A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

662

Participants

Timeline

Start Date

June 8, 2021

Primary Completion Date

May 30, 2025

Study Completion Date

March 31, 2026

Conditions
Non-small Cell Lung CancerNSCLC
Interventions
DRUG

Tislelizumab

Tislelizumab is a monoclonal antibody formulated for intravenous injection.

DRUG

Ociperlimab

Ociperlimab is a monoclonal antibody formulated for intravenous injection.

DRUG

Pembrolizumab

Pembrolizumab is a monoclonal antibody formulated for intravenous injection.

DRUG

Placebo

Placebo infusions will consist of a sterile, normal saline solution.

Trial Locations (218)

640

National Taiwan University Hospital Yunlin Branch, Yunlin

1240

Baskent University Practice and Research Hospital Adana Medical Oncology Department, Adana

1409

Centro Medical Austral, Buenos Aires

2065

Northern Cancer Institute, St Leonards

2139

Concord Repatriation General Hospital, Concord

2298

Calvary Mater Newcastle, Waratah

3021

Western Health Sunshine Hospital, St Albans

3168

Monash Health, Clayton

3203

Hospital General Universitario de Elche, Elche

3350

Ballarat Health Services, Ballarat

4000

Centro Para La Atencion Del Paciente Oncologico (Caipo), San Miguel de Tucumán

4032

The Prince Charles Hospital, Chermside

4101

Mater Cancer Care Centre, South Brisbane

4217

Pindara Private Hospital, Benowa

4224

John Flynn Private Hospital, Tugun

5112

Lyell McEwin Hospital, Elizabeth Vale

6000

High Technology Hospital Medcenter Ltd, Batumi

6150

St John of God, Murdoch, Murdoch

6520

Memorial Ankara Hospital, Ankara

8028

Hospital Universitari Quiron Dexeus, Barcelona

10043

Aou San Luigi Gonzaga, Orbassano

10210

Chulabhorn Research Institute, Lak Si

10400

Phramongkutklao Hospital, Ratchathewi

Rajavithi Hospital, Ratchathewi

10700

Siriraj Hospital, Bangkok

11217

Taipei Veterans General Hospital, Taipei

13496

Cha Bundang Medical Center, Cha University, Gyeonggido

14647

The Catholic University of Korea Bucheon St Marys Hospital, Bucheon-si

15224

West Penn Hospital, Pittsburgh

16247

The Catholic University of Korea, St Vincents Hospital, Suwon

17007

Ico Girona, Girona

20251

Ambulantes Krebszentrum Hamburg, Hamburg

22030

Tr Trakya University Health Research and Application Center (Hospital), Edirne

22927

Lungenclinic Grosshansdorf Gmbh, Grohansdorf

23007

Hospital Universitario de Jaen, Jaén

24298

Icm Val Daurelle Oncologie Medicale, Montpellier

27003

Hospital Universitario Lucus Augusti, Lugo

27356

Agaplesion Diakonieklinikum Rotenburg Gemeinnutzige Gmbh, Rotenburg (Wümme)

28040

Hospital Clinico San Carlos, Madrid

Start Madrid Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario Doce de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28222

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

28644

Chungbuk National University Hospital, Cheongju-si

28922

Hospital Universitario Fundacion Alcorcon, Alcorcón

29010

Hospital Regional Universitario de Malaga, Málaga

Hospital Universitario Virgen de La Victoria, Málaga

30008

Hospital General Universitario Morales Meseguer, Murcia

32005

Complexo Hospitalario Universitario de Ourense, Ourense

32804

Advent Health Cancer Institute, Orlando

33076

Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux

33240

Mersin City Hospital, Mersin City Hospital

33305

Linkou Chang Gung Memorial Hospital, Taoyuan District

34098

Iu C, Clinical Research Excellence Application and Research Center, Istanbul

34474

Ocala Oncology Center Pl Dba Florida Cancer Affiliates Ocala, Ocala

34722

Tr Ministry of Health Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul

35016

Complejo Hospitalario Universitario Insular Gran Canaria, Las Palmas

35100

Ege University Medical Faculty, Izmir

35392

Uniklinikum Giessen Marburg, Giessen

37000

Chu Tours Hopital Bretonneau Service Pneumologie, Tours

40002

Srinagarind Hospital (Khon Kaen University), Muang

40138

Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi, Bologna

40201

Chung Shan Medical University Hospital, Taichung

40503

Baptist Health Lexington, Lexington

41013

Hospital Universitario Virgen Del Rocio, Seville

41014

Hospital Universitario Nuestra Senora de Valme, Seville

41380

Kocaeli Universitesi Tip Fakultesi, Kocaeli

41404

Kyungpook National University Chilgok Hospital, Daegu

42090

Necmettin Erbakan University Selcuklu Faculty of Medicine, Meram

42601

Keimyung University Dongsan Hospital, Dalseogu

44280

Inonu Universitesi Tip Fakultesi, Battalgazi

44805

Centre de Lutte Contre Le Cancer Institut de Cancerologie de Louest Rene Gauducheau, SaintHerblain

