2,000
Participants
Start Date
August 1, 2018
Primary Completion Date
August 31, 2028
Study Completion Date
August 31, 2050
Methotrexate
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Sulfasalazine
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Leflunomide
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Pamidronate
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Zoledronic acid
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Etanercept
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Adalimumab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Certolizumab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Infliximab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
Golimumab
second-line treatment for children with CNO/CRMO after failure to respond to NSAIDs
NSAID
first-line treatment
RECRUITING
Seattle Children's Hospital, Seattle
Boston Children's Hospital, Boston, MA, USA
OTHER
Hospital for Special Surgery, New York
OTHER
Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ, USA
UNKNOWN
Riley Children's Hospital, Indianapolis, IN, USA
UNKNOWN
University of North Carolina, Chapel Hill, NC, USA
UNKNOWN
Royal Children's Hospital
OTHER
Hacettepe University, Ankara, Turkey
UNKNOWN
Bambino Gesù Children's Hospital, Rome, Italy
UNKNOWN
University of British Columbia, Vancouver, BC, Canada
UNKNOWN
Meyer Children's Hospital, Florence, Italy
UNKNOWN
Mansoura University
OTHER
University of Utah, Salt Lake City, UT, USA
UNKNOWN
University of Iowa Carver College of Medicine, Iowa City, IA, USA
UNKNOWN
Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA
UNKNOWN
Palacky University Olomouc Institute of Molecular and Translational Medicine, Olomouc, Czechia
UNKNOWN
Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK
UNKNOWN
University of Calgary, Calgary, Alberta, Canada
UNKNOWN
Seattle Children's Hospital
OTHER