165
Participants
Start Date
January 1, 2024
Primary Completion Date
May 1, 2026
Study Completion Date
January 1, 2027
Mirtazapine
Use of 3.75mg mirtazapine before lights-out during first 2 weeks after TKA surgery. With insufficient effect on sleep, patients are allowed to increase medication to 7.5mg mirtazapine.
Quetiapine
Use of 3.125mg quetiapine before lights-out during first 2 weeks after TKA surgery. With insufficient effect on sleep, patients are allowed to increase medication to 6.25mg mirtazapine.
Placebo
a gelatinous capsule without an active ingredient
Knowledge Center for Orthopedic Surgery, St. Anna hospital, Geldrop
St. Anna hospital, Geldrop
St. Anna Ziekenhuis, Geldrop, Netherlands
OTHER