Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

March 11, 2022

Primary Completion Date

June 15, 2025

Study Completion Date

September 4, 2026

Conditions
Diffuse Astrocytoma, IDH-WildtypeRecurrent Glioblastoma
Interventions
BIOLOGICAL

Atezolizumab

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample and tumor tissue collection

PROCEDURE

Conventional Surgery

Undergo surgery

RADIATION

Fractionated Stereotactic Radiation Therapy

Undergo FSRT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Tocilizumab

Given IV

Trial Locations (110)

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

11794

Stony Brook University Medical Center, Stony Brook

15213

UPMC-Presbyterian Hospital, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

UPMC-Shadyside Hospital, Pittsburgh

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

Geisinger Cancer Services-Pottsville, Pottsville

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

19611

Reading Hospital, West Reading

22031

Inova Schar Cancer Institute, Fairfax

23114

Bon Secours Saint Francis Medical Center, Midlothian

23298

VCU Massey Comprehensive Cancer Center, Richmond

29425

Medical University of South Carolina, Charleston

32207

Baptist MD Anderson Cancer Center, Jacksonville

32806

Orlando Health Cancer Institute, Orlando

33176

Miami Cancer Institute, Miami

33486

Boca Raton Regional Hospital, Boca Raton

33612

Moffitt Cancer Center, Tampa

37232

Vanderbilt University/Ingram Cancer Center, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Riverside Methodist Hospital, Columbus

44195

Cleveland Clinic Foundation, Cleveland

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

53188

UW Cancer Center at ProHealth Care, Waukesha

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54481

Aspirus Cancer Care - Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54501

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

59405

Benefis Sletten Cancer Institute, Great Falls

59901

Logan Health Medical Center, Kalispell

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60612

Rush MD Anderson Cancer Center, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62801

Centralia Oncology Clinic, Centralia

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64132

Research Medical Center, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

67214

Ascension Via Christi Hospitals Wichita, Wichita

73104

University of Oklahoma Health Sciences Center, Oklahoma City

80045

UCHealth University of Colorado Hospital, Aurora

80524

Poudre Valley Hospital, Fort Collins

80528

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

Medical Center of the Rockies, Loveland

80631

UCHealth Greeley Hospital, Greeley

80909

UCHealth Memorial Hospital Central, Colorado Springs

80920

Memorial Hospital North, Colorado Springs

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

89502

Renown Regional Medical Center, Reno

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

90706

Kaiser Permanente-Bellflower, Bellflower

91761

Kaiser Permanente-Ontario, Ontario

92120

Kaiser Permanente-San Diego Zion, San Diego

92806

Kaiser Permanente-Anaheim, Anaheim

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94115

California Pacific Medical Center-Pacific Campus, San Francisco

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

97030

Legacy Mount Hood Medical Center, Gresham

97062

Legacy Meridian Park Hospital, Tualatin

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

98055

Valley Medical Center, Renton

98684

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver

98686

Legacy Salmon Creek Hospital, Vancouver

04102

MaineHealth Maine Medical Center - Portland, Portland

04073

MaineHealth Cancer Care Center of York County, Sanford

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

04106

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

01655

UMass Memorial Medical Center - University Campus, Worcester

07753

Jersey Shore Medical Center, Neptune City

07902

Overlook Hospital, Summit

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05401

University of Vermont Medical Center, Burlington

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH

NCT04729959 - Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma | Biotech Hunter | Biotech Hunter