Study of Parameters of Osteosarcopenia in Patients With Hip Fracture

Assessment of muscle performance based on self-reported information about grip strength, assistance with walking, rising from a chair, climbing stairs, and falls.

Assessment of histomorphology and matrix-structure of tissue samples obtained from the bone resected during the hip prosthesis positioning.

Assessment of histomorphology and ultrastructure of muscle biopsies taken from the upper portion of the vastus lateralis muscle, which is accessed in the surgical procedure of hip replacement.

Quantification of circulating myostatin, a muscle-specific biomarker that suppresses muscle growth and bone formation.

Quantification of circulating IGF-1, a growth factor that promotes muscle growth and osteogenesis.

Assessment of dietary habits based on self-reported information about the monthly- weekly- or daily-frequency consumption of main food groups, including cereals and bread, meat, fish, fruit, vegetable, legumes, dairy products, sweets and snacks, drinks, and dietary supplements.

Assessment of gut microbiome composition on stool samples.