Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

122

Participants

Timeline

Start Date

March 5, 2021

Primary Completion Date

November 1, 2022

Study Completion Date

October 8, 2024

Conditions
Advanced Colorectal Cancer
Interventions
DRUG

DS-8201a 5.4 mg/kg Q3W

DS-8201a for injection will be administered intravenously (IV) at a dose of 5.4 mg/kg every 3 weeks (Q3W)

DRUG

DS-8201a 6.4 mg/kg Q3W

DS-8201a for injection will be administered intravenously (IV) at a dose of 6.4 mg/kg every 3 weeks (Q3W)

Trial Locations (63)

10065

Memorial Sloan Kettering Cancer Center (MSKCC), New York

27710

Duke University Medical Center, Durham

37203

Sarah Cannon (Tennessee Oncology - Nashville), Nashville

40217

Norton Cancer Institute Audubon, Louisville

48109

University of Michigan Health System, Ann Arbor

60637

The University of Chicago, Chicago

77030

The University of Texas MD Anderson Cancer Center, Houston

02114

Massachusetts General Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

Unknown

Flinders Medical Centre (FMC), Bedford Park

Blacktown Hospital, Blacktown

Royal Brisbane & Women's Hospital, Brisbane

Monash Medical Centre, Clayton

Peter MacCallum Cancer Centre, Melbourne

UCL St-Luc, Brussels

UZ Antwerpen, Edegem

Universitair Ziekenhuis Gent, Ghent

Hopital Jean Minjoz, Besançon

Hopital Edouard Herriot, Lyon

ICM-Val d'Aurelle, Montpellier

University Hospital of nantes, Nantes

Centre Antoine Lacassagne, Nice

Hopital St Antoine, Paris

Centre de Lutte Contre le Cancer CLCC - Institut Curie, Saint-Cloud

Chu Toulouse, Toulouse

Asst Grande Ospedale Metropolitano Niguarda, Milan

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

Istituto Oncologico Veneto Irccs, Padua

Azienda Ospedaliero Universitaria Pisana, Pisa

Aienda Ospedaliera San Camillo Forlanini, Rome

Azienda ULSS 8 Berica, Vicenza

Aichi Cancer Center Hospital, Aichi

National Cancer Center Hospital East, Chiba

National Hospital Organization Shikoku Cancer Center, Ehime

National Hospital Organization Kyushu Cancer Center, Fukuoka

Hokkaido University Hospital, Hokkaido

Kanagawa Cancer Center, Kanagawa

Kindai University Hospital, Osaka

National Hospital Organization Osaka National Hospital, Osaka

National Cancer Center Hospital, Tokyo

The Cancer Institute Hospital of JFCR, Tokyo

National Cancer Center (NCC), Goyang-si

Seoul National University Bundang Hospital, Gyeonggi-do

Asan Medical Center, Seoul

Samsung Medical Center, Seoul

Seoul National University Hospital, Seoul

Severance Hospital Yonsei University Health System, Seoul

Hospital Clinico y Provincial de Barcelona, Barcelona

Hospital Universitari Vall dHebron, Barcelona

Clinica Universitaria de Navarra - Madrid, Madrid

Hospital Universitario 12 de Octubre, Madrid

Clinica Universitaria de Navarra, Pamplona

Kaohsiung Medical University Chung-Ho Memorial Hospital KMUH, Kaohsiung City

China Medical University Hospital, Taichung

National Cheng Kung University Hospital, Tainan City

National Taiwan University Hospital, Taipei

Chang Gung Memorial Hospital CGMH - Kaohsiung Branch, Taoyuan District

Chang Gung Memorial Hospital-LinKou, Taoyuan District

Beatson Glasgow, Glasgow

The Royal Marsden Hospital, London

UCLH Trust, London

The Christie, Manchester

The Royal Marsden Hospital, Sutton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY