A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,653

Participants

Timeline

Start Date

April 14, 2021

Primary Completion Date

October 29, 2026

Study Completion Date

October 29, 2026

Conditions
Carcinoma, Renal Cell
Interventions
BIOLOGICAL

Pembrolizumab

Pembrolizumab 400 mg administered Q6W via IV infusion

DRUG

Belzutifan

Belzutifan 120 mg administered QD via oral tablet

BIOLOGICAL

Pembrolizumab/Quavonlimab

Pembrolizumab/quavonlimab is a co-formulated product composed of pembrolizumab 400 mg in combination with quavonlimab 25 mg, administered Q6W via IV infusion

DRUG

Lenvatinib

Lenvatinib 20 mg administered QD via oral capsule

Trial Locations (262)

100

National Taiwan University Hospital ( Site 4401), Taipei

333

Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 4406), Taoyuan District

704

National Cheng Kung University Hospital ( Site 4404), Tainan City

833

Chang Gung Medical Foundation. Kaohsiung Branch ( Site 4405), Kaohsiung City

1000

Manila Doctors Hospital ( Site 4601), Manila

1122

Orszagos Onkologiai Intezet ( Site 2304), Budapest

1478

Akershus universitetssykehus ( Site 2000), Lorenskog

1502

Cardinal Santos Medical Center ( Site 4603), San Juan City

1605

The Medical City ( Site 4602), Pasig

1714

Sykehuset Østfold HF Kalnes ( Site 2003), Grålum

1939

Vaal Triangle Oncology Centre ( Site 3010), Vereeniging

2109

Macquarie University ( Site 4007), Macquarie University

2170

Liverpool Hospital ( Site 4006), Liverpool

2193

Wits Clinical Research ( Site 3012), Johannesburg

2196

Sandton Oncology Medical Group PTY LTD ( Site 3000), Johannesburg

2730

Herlev Hospital ( Site 1700), Herlev

3168

Monash Health ( Site 4008), Clayton

4032

Debreceni Egyetem Klinikai Kozpont ( Site 2301), Debrecen

4615

Soerlandet sykehus HF Kristiansand ( Site 2007), Kristiansand

5000

Odense University Hospital ( Site 1701), Odense

5004

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 2300), Szolnok

5021

Helse Bergen HF - Haukeland Universitetssykehus ( Site 2002), Bergen

5112

Lyell McEwin Hospital ( Site 4004), Elizabeth Vale

5700

Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 2309), Gyula

6000

Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2308), Kecskemét

6045

Cancer Care Langenhoven Drive Oncology Centre ( Site 3009), Port Elizabeth

6150

Fiona Stanley Hospital ( Site 4009), Murdock

7030

St. Olavs Hospital HF ( Site 2005), Trondheim

7570

Cape Town Oncology Trials Pty Ltd ( Site 3006), Kraaifontein

7700

Cancercare Rondebosch Oncology ( Site 3005), Rondebosch

7925

Groote Schuur Hospital ( Site 3011), Cape Town

9700

Markusovszky Egyetemi Oktatokorhaz ( Site 2303), Szombathely

10000

Klinicki Bolnicki Centar Zagreb ( Site 3200), Zagreb

"Klinicki bolnicki centar Sestre milosrdnice ( Site 3201)", Zagreb

10065

Sidney Kimmel Center for Prostate and Urologic Cancers ( Site 0055), New York

10117

Charite Universitaetsmedizin Berlin ( Site 1301), Berlin

10400

Ramathibodi Hospital. ( Site 4500), Bangkok

10408

National Cancer Center ( Site 4202), Goyang-si

10700

Siriraj Hospital ( Site 4501), Bangkok

11042

R.J. Zuckerberg Cancer Center-Medical Oncology ( Site 0013), Lake Success

11217

Taipei Veterans General Hospital ( Site 4402), Taipei

13009

Institut Paoli Calmettes ( Site 1206), Marseille

14029

Chernihiv Medical Center of Modern Oncology ( Site 2709), Chernihiv

14080

Instituto Nacional de Cancerologia ( Site 0602), Mexico City

14203

Roswell Park Cancer Institute ( Site 0032), Buffalo

17007

Institut Català d'Oncologia (ICO) - Girona ( Site 1500), Girona

18000

Klinicki centar Nis ( Site 3322), Niš

18009

Cherkasy Regional Oncology Dispensary ( Site 2704), Cherkasy

19049

Helios Kliniken Schwerin GmbH ( Site 1302), Schwerin

20132

Ospedale San Raffaele-Oncologia Medica ( Site 1417), Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1409), Milan

