Analyzing Pulsed Reduced Dose Radiotherapy in Upfront Glioblastoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

June 3, 2021

Primary Completion Date

March 5, 2025

Study Completion Date

September 30, 2027

Conditions
Glioblastoma
Interventions
DEVICE

Radiation

60 Gy to be delivered over 30 daily treatments in six weeks. Chemoradiation is to start no sooner than 3 weeks after surgery and not later than 8 weeks.

DRUG

Concurrent Chemotherapy (Temozolomide)

75mg/m\^2 x 42 days (concurrent chemotherapy with radiation). Chemoradiation is to start no sooner than 3 weeks after surgery and not later than 8 weeks.

DRUG

Adjuvant Chemotherapy (Temozolomide)

Starting no sooner than 4 weeks after completion of chemoradiation, 150-200mg/m\^2, days 1-5 of 28-day cycle, for minimum of six cycles and up to 12 cycles.

Trial Locations (1)

53226

Medical College of Wisconsin, Milwaukee

All Listed Sponsors
lead

Medical College of Wisconsin

OTHER