Chu Nantes Hopital Nord Laennec, SaintHerblain

46015

Hospital Arnau de Vilanova, Valencia

46026

Hospital Universitari I Politecnic La Fe, Valencia

46526

Goshen Center For Cancer Care, Goshen

50000

Medical Center of Limited Liability Company Mriya Med Service, Kryvyi Rih

50006

Changhua Christian Hospital, Changhua

50200

Maharaj Nakorn Chiang Mai Hospital (Chiang Mai University), Muang

51109

Kliniken Der Stadt Koeln Ggmbh, Cologne

52074

Universitaetsklinikum Aachen, Aachen

53127

Universitatsklinikum Bonn, Bonn

54100

Polyclinique de Gentilly, Nancy

55101

Metro Minnesota Community Oncology Research Consortium (Mmcorc), Saint Paul

64100

Centre Hospitalier de La Cote Basque Saint Leon Service de Pneumologie, Bayonne

69317

Hopital de La Croix Rousse, Lyon

69495

Chu Hopital Lyon Sud, PierreBenite

69500

Hopital Louis Pradel, Lyon

70112

University Medical Center New Orleans West Jefferson Medical Center, New Orleans

75014

Hopital Cochin, Paris

81925

Munchen Klinik Bogenhausen, Munich

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

88000

Communal Non Profit Enterprisecentral Municipal Clinical Hospital of Uzhhorod City Council, Uzhhorod

88011

Zakarpatska Regional Clinical Oncological Center, Uzhhorod

90067

Valkyrie Clinical Trials, Los Angeles

90110

Songklanagarind Hospital (Prince of Songkhla University), Hat Yai

92835

Providence Medical Foundation St Jude Heritage Healthcare, Fullerton

94160

Hia Begin, Saint-Mandé

97448

Chu de La Reunion, Saint-Pierre

98158

Azienda Ospedaliera Papardo, Messina

100020

Beijing Chao Yang Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

100730

Peking Union Medical College Hospital, Beijing

101149

Beijing Chest Hospital, Capital Medical University, Beijing

110042

Liaoning Cancer Hospital and Institute, Shenyang

121309

Vitamed Llc, Moscow

150000

Harbin Medical University Cancer Hospital, Harbin

163045

Arkhangelsk Regional Clinical Oncological Dispensary, Arkhangelsk

197082

Llc Av Medical Group, Saint Petersburg

200030

Shanghai Chest Hospital, Shanghai

200032

Affiliated Zhongshan Hospital of Fudan University, Shanghai

200433

Shanghai Pulmonary Hospital, Shanghai

210009

Nanjing First Hospital, Nanjing

210029

Nanjing Chest Hospital, Nanjing

213003

Changzhou No Peoples Hospital, the Affiliated Hospital of Nanjing Medical University Branch Cheng, Changzhou

215000

The Second Affiliated Hospital of Soochow University, Suzhou

215006

The First Affiliated Hospital of Soochow University Branch Shizi, Suzhou

221000

Xuzhou Central Hospital, Xuzhou

230000

Anhui Provincial Hospital, Hefei

230601

The Second Hospital of Anhui Medical University, Hefei

231405

Taipei Tzu Chi Hospital, Taipei

261000

Weifang Peoples Hospital, Weifang

264000

Yantai Yuhuangding Hospital, Yantai

266000

The Affiliated Hospital of Qingdao University Branch Laoshan, Qingdao

300052

Tianjin Medical University General Hospital, Tianjin

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310016

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

315010

The First Affiliated Hospital of Ningbo University, Ningbo

317000

Taizhou Hospital of Zhejiang, Taizhou

322000

The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu

350001

Fujian Medical University Union Hospital, Fuzhou

350014

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

400030

Chongqing Cancer Hospital, Chongqing

400038

The First Affiliated Hospital of Army Military Medical University, Chongqing

400042

Daping Hospital, Third Military Medical University, Chongqing

404000

Chongqing University Three Gorges Central Hospital, Chongqing

410011

The Second Xiangya Hospital of Central South University, Changsha

410013

Hunan Cancer Hospital, Changsha

430022

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430060

Renmin Hospital of Wuhan University, Wuhan

430079

Hubei Cancer Hospital, Wuhan

443031

State Budgetary Healthcare Institution Samara Regional Clinical Oncology Dispensary, Samara