20520

TYKS ( Site 1802), Turku

21000

Klinički Bolnički Centar Split ( Site 3202), Split

21204

Institut za onkologiju Vojvodine ( Site 3311), Kamenitz

22030

Trakya University Medical Faculty Balkan Oncology Hospital ( Site 2906), Edirne

25000

CHU Jean Minjoz ( Site 1205), Besançon

28040

Hospital Clinico San Carlos ( Site 1503), Madrid

28041

Hospital Universitario 12 de Octubre ( Site 1505), Madrid

29016

Hospital Universitario Virgen de la Victoria ( Site 1504), Málaga

29401

Ralph H. Johnson VA Center ( Site 0073), Charleston

30322

Emory University Winship Cancer Institute ( Site 0012), Atlanta

30607

University Cancer & Blood Center, LLC ( Site 0057), Athens

31059

Institut Claudius Regaud ( Site 1214), Toulouse

32804

Advent Health Hematology & Oncology ( Site 0003), Orlando

33520

TAYS ( Site 1801), Tampere

34098

Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2900), Istanbul

34722

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2901), Istanbul

35015

Chungnam National University Hospital ( Site 4205), Daejeon

35040

Ege Universitesi Tip Fakultesi Hastanesi ( Site 2904), Izmir

35340

Dokuz Eylul Universitesi Tip Fakultesi Hastanesi ( Site 2905), Izmir

37232

Vanderbilt University Medical Center ( Site 0069), Nashville

37920

University of Tennessee Medical Center Knoxville ( Site 0019), Knoxville

39008

Hospital Universitario Marques de Valdecilla ( Site 1501), Santander

39216

University of Mississippi Medical Center ( Site 0037), Jackson

40207

Norton Cancer Institute - St. Matthews ( Site 0065), Louisville

40705

Taichung Veterans General Hospital ( Site 4403), Taichung

41100

Azienda Ospedaliero - Universitaria Policlinico di Modena ( Site 1404), Modena

44280

Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0610), Guadalajara

46845

Parkview Cancer Institute ( Site 0088), Fort Wayne

48202

Henry Ford Hospital ( Site 0038), Detroit

49005

ME І.І. Mechnykov Dnipro Regional Clinical Hospital ( Site 2710), Dnipropetrovsk

49055

Clinical oncology dispensary of Dnipro ( Site 2700), Dnipro

49503

Cancer & Hematology Centers of Western Michigan ( Site 0018), Grand Rapids

49933

CHU Angers ( Site 1200), Angers

50586

Hospital Kuala Lumpur ( Site 4301), Kuala Lumpur

55101

Regions Hospital ( Site 0095), Saint Paul

55426

HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0005), Saint Louis Park

59100

Universiti Malaya Medical Centre ( Site 4300), Kuala Lumpur

60607

Rush University Medical Center ( Site 0040), Chicago

61000

Regional Oncology Center of Kharkiv ( Site 2708), Kharkiv

61037

Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 2715), Kharkiv

62250

Institut Kanser Negara - National Cancer Institute ( Site 4302), Putrajaya

62660

Clinique Ambroise Pare Beuvry ( Site 1213), Beuvry

64710

I CAN Oncology SA de SV ( Site 0601), Monterrey

68017

Fundacion Cardiovascular de Colombia ( Site 0506), Piedecuesta

68020

Centro de Investigacion Clinica de Oaxaca ( Site 0605), Oaxaca City

69310

CH Lyon Sud Hospices Civils de Lyon ( Site 1203), Pierre-Bénite

70121

Ochsner Medical Center ( Site 0049), New Orleans

70124

Azienda Ospedaliera Policlinico di Bari ( Site 1411), Bari

70210

Kuopion Yliopistollinen Sairaala ( Site 1803), Kuopio

72076

Universitaetsklinik fuer Urologie ( Site 1300), Tübingen

75020

Hopital Tenon ( Site 1212), Paris

75390

UTSW Medical Center ( Site 0015), Dallas

76000

Hospital H+ Queretaro-Cuidados Oncológicos ( Site 0608), Querétaro City

76008

Ivano-Frankivsk Regional Hospital-Urology department ( Site 2707), Ivano-Frankivsk

