A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype

PHASE3CompletedINTERVENTIONAL
Enrollment

1,719

Participants

Timeline

Start Date

January 26, 2021

Primary Completion Date

September 14, 2025

Study Completion Date

September 14, 2025

Conditions
Asthma
Interventions
BIOLOGICAL

GSK3511294 (Depemokimab)

GSK3511294 (Depemokimab) will be provided in a single-use prefilled syringe (PFS).

BIOLOGICAL

Mepolizumab

Mepolizumab will be provided in a single-use PFS.

BIOLOGICAL

Benralizumab

Benralizumab will be provided in a single-use PFS.

BIOLOGICAL

Placebo

Placebo will be a sterile liquid formulation.

DRUG

Standard of care (SoC)

Non-biologic SoC will include inhaled corticosteroid (ICS) plus at least one other controller, long-acting beta-2-agonist (LABA), long-acting muscarinic antagonist (LAMA), with or without maintenance oral corticosteroids (OCS).

DEVICE

Pre-filled Syringes (PFS)

PFS will include glass barrel with pre-staked needle and plunger.

Trial Locations (397)

100

GSK Investigational Site, Taipei

168

GSK Investigational Site, Roma

220

GSK Investigational Site, Banchiau Taipei

333

GSK Investigational Site, Linkou - Taoyuan Hsien

404

GSK Investigational Site, Taichung

500

GSK Investigational Site, Changhua

1130

GSK Investigational Site, Vienna

1478

GSK Investigational Site, Lrenskog

2010

GSK Investigational Site, Sydney

2109

GSK Investigational Site, Macquarie Park

2145

GSK Investigational Site, Westmead

3065

GSK Investigational Site, Fitzroy

3128

GSK Investigational Site, Box Hill

3168

GSK Investigational Site, Clayton

3181

GSK Investigational Site, Melbourne

3199

GSK Investigational Site, Frankston

4031

GSK Investigational Site, Basel

4101

GSK Investigational Site, South Brisbane

4204

GSK Investigational Site, Golnik

4410

GSK Investigational Site, Liestal

4870

GSK Investigational Site, Cairns

5000

GSK Investigational Site, Adelaide

5001

GSK Investigational Site, Aarau

5006

GSK Investigational Site, North Adelaide

5011

GSK Investigational Site, Woodville

5021

GSK Investigational Site, Bergen

5042

GSK Investigational Site, Bedford Park

5065

GSK Investigational Site, Toorak Gardens

6009

GSK Investigational Site, Nedlands

7100

GSK Investigational Site, Sassari

8025

GSK Investigational Site, Barcelona

8330

GSK Investigational Site, Feldbach

9007

GSK Investigational Site, Sankt Gallen

10128

GSK Investigational Site, Torino

10467

GSK Investigational Site, The Bronx

10969

GSK Investigational Site, Berlin

11040

GSK Investigational Site, Great Neck

11215

GSK Investigational Site, Brooklyn

11407

GSK Investigational Site, Jerez de la Frontera

12159

GSK Investigational Site, Berlin

12203

GSK Investigational Site, Berlin

12540

GSK Investigational Site, Via-Real CastellOn

13015

GSK Investigational Site, Marseille

14033

GSK Investigational Site, Caen

14845

GSK Investigational Site, Corning

15241

GSK Investigational Site, Pittsburgh

15517

GSK Investigational Site, Fürstenwalde

15706

GSK Investigational Site, Santiago de Compostela

15801

GSK Investigational Site, Altoona

16132

GSK Investigational Site, Genova

16601

GSK Investigational Site, Altoona

17033

GSK Investigational Site, Hershey

18014

GSK Investigational Site, Granada

19140

GSK Investigational Site, Philadelphia

19610

GSK Investigational Site, Wyomissing

20122

GSK Investigational Site, Milan

20123

GSK Investigational Site, Milan

20132

GSK Investigational Site, Milan

20162

GSK Investigational Site, Milan

20354

GSK Investigational Site, Hamburg

20521

GSK Investigational Site, Turku

20815

GSK Investigational Site, Chevy Chase

21079

GSK Investigational Site, Dijon

21162

GSK Investigational Site, Baltimore

21224

GSK Investigational Site, Baltimore

21502

GSK Investigational Site, Geesthacht

23188

GSK Investigational Site, Williamsburg

23298

GSK Investigational Site, Richmond

23552

GSK Investigational Site, Lübeck

23558

GSK Investigational Site, Lübeck

24127

GSK Investigational Site, Bergamo

24837

GSK Investigational Site, Schleswig

25030

GSK Investigational Site, Besançon

25123

GSK Investigational Site, Brescia

27100

GSK Investigational Site, Pavia

27103

GSK Investigational Site, Winston-Salem

27157

GSK Investigational Site, Winston-Salem

28031

GSK Investigational Site, Madrid

28040

GSK Investigational Site, Madrid

28041

GSK Investigational Site, Madrid

28046

GSK Investigational Site, Madrid

28078

GSK Investigational Site, Huntersville

28223

GSK Investigational Site, Pozuelo de AlarcOn Madr

28401

GSK Investigational Site, Wilmington

28803

GSK Investigational Site, Asheville

28922

GSK Investigational Site, Alcorcón

29010

GSK Investigational Site, Málaga

29303

GSK Investigational Site, Spartanburg

29609

GSK Investigational Site, Brest

29631

GSK Investigational Site, Benalmádena

29732

GSK Investigational Site, Rock Hill

30625

GSK Investigational Site, Hanover

30701

GSK Investigational Site, Calhoun

31008

GSK Investigational Site, Pamplona

31059

GSK Investigational Site, Toulouse

31100

GSK Investigational Site, Treviso

32209

GSK Investigational Site, Jacksonville

32308

GSK Investigational Site, Tallahassee

32610

GSK Investigational Site, Gainesville

32803

GSK Investigational Site, Orlando

32806

GSK Investigational Site, Orlando

32819

GSK Investigational Site, Orlando

33014

GSK Investigational Site, Hialeah

GSK Investigational Site, Miami Lakes

33016

GSK Investigational Site, Hialeah

33125

GSK Investigational Site, Miami

GSK Investigational Site, Miami Lakes

33126

GSK Investigational Site, Miami

33144

GSK Investigational