood and adrenaline

Children in this group will receive a transfusion of whole human blood in a dose of 10 mL/kg over 2-3 hours. They will also receive adrenaline, 0.1 microgram/kg/min (increasing the dose after 15 minutes to 0.2 microgram/kg.min to a maximum of 0.3 microgram/kg.min)

Trial Locations (1)

1000

RECRUITING

Icddr,B, Dhaka

All Listed Sponsors
collaborator

University of British Columbia

OTHER

collaborator

Muhimbili University of Health and Allied Sciences

OTHER

lead

International Centre for Diarrhoeal Disease Research, Bangladesh

OTHER