Neurological and Neuropsychological Sequelae of COVID-19 Infection

CompletedOBSERVATIONAL
Enrollment

329

Participants

Timeline

Start Date

December 12, 2020

Primary Completion Date

February 21, 2022

Study Completion Date

February 21, 2022

Conditions
COVID-19 Infection
Interventions
DIAGNOSTIC_TEST

MRI

3T cranial MRI with T1-, and T2 weighted imaging, a FLAIR sequence, diffusion-weighted imaging and susceptibility-weighted sequence

DIAGNOSTIC_TEST

Neuropsychological assessment

Montreal Cognitive Assessment (MoCA), Rey-Auditory Verbal Learning Test (RAVLT), Trail making A/B, Stroop, Digit Span Coding, Judgement of line orientation (JOLO), Boston Naming Task (BNT), Controlled Oral Word Associations Task (COWAT), Category Fuency, Test of Memory Malingering (TOMM)

DIAGNOSTIC_TEST

Questionnaires Patient

EuroQol-5D-5L (EQ-5D-5L), Utrecht Scale for Evaluation of Rehabilitation-Participation - Restrictions (USER-P-R), NeNeSCo-Q (questionnaire created for this study, including common neurological symptoms), Checklist for post-IC cognitive complaints (CLC-IC self-report), Hospital Anxiety and Depression Scale (HADS), Primary Care Post-Traumatic Stress Disorder (PC-PTSD-5), Utrecht Coping List (UCL) (subscale passive coping), PROMIS physical functioning short form, Items of Insomnia Severity Index (ISI) \& Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Social Support List (SSL-12-I)

DIAGNOSTIC_TEST

Questionnaires Family

EuroQol-5D-5L (EQ-5D-5L), Utrecht Scale for Evaluation of Rehabilitation-Participation - Restrictions (USER-P-R), Checklist for post-IC cognitive complaints (CLC-IC proxy-report), Hospital Anxiety and Depression Scale (HADS), Primary Care Post-Traumatic Stress Disorder (PC-PTSD-5), Utrecht Coping List (UCL) (subscale passive coping), Social Support List (SSL-12-I), Caregiver Strain Index (CSI)

Trial Locations (3)

6229 ER

Maastricht University, Maastricht

Unknown

Amsterdam Universitair Medische Centra, Amsterdam

Universitair Medische Centra Utrecht, Utrecht

All Listed Sponsors
collaborator

Netherlands Brain Foundation

OTHER

collaborator

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

collaborator

UMC Utrecht

OTHER

lead

Maastricht University

OTHER

NCT04745611 - Neurological and Neuropsychological Sequelae of COVID-19 Infection | Biotech Hunter | Biotech Hunter