450000

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

450054

State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the Republic, Ufa

455001

State Budgetary Healthcare Institution Regional Oncology Dispensary Number, Magnitogorsk

510030

Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou

515031

Cancer Hospital of Shantou University Medical College, Shantou

518020

Shenzhen Peoples Hospital, Shenzhen

530021

The Peoples Hospital of Guangxi Zhuang Autonomous Region, Nanning

The Tumor Hospital Affiliated to Guangxi Medical University, Nanning

603081

State Budgetary Healthcare Institution Nizhny Novgorod Regional Clinical Oncology Dispensary, Nizhny Novgorod

610041

Sichuan Cancer Hospital and Institute, Chengdu

West China Hospital, Sichuan University, Chengdu

637000

Affiliated Hospital of North Sichuan Medical College, Nanchong

644013

Bih of Omsk Region Clinical Oncology Dispensary, Omsk

710061

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

830000

Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

70390140

Instituto Dor de Pesquisa E Ensino Distrito Federal, Brasília

29308-020

Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim

88034-000

Centro de Pesquisas Oncologicas Cepon, Florianópolis

60430-235

Cancer Institute of Ceara, Fortaleza

09060-650

Cepho Centro de Estudos E Pesquisas de Hematologia E Oncologia, Santo André

15090-000

Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, São José do Rio Preto

030032

Shanxi Bethune Hospital, Taiyuan

0112

Acad Fridon Todua Medical Center Ltd Research Institute of Clinical Medicine Ltd, Tbilisi

Israel Georgian Medical Research Clinic Helsicore Ltd, Tbilisi

0119

Jsc German Hospital, Tbilisi

0159

Institute of Clinical Oncology Ltd, Tbilisi

Jsc Evex Hospitals Tbilisi, Tbilisi

0160

Tim Tbilisi Institute of Medicine Ltd, Tbilisi

0186

Caucasus Medical Centre Ltd, Tbilisi

Multiprofile Clinic Consilium Medulla Ltd, Tbilisi

Oncology Research Center Ltd, Tbilisi

466-8560

Nagoya University Hospital, Nagoya

036-8563

Hirosaki University Hospital, Hirosaki

791-0280

Nho Shikoku Cancer Center, Matsuyama

830-0011

Kurume University Hospital, Kurume

337-0280

National Hospital Organization Shibukawa Medical Center, Shibukawa

650-0017

Kobe University Hospital, Kobe

650-0047

Kobe City Medical Center General Hospital, Kobe

663-8501

Hyogo Medical University Hospital, Nishinomiyashi

920-8641

Kanazawa University Hospital, Kanazawa

241-8515

Kanagawa Cancer Center, Yokohama

981-1293

Miyagi Cancer Center, Natorishi

700-8558

Okayama University Hospital, Okayama

573-1191

Kansai Medical University Hospital, Hirakata

591-8555

National Hospital Organization Kinki Chuo Chest Medical Center, Sakai

589-8511

Kindai University Hospital, Sayama

560-8552

Osaka Toneyama Medical Center, Toyonaka

329-0498

Jichi Medical University Hospital, Shimonotsuke

321-0293

Dokkyo Medical University Hospital, Shimotsugagun

320-0834

Tochigi Cancer Center, Utsunomiya

113-8603

Nippon Medical School Hospital, Bunkyoku

135-8550

Cancer Institute Hospital of Jfcr, Kotoku

734-8551

Hiroshima University Hospital, Hiroshima

951-8566

Niigata Cancer Center Hospital, Niigata

3813 TZ

Meander Medisch Centrum, Amersfoort

6815 AD

Rijnstate, Arnhem

3844 DG

Ziekenhuis St Jansdal, Harderwijk

6419 PC

Stichting Zuyderland Medisch Centrum, Heerlen

8025 AB

Isala Klinieken Zwolle, Zwolle

15-276

Uniwersytecki Szpital Kliniczny W Bialymstoku, Bialystok

90-338

Centrum Terapii Wspoczesnej, Lodz

93-510

Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz

60-569

Wielkopolskie Centrum Pulmonologii I Torakochirurgii, Poznan

60-693

Przychodnia Med Polonia Sp Z Oo, Poznan

22-400

Etg Zamosc, Zamość

03312

The Catholic University of Korea, Eunpyeong St Marys Hospital, Eunpyeonggu

03722

Severance Hospital Yonsei University Health System, Seoul

08003

Hospital Del Mar, Barcelona

08025

Hospital de La Santa Creu I Sant Pau, Barcelona

08035

Hospital Universitario Vall Dhebron, Barcelona

07120

Hospital Universitari Son Espases, Palma de Mallorca

01130

Acibadem Adana Hospital, Adana

06200

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY