Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

PHASE2RecruitingINTERVENTIONAL
Enrollment

490

Participants

Timeline

Start Date

April 5, 2021

Primary Completion Date

March 19, 2027

Study Completion Date

March 19, 2027

Conditions
Hematologic MalignanciesWaldenstroms MacroglobulinaemiaNon-Hodgkins LymphomaChronic Lymphocytic Leukaemia
Interventions
DRUG

Nemtabrutinib

Nemtabrutinib tablets administered orally QD.

Trial Locations (122)

1122

RECRUITING

Orszagos Onkologiai Intezet ( Site 1200), Budapest

2747

COMPLETED

Nepean Hospital-Nepean Cancer Care Centre ( Site 0204), Sydney

3010

RECRUITING

Inselspital Bern ( Site 2303), Bern

3128

RECRUITING

Box Hill Hospital ( Site 0203), Box Hill

4000

RECRUITING

Sjaellands Universitetshospital Roskilde ( Site 0701), Roskilde

4032

RECRUITING

Debreceni Egyetem Klinikai Kozpont ( Site 1201), Debrecen

4400

RECRUITING

Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1206), Nyíregyháza

5000

COMPLETED

Odense University Hospital ( Site 0705), Odense C

6009

RECRUITING

Sir Charles Gairdner Hospital ( Site 0200), Nedlands

6500

RECRUITING

Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 2302), Bellinzona

7624

RECRUITING

Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar ( Site 1202), Pécs

8200

COMPLETED

Aarhus University Hospital ( Site 0702), Aarhus N

9000

RECRUITING

Aalborg Universitetshospital ( Site 0703), Aalborg

13009

RECRUITING

Institut Paoli-Calmettes ( Site 0803), Marseille

15006

RECRUITING

CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2005), A Coruña

18009

RECRUITING

MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2509), Cherkassy

20132

RECRUITING

IRCCS Ospedale San Raffaele ( Site 1402), Milan

25123

RECRUITING

ASST Spedali Civili di Brescia ( Site 1408), Brescia

27100

RECRUITING

Fondazione IRCCS Policlinico San Matteo ( Site 1407), Pavia

28041

RECRUITING

Hospital Universitario 12 de Octubre ( Site 2003), Madrid

28222

RECRUITING

Hospital Puerta de Hierro ( Site 2009), Madrid

34214

RECRUITING

Mega Medipol-Hematology ( Site 2406), Stanbul

34365

COMPLETED

VKV Amerikan Hastanesi ( Site 2403), Istanbul

34381

RECRUITING

Sisli Florence Nightingale Hastanesi ( Site 2407), Istanbul

35340

RECRUITING

Dokuz Eylül Üniversitesi-Hematology ( Site 2402), Izmir

37007

RECRUITING

Hospital Universitario de Salamanca ( Site 2002), Salamanca

40138

RECRUITING

A.O. Universitaria Policlinico S. Orsola-Malpighi ( Site 1400), Bologna

40202

RECRUITING

The University of Louisville, James Graham Brown Cancer Center ( Site 2729), Louisville

42123

RECRUITING

IRCCS - Arcispedale Santa Maria Nuova ( Site 1405), Reggio Emilia

50937

RECRUITING

Universitaetsklinikum Koeln ( Site 0901), Cologne

55905

RECRUITING

Mayo Clinic - Rochester ( Site 2706), Rochester

57072

COMPLETED

St. Marien-Krankenhaus Siegen ( Site 0914), Siegen

58122

COMPLETED

Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708), Fargo

69495

RECRUITING

Centre Hospitalier Lyon-Sud ( Site 0804), Pierre-Bénite

70124

RECRUITING

Istituto Tumori Giovanni Paolo II ( Site 1409), Bari

72762

RECRUITING

Highlands Oncology Group ( Site 2728), Springdale

75010

RECRUITING

Hopital Saint Louis ( Site 0805), Paris

75390

RECRUITING

UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730), Dallas

76008

COMPLETED

"Communal non-profit enterprise Regional clinical hospital o-Hematology Department ( Site 2510)", Ivano-Frankivsk

76100

RECRUITING

Kaplan Medical Center ( Site 1304), Rehovot

78150

RECRUITING

Centre Hospitalier de Versailles ( Site 0809), Le Chesnay

79044

RECRUITING

Instit. of Blood Transfusion Medicine of the National Academy ( Site 2506), Lviv

80131

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1403), Napoli

80218

RECRUITING

Colorado Blood Cancer Institute ( Site 2726), Denver

89081

RECRUITING

Universitaetsklinikum Ulm. ( Site 0906), Ulm

90502

RECRUITING

Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724), Torrance

99208

RECRUITING

Medical Oncology Associates (Summit Cancer Centers) ( Site 2710), Spokane

100191

RECRUITING

Peking University Third Hospital-Hematology ( Site 2827), Beijing

130021

RECRUITING

The First Hospital of Jilin University-Hematology ( Site 2803), Changchun

200032

RECRUITING

Fudan University Shanghai Cancer Center ( Site 2801), Shanghai

200040

RECRUITING

Huashan Hospital, Fudan University ( Site 2821), Shanghai

210029

RECRUITING

Jiangsu Province Hospital ( Site 2823), Nanjing

221000

RECRUITING

The Affiliated Hospital of Xuzhou Medical College ( Site 2818), Xuzhou

230071

RECRUITING

Anhui Provincial Hospital ( Site 2808), Hefei

301617

RECRUITING

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Unio ( Site 2800), Tianjin

310002

RECRUITING

The First Affiliated Hospital, Zhejiang University ( Site 2826), Hangzhou

330006

RECRUITING

The First Affiliated Hospital of Nanchang University ( Site 2815), Nanchang

400072

RECRUITING

The Second Affiliated Hospital of Chongqing Medical University ( Site 2825), Chongqing

410011

RECRUITING

The Second Xiangya Hospital of Central South University ( Site 2820), Changsha

410013

RECRUITING

Hunan Cancer Hospital ( Site 2822), Changsha

430022

RECRUITING

Wuhan Union Hospital ( Site 2816), Wuhan

450008

RECRUITING

Henan Cancer Hospital-hematology department ( Site 2802), Zhengzhou

500052

RECRUITING

Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 1802), Brasov

510060

RECRUITING

Sun Yat-sen University Cancer Center-Internal Medicine ( Site 2824), Guangzhou

530201

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital ( Site 2814), Nanning

545006

RECRUITING

Guangxi Medical University - Liuzhou Renmin Hospital ( Site 2817), Liuzhou

610041

RECRUITING

West China Hospital Sichuan University ( Site 2810), Chengdu

700483

RECRUITING

Institutul Regional de Oncologie Iasi ( Site 1801), Iași

905900

COMPLETED

Ovidius Clinical Hospital ( Site 1804), Ovidiu

1834111

RECRUITING

Ha Emek Medical Center ( Site 1305), Afula

3109601

RECRUITING

Rambam Medical Center ( Site 1301), Haifa

5262001

RECRUITING

Chaim Sheba Medical Center ( Site 1302), Ramat Gan

6423906

RECRUITING

Sourasky Medical Center ( Site 1303), Tel Aviv

8457108

RECRUITING

Soroka Medical Center ( Site 1307), Beersheba

9112001

RECRUITING

Hadassah Ein Karem Jerusalem ( Site 1300), Jerusalem

92093-0698

RECRUITING

University of California San Diego Moores Cancer Center ( Site 2717), La Jolla

08816

RECRUITING

Astera Cancer Care ( Site 2732), East Brunswick

07601

RECRUITING

John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704), Hackensack

C1118AAT

RECRUITING

Hospital Aleman ( Site 0102), Ciudad Autonoma de Buenos Aires

C1431FWO

RECRUITING

Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0103), Buenos Aires

S2000DEJ

RECRUITING

Fundacion Estudios Clinicos ( Site 0112), Rosario

C1114AAN

RECRUITING

FUNDALEU ( Site 0104), Caba

X5016KEH

RECRUITING

Hospital Privado Universitario de Córdoba ( Site 0107), Córdoba

M5500AYB

COMPLETED

Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0110), Mendoza

05403-000

RECRUITING

Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia ( Site 0303), São Paulo

20231-050

RECRUITING

Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0300), Rio de Janeiro

01321-001

COMPLETED

BP - A Beneficencia Portuguesa de São Paulo ( Site 0302), São Paulo

RECRUITING

Hospital Paulistano - Amil Clinical Research ( Site 0311), São Paulo

T2N 5G2

RECRUITING

Arthur J.E. Child Comprehensive Cancer Centre ( Site 0401), Calgary

K1H 8L6

RECRUITING

The Ottawa Hospital ( Site 0404), Ottawa

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0406), Toronto

H1T 2M4

RECRUITING

CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0403), Montreal

H3T 1E2

RECRUITING

Jewish General Hospital ( Site 0400), Montreal

625 00

RECRUITING

Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0600), Brno

500 05

RECRUITING

Fakultni nemocnice Hradec Kralove ( Site 0601), Hradec Králové

06202

RECRUITING

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0810), Nice

01307

RECRUITING

Universitaetsklinikum Carl Gustav Carus ( Site 0902), Dresden

Dublin 9

RECRUITING

Beaumont Hospital ( Site 2900), Dublin

V94 F858

RECRUITING

University Hospital Limerick ( Site 2903), Limerick

00161

COMPLETED

Policlinico Umberto I ( Site 1404), Roma

30-727

RECRUITING

Pratia MCM Krakow ( Site 1601), Krakow

50-367

RECRUITING

Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site 1606), Wroclaw

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1608), Warsaw

45-061

COMPLETED

Szpital Wojewódzki w Opolu-Hematology Department ( Site 1607), Opole

81-519

COMPLETED

Szpitale Pomorskie Sp. z o.o. ( Site 1600), Gdynia

030171

RECRUITING

Spitalul Clinic Colțea ( Site 1805), Bucharest

03722

RECRUITING

Severance Hospital Yonsei University Health System ( Site 2201), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 2200), Seoul

08908

RECRUITING

Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 2000), L'Hospitalet de Llobregat

03010

RECRUITING

Hospital General Universitario de Alicante ( Site 2007), Alicante

08035

RECRUITING

Hospital Universitari Vall d'Hebron ( Site 2001), Barcelona

06590

RECRUITING

Ankara Universitesi Tip Fakultesi Cebeci Hastanesi ( Site 2400), Ankara

03022

RECRUITING

National Cancer Institute ( Site 2507), Kyiv

04112

RECRUITING

Kyiv City Clinical Hospital 9 ( Site 2502), Kyiv

BS2 8ED

RECRUITING

Bristol Haematology and Oncology Centre ( Site 2610), Bristol

NG5 1PF

RECRUITING

Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 2601), Nottingham

SL4 3HD

RECRUITING

GenesisCare - Windsor ( Site 2608), Windsor

W1G 6AD

RECRUITING

Sarah Cannon Research Institute UK ( Site 2612), London

OX4 6LB

RECRUITING

GenesisCare - Oxford ( Site 2607), Oxford

CB8 7XN

RECRUITING

GenesisCare - Cambridge ( Site 2611), Newmarket

SM2 5PT

RECRUITING

The Royal Marsden NHS Foundation Trust. ( Site 2606), Sutton

M20 4BX

RECRUITING

The Christie NHS Foundation Trust ( Site 2602), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04728893 - Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) | Biotech Hunter | Biotech Hunter