An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With SoC, Versus SoC Alone, in Adult Male Patients With mHSPC

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,145

Participants

Timeline

Start Date

June 9, 2021

Primary Completion Date

January 13, 2025

Study Completion Date

February 11, 2027

Conditions
Prostatic Neoplasms
Interventions
DRUG

177Lu-PSMA-617

administered intravenously once every 6 weeks (1 cycle) for 6 cycles

DRUG

68Ga-PSMA-11

Intravenous dose of approx. 150 Megabecquerel (MBq) at screening and at time of centrally confirmed rPD

DRUG

ARDT

Administered orally on a continuous basis as per package insert and guideline

DRUG

ADT

ADT are administered as per physician order

Trial Locations (166)

1011

Novartis Investigative Site, Lausanne

1090

Novartis Investigative Site, Vienna

1200

Novartis Investigative Site, Brussels

3010

Novartis Investigative Site, Bern

4020

Novartis Investigative Site, Linz

6020

Novartis Investigative Site, Innsbruck

9000

Novartis Investigative Site, Ghent

10002

Novartis Investigative Site, Taipei

10021

Weill Cornell Medical College, New York

10065

Memorial Sloan Kettering Cancer Ctr, New York

10467

Montefiore Medical Center, The Bronx

14642

Univ Of Rochester Cancer Ctr, Rochester

15232

Univ of Pittsburgh Cancer Institute, Pittsburgh

17033

Penn State Hershey Medical Center, Hershey

17176

Novartis Investigative Site, Stockholm

18057

Novartis Investigative Site, Rostock

19107

Thomas Jefferson Univ Hosp, Philadelphia

20007

Georgetown University-Lombardi Cancer Center, Washington D.C.

20422

VA Medical Center, Washington D.C.

