Investigating Inhibitory Control Networks in Parkinson's Disease

NARecruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

April 1, 2021

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2028

Conditions
Parkinson Disease
Interventions
OTHER

Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease

After creation of the burr hole and prior to DBS electrode placement, 1-2 subdural strip electrodes will be placed anteriorly or posteriorly from the cranial opening. These electrodes are routinely placed using this technique for seizure mapping, with arrays of electrodes (up to 6) being placed around the perimeter of the opening.14 Subdural strips vary in length and contact size (e.g., the 6-contact Ad-Tech strip), and are currently placed predominantly for studies of sensorimotor function,13 including at our institution (IRB-140327003). Placement over prefrontal areas is performed at other institutions.11-13 The DBS surgery will then proceed according to routine practice, and following lead placement in the optimal desired location, the research task paradigm will begin.

Trial Locations (1)

35233

RECRUITING

University of Alabama at Birmingham, Birmingham

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

University of Alabama at Birmingham

OTHER