76018

Ivano-Frankivsk Regional Oncology Clinical Dispensary ( Site 2711), Ivano-Frankivsk

77900

Fakultni nemocnice Olomouc ( Site 2200), Olomouc

79031

Lviv State Regional Oncological Center ( Site 2712), Lviv

80131

Istituto Nazionale Tumori Fondazione Pascale ( Site 1412), Napoli

81100

Hospital Sultan Ismail ( Site 4303), Johor Bahru

85796

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2420), Bydgoszcz

87039

Clinique Francois Chenieux ( Site 1209), Limoges

90048

Cedars Sinai Medical Center ( Site 0027), Los Angeles

90404

UCLA Hematology Oncology Santa Monica ( Site 0048), Santa Monica

92037

UC San Diego ( Site 0050), La Jolla

92868

University of California Irvine ( Site 0029), Orange

94800

Gustave Roussy ( Site 1207), Villejuif

97239

Oregon Health & Science University ( Site 0071), Portland

98801

Central Washington Health Services Association d/b/a Confluence Health ( Site 0061), Wenatchee

100021

Cancer Hospital Chinese Academy of Medical Science-Oncology ( Site 6026), Beijing

100034

Peking University First Hospital ( Site 6011), Beijing

100142

Beijing Cancer hospital-Renal carcinoma and melanoma ( Site 6000), Beijing

110221

Administradora Country SA - Clinica del Country ( Site 0504), Bogotá

110411

Instituto Nacional de Cancerología E.S.E. ( Site 0503), Bogotá

111123

The Loginov Moscow Clinical Scientific Center ( Site 2604), Moscow

112106

Klinicki centar Srbije. ( Site 3333), Belgrade

129090

Moscow Oncological Clinical Dispensary #1 ( Site 2619), Moscow

150081

Harbin Medical University Cancer Hospital-urology ( Site 6015), Harbin

153040

Ivanovo Regional Oncology Dispensary ( Site 2615), Ivanovo

197758

Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2617), Saint Petersburg

198255

City clinical oncological dispensary ( Site 2605), Saint Petersburg

200001

Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 6017), Shanghai

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0505), Valledupar

200072

Shanghai Tenth People's Hospital ( Site 6023), Shanghai

200746

S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2501), Craiova

210000

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( S, Nanjing

215004

The Second Affiliated Hospital of Soochow University-Urology ( Site 6025), Suzhou

233004

The First Afflilated Hospital of Bengbu Medical College-Urology Surgery ( Site 6041), Bengbu

300060

Tianjin Medical University Cancer Institute and Hospital ( Site 6029), Tianjin

300211

The Second Hospital of Tianjin Medical University ( Site 6032), Tianjin

300239

Policlinica Oncomed SRL ( Site 2506), Timișoara

310003

The First Affiliated Hospital, Zhejiang University ( Site 6024), Hangzhou

314001

The First Hospital of Jiaxing ( Site 6033), Jiaxing

315010

Ningbo First Hospital-Urology ( Site 6028), Ningbo

325000

The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 6021), Wenzhou

330006

The First Affiliated Hospital of Nanchang University ( Site 6019), Nanchang

330029

Jiangxi Provincial Cancer Hospital ( Site 6042), Nanchang

350005

The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 6038), Fuzhou

361003

The First Affiliated hospital of Xiamen University-Urology ( Site 6001), Xiamen

400030

Chongqing University Cancer Hospital ( Site 6009), Chongqing

410000

Xiangya Hospital Central South University ( Site 6034), Changsha

410013

Hunan Cancer Hospital ( Site 6020), Changsha

430022

Wuhan Union Hospital ( Site 6002), Wuhan

450008

Henan Cancer Hospital-Urology ( Site 6006), Zhengzhou

510007

Spitalul Judetean de Urgenta Alba Iulia ( Site 2502), Alba Iulia

510060

SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 6003), Guangzhou

510120

The First Affiliated Hospital of Guangzhou Medical University-Urology ( Site 6036), Guangzhou