21231

Sidney Kimmel CCC At JH, Baltimore

22908

University of Virginia Medical Center, Charlottesville

23502

Virginia Oncology Associates, Norfolk

24014

Onco Hemato Asso of SE Virginia, Roanoke

27710

Duke Univ Medical Center, Durham

28034

Novartis Investigative Site, Madrid

28040

Novartis Investigative Site, Madrid

28041

Novartis Investigative Site, Madrid

28046

Novartis Investigative Site, Madrid

28203

Levine Cancer Institute, Charlotte

28222

Novartis Investigative Site, Madrid

29572

Carolina Urologic Research Center, Myrtle Beach

30120

Novartis Investigative Site, El Palmar

30607

University Cancer and Blood Center LLC, Athens

32224

Mayo Clinic Jacksonville, Jacksonville

32256

Cancer Specialists of North Florida, Jacksonville

32405

Florida Cancer Affiliates, Panama City

33075

Novartis Investigative Site, Bordeaux

33136

University Of Miami, Miami

33173

Baptist Health Medical Group, Miami

33305

Novartis Investigative Site, Taoyuan District

34298

Novartis Investigative Site, Montpellier

39216

University of Mississippi Med Ctr, Jackson

43221

The Ohio State University Comprehensive Cancer Center, Columbus

44093

Novartis Investigative Site, Nantes

44195

Cleveland Clinic Foundation, Cleveland

45147

Novartis Investigative Site, Essen

46026

Novartis Investigative Site, Valencia

46202

Indiana University, Indianapolis

46845

Parkview Research Center, Fort Wayne

48109

Uni Of Michigan Health System, Ann Arbor

48149

Novartis Investigative Site, Münster

50937

Novartis Investigative Site, Cologne

53226

Medical College Of Wisconsin, Milwaukee

54511

Novartis Investigative Site, Vandœuvre-lès-Nancy

55455

University of Minnesota, Minneapolis

55905

Mayo Clinic Rochester, Rochester

Mayo Clinic, Rochester

60141

Hines VA Hospital, Hines

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

60637

University of Chicago, Chicago

63011

Novartis Investigative Site, Clermont-Ferrand

63104

St. Louis University, St Louis

63106

VA St Louis Health Care System, St Louis

63110

Wash U School of Medicine, St Louis

67200

Novartis Investigative Site, Strasbourg

68130

Nebraska Cancer Specialists, Omaha

Urology Cancer Center PC, Omaha

69373

Novartis Investigative Site, Lyon

70112

Tulane Cancer Center, New Orleans

70121

Ochsner Clinic Foundation, New Orleans

75015

Novartis Investigative Site, Paris

75018

Novartis Investigative Site, Paris

75216

Dallas VA Medical Center, Dallas

75246

Texas Oncology, Dallas

77030

MD Anderson, Houston

UT Health Science Center, Houston

78229

UT Health San Antonio Mays Cancer Center, San Antonio

80045

Univ Of Color Anschutz Med Center, Aurora

80218

Rocky Mountain Cancer Centers, Denver

80377

Novartis Investigative Site, München

85259

Mayo Clinic - Arizona Mayo Clinic Hospital, Scottsdale

Mayo Clinic Arizona, Scottsdale

90073

VA Greater LA Healthcare System, Los Angeles

90095

University of California LA, Los Angeles

90404

Providence Saint Johns Health Ctr, Santa Monica

92686

St. Joseph Hospital, Orange

92868

Univ Cali Irvine ALS Neuromuscular, Orange

93105

Sansum Clinic, Santa Barbara

94304

Stanford University Medical Center, Palo Alto

94800

Novartis Investigative Site, Villejuif

96813

The Queens Medical Centre, Honolulu

97080

Novartis Investigative Site, Würzburg

97239

Oregon Health Sciences University, Portland

100036

Novartis Investigative Site, Beijing

119228

Novartis Investigative Site, Singapore

168583

Novartis Investigative Site, Singapore

200025

Novartis Investigative Site, Shanghai

200032

Novartis Investigative Site, Shanghai

200080

Novartis Investigative Site, Shanghai

210006

Novartis Investigative Site, Nanjing

210029

Novartis Investigative Site, Nanjing

300308

Novartis Investigative Site, Tianjin

510060

Novartis Investigative Site, Guangzhou

610041

Novartis Investigative Site, Chengdu

710032

Novartis Investigative Site, Xian

92093-0658

University of California San Diego - Moores Cancer Center, La Jolla

94304-1207

VA Palo Alto Health Care System, Palo Alto

06102

Hartford Hospital, Hartford

02115

Dana Farber Cancer Institute, Boston

48073-6769

Corewell Health William Beaum Hosp, Royal Oak

87131 0001

University of New Mexico, Albuquerque

75390-9034

Univ of Texas Southwest Med Center, Dallas

98122-4379

Swedish Medical Center, Seattle

V5Z 1M9

Novartis Investigative Site, Vancouver

L8V 5C2

Novartis Investigative Site, Hamilton

M4N 3M5

Novartis Investigative Site, Toronto

H2W 1T8

Novartis Investigative Site, Montreal

H3T 1E2

Novartis Investigative Site, Montreal

H4A 3J1

Novartis Investigative Site, Montreal

G1R 2J6

Novartis Investigative Site, Québec

J1H 5N4

Novartis Investigative Site, Sherbrooke

779 00

Novartis Investigative Site, Olomouc

150 06

Novartis Investigative Site, Prague

DK-2100

Novartis Investigative Site, Copenhagen

466 8560

Novartis Investigative Site, Nagoya

812-8582

Novartis Investigative Site, Fukuoka

960 1295

Novartis Investigative Site, Fukushima

060 8648

Novartis Investigative Site, Sapporo

650-0047

Novartis Investigative Site, Kobe

236-0004

Novartis Investigative Site, Yokohama

700-8558

Novartis Investigative Site, Okayama

565 0871

Novartis Investigative Site, Suita

362-0806

Novartis Investigative Site, Kitaadachi-gun

113-8431

Novartis Investigative Site, Bunkyo Ku

104 0045

Novartis Investigative Site, Chuo Ku

260-8717

Novartis Investigative Site, Chiba

811-0213

Novartis Investigative Site, Fukuoka

812-0033

Novartis Investigative Site, Fukuoka

860-8556

Novartis Investigative Site, Kumamoto

606 8507

Novartis Investigative Site, Kyoto

990 9585

Novartis Investigative Site, Yamagata

6500HB

Novartis Investigative Site, Nijmegen

6229 HX

Novartis Investigative Site, Maastricht

2625 AD

Novartis Investigative Site, Delft

3584 CX

Novartis Investigative Site, Utrecht

44-101

Novartis Investigative Site, Gliwice

31-501

Novartis Investigative Site, Krakow

02-781

Novartis Investigative Site, Warsaw

03080

Novartis Investigative Site, Seoul

03722

Novartis Investigative Site, Seoul

05505

Novartis Investigative Site, Seoul

08907

Novartis Investigative Site, L'Hospitalet de Llobregat

08208

Novartis Investigative Site, Sabadell

08035

Novartis Investigative Site, Barcelona

08036

Novartis Investigative Site, Barcelona

413 45

Novartis Investigative Site, Gothenburg

221 85

Novartis Investigative Site, Lund

SM2 5PT

Novartis Investigative Site, Sutton

BT9 7AB

Novartis Investigative Site, Belfast

CB2 0QQ

Novartis Investigative Site, Cambridge

G12 0YN

Novartis Investigative Site, Glasgow

EC1A 7BE

Novartis Investigative Site, London

NW1 2BU

Novartis Investigative Site, London

NW3 2QG

Novartis Investigative Site, London

TS4 3BW

Novartis Investigative Site, Middlesbrough

Sponsors
All Listed Sponsors
collaborator

Alliance Foundation Trials, LLC.

OTHER

collaborator

RTOG Foundation, Inc.

OTHER

lead

Novartis Pharmaceuticals

INDUSTRY