Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic Hepatitis B Virus (HBV) Infection

PHASE2CompletedINTERVENTIONAL
Enrollment

91

Participants

Timeline

Start Date

April 12, 2021

Primary Completion Date

July 4, 2023

Study Completion Date

July 4, 2023

Conditions
Hepatitis B, Chronic
Interventions
DRUG

BRII-835 (VIR-2218)

BRII-835 (VIR-2218) will be given by subcutaneous injection

BIOLOGICAL

BRII-179 (VBI-2601) with IFN-α

BRII-179 (VBI-2601) with IFN-α will be co-administered by intramuscular injection

BIOLOGICAL

BRII-179 (VBI-2601)

BRII-179 (VBI-2601) will be administered by intramuscular injection

Trial Locations (28)

500

Investigative Site 88602, Changhua, Taiwan

2025

Investigative Site 64001, Auckland

2145

Investigative Site 61001, Westmead

2747

Investigative Site 61002, Kingswood

3080

Investigative Site 82001, Seoul

3722

Investigative Site 82005, Seoul

4029

Investigative Site 61004, Herston

5505

Investigative Site 82002, Seoul

9016

Investigative Site 64002, Dunedin Central

10048

Investigative Site 88605, Taipei CITY

10330

Investigative Site 66001, Bangkok

11000

Investigative Site 66005, Nonthaburi

Investigative Site 66006, Nonthaburi

12120

Investigative Site 66004, Pathum Thani

13496

Investigative Site 82003, Seongnam-si, Gyeonggi-do

40002

Investigative Site 66002, Khon Kaen

40447

Investigative Site 88603, Taichung, Taiwan

49241

Investigative Site 82004, Busan

50200

Investigative Site 66003, Chiang Mai

83301

Investigative Site 88601, Kaohsiung, Taiwan

90110

Investigative Site 66007, Songkhla

169608

Investigative Site 65001, Singapore

529889

Investigative Site 65002, Singapore

Unknown

Investigative Site 85201, Hong Kong

Investigative Site 85202, Hong Kong

Investigative Site 85203, Hong Kong

Investigative Site 88604, Kaohsiung, Taiwan

Investigative Site 85204, NEW Territories, Hong Kong

Sponsors
All Listed Sponsors
collaborator

Vir Biotechnology, Inc.

INDUSTRY

collaborator

VBI Vaccines Inc.

INDUSTRY

lead

Brii Biosciences Limited

INDUSTRY

NCT04749368 - Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic Hepatitis B Virus (HBV) Infection | Biotech Hunter | Biotech Hunter