510180

Guangzhou First People's Hospital ( Site 6007), Guangzhou

510289

Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Urology Surgery ( Site 6005), Guangzhou

603074

FBHI Privolzhsky District Medical Center of the FMBA ( Site 2611), Nizhny Novgorod

603081

Nizhniy Novgorod Region Oncology Dispensary ( Site 2621), Nizhny Novgorod

610041

West China Hospital Sichuan University-Urology Surgery ( Site 6016), Chengdu

656045

Altay Regional Oncology Dispensary ( Site 2610), Barnaul

660001

Oncólogos del Occidente S.A ( Site 0501), Pereira

660133

Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 2609), Krasnoyarsk

710061

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 6014), Xi'an

1720430

IC La Serena Research ( Site 0403), La Serena

2852424

Servicios Medicos Urumed ( Site 0405), Rancagua

4800827

Centro Investigacion Cancer James Lind ( Site 0402), Temuco

7500921

Fundacion Arturo Lopez Perez ( Site 0400), Santiago

8420383

Bradfordhill-Clinical Area ( Site 0401), Santiago

30130090

Centro Avançado de Tratamento Oncológico- CENATRON-Clinical Research ( Site 0303), Belo Horizonte

35294-3300

The University of Alabama at Birmingham ( Site 0010), Birmingham

06102

Hartford Hospital ( Site 0024), Hartford

04074

New England Cancer Specialists ( Site 0082), Scarborough

02114

Massachusetts General Hospital ( Site 0094), Boston

02215

Beth Israel Deaconess Medical Center ( Site 0089), Boston

Dana Farber Cancer Institute ( Site 0093), Boston

01805

Lahey Hospital & Medical Center ( Site 0090), Burlington

03756

Dartmouth Hitchcock Medical Center ( Site 0075), Lebanon

60135-237

Oncocentro Ceara ( Site 0309), Fortaleza

29308-014

Centro de Pesquisas Clinicas em Oncologia ( Site 0306), Cachoeiro de Itapemirim

59075-740

Liga Norte Riograndense Contra o Cancer ( Site 0308), Natal

90035-903

Hospital de Clinicas de Porto Alegre ( Site 0310), Porto Alegre

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0302), São Paulo

01321-001

BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0300), São Paulo

01525-001

A.C. Camargo Cancer Center ( Site 0301), São Paulo

T4N 4N2

Tom Baker Cancer Centre ( Site 0119), Calgary

V5Z 4E6

BC Cancer - Vancouver Center ( Site 0120), Vancouver

L8V 5C2

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0117), Hamilton

M4N 3M5

Sunnybrook Research Institute ( Site 0116), Toronto

G1J 1Z4

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0, Québec

050024

Instituto de Cancerología S.A Clínica de las Americas (ICCLA) ( Site 0500), Medellín

080020

Clinica de la Costa S.A.S. ( Site 0502), Barranquilla

656 53

Masarykuv onkologicky ustav ( Site 2203), Brno

741 01

Nemocnice AGEL Novy Jicin a.s. ( Site 2202), Nový Jičín

708 52

Fakultni nemocnice Ostrava ( Site 2208), Ostrava

656 91

Fakultni nemocnice u sv. Anny v Brne ( Site 2205), Brno

140 59

Fakultni Thomayerova nemocnice ( Site 2201), Prague

150 06

2 LF UK a FN Motol ( Site 2207), Prague

00290

HYKS ( Site 1800), Helsinki

09002

Centro Medico Integral de Cancerologia CEMIC ( Site 0701), Salcajá

01010

Oncomedica ( Site 0700), Guatemala City

01015

Grupo Angeles SA ( Site 0705), Guatemala City

Sanatorio Nuestra Senora del Pilar ( Site 0702), Guatemala City

01016

Medi-K Cayala ( Site 0703), Guatemala City

09001

Centro Regional de Sub Especialidades Medicas SA ( Site 0704), Quetzaltenango

D09 V2N0

Beaumont Hospital ( Site 6101), Dublin

D24 NR0A

Tallaght University Hospital ( Site 6100), Dublin

00168

Fondazione Policlinico Universitario A. Gemelli ( Site 1414), Rome

05100

Azienda Ospedaliera S. Maria di Terni ( Site 1410), Terni

470-1192

Fujita Health University ( Site 5003), Toyoake

260-8717

Chiba cancer center ( Site 5021), Chiba

277-8577

National Cancer Center Hospital East ( Site 5000), Kashiwa

791-0295

Ehime University Hospital ( Site 5020), Tōon

060-8543

Sapporo Medical University Hospital ( Site 5008), Sapporo

060-8648

Hokkaido University Hospital ( Site 5013), Sapporo

241-8515

Kanagawa cancer center ( Site 5016), Yokohama

634-0813

Nara Medical University Hospital ( Site 5002), Kashihara

589-8511

Kindai University Hospital- Osakasayama Campus-Urology ( Site 5010), Sayama

565-0871

Osaka University Hospital ( Site 5012), Suita

350-1298

Saitama Medical University International Medical Center ( Site 5015), Hidaka

431-3192

Hamamatsu University School of Medicine University Hospital ( Site 5004), Hamamatsu

113-8519

Tokyo Medical And Dental University Medical Hospital-Urology ( Site 5009), Bunkyō

105-8470

Toranomon Hospital ( Site 5001), Minato-ku

930-0194

Toyama University Hospital ( Site 5014), Toyoma

812-8582

Kyushu University Hospital ( Site 5005), Fukuoka

860-8556

Kumamoto University ( Site 5022), Kumamoto

951-8520

Niigata University Medical & Dental Hospital ( Site 5024), Niigata

700-8558

Okayama University Hospital ( Site 5017), Okayama

770-8503

Tokushima University Hospital-Department of Urology ( Site 5019), Tokushima

113-8603

Nippon Medical School Hospital ( Site 5006), Tokyo

123-8558

Tokyo Women's Medical University Adachi Medical Center ( Site 5023), Tokyo

160-8582

Keio university hospital ( Site 5011), Tokyo

0379

Oslo Universitetssykehus Radiumhospitalet ( Site 2001), Oslo

62-500

Przychodnia Lekarska KOMED ( Site 2419), Konin

60-569

Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2406), Poznan

26-600

Radomskie Centrum Onkologii ( Site 2418), Radom

01-748

Luxmed Onkologia sp. z o. o. ( Site 2412), Warsaw

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2405), Warsaw

75-581

Szpital Wojewodzki im. Mikolaja Kopernika ( Site 2407), Koszalin

022548

S.C.Focus Lab Plus S.R.L ( Site 2503), Bucharest

0002

Univ. Pretoria and Steve Biko Academic Hospitals ( Site 3002), Pretoria

0040

Life Wilgers Hospital ( Site 3004), Pretoria

0181

Mary Potter Oncology Centre, Little Company of Mary Hospital ( Site 3001), Pretoria

02841

Korea University Anam Hospital ( Site 4206), Seoul

03080

Seoul National University Hospital ( Site 4201), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 4204), Seoul

05505

Asan Medical Center ( Site 4203), Seoul

06351

Samsung Medical Center ( Site 4200), Seoul

08908

Instituto Catalan de Oncologia - ICO ( Site 1502), L'Hospitalet de Llobregat

551 85

Lanssjukhuset Ryhov ( Site 2103), Jönköping

171 76

Karolinska Universitetssjukhuset Solna ( Site 2100), Stockholm

751 85

Akademiska Sjukhuset ( Site 2105), Uppsala

901 85

Norrlands Universitetssjukhus ( Site 2106), Umeå

413 45

Sahlgrenska Universitetssjukhuset ( Site 2102), Gothenburg

06100

Ankara Universitesi Tip Fakultesi ( Site 2902), Ankara

Hacettepe Universitesi Tıp Fakultesi ( Site 2903), Ankara

03115

Kyiv City Clinical Oncology Center ( Site 2706), Kyiv

CB2 2QQ

Addenbrookes Hospital ( Site 3110), Cambridge

EC1A 7BE

Barts Health NHS Trust - St Bartholomew s Hospital ( Site 3116), London

HA6 2RN

Mount Vernon Cancer Centre ( Site 3101), Northwood

All Listed Sponsors
collaborator

Eisai Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY