330
Participants
Start Date
March 31, 2021
Primary Completion Date
December 31, 2025
Study Completion Date
April 30, 2026
Antidepressant
"The antidepressant treatment utilizes antidepressant medication to improve pain, function, and depression outcomes.~The Antidepressant Treatment History Form (ATHF) will be used to assess adequacy of any prior antidepressant medication treatment and to assist the decision regarding which antidepressant to start. A medication flowchart will help serve as a guideline throughout the drug selection and dosing determination. Weekly assessments completed by subjects will help determine response, tolerability, and necessity for dose adjustment or medication change."
Enhanced Fear Avoidance Rehabilitation
The EFAR treatment utilizes physical therapy, pain education, and motivational messaging to improve pain, function, and depression outcomes. Subjects will engage in gradual exposure to exercises and activities they are apprehensive about, such as standing to wash dishes.
UPMC Pain Medicine At Centre Commons, Pittsburgh
Mayo Clinic, Rochester
BWH Pain Management Center, Chestnut Hill
Collaborators (1)
National Institutes of Health (NIH)
NIH
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Mayo Clinic
OTHER
Massachusetts General Hospital
OTHER
Ajay Wasan, MD, Msc
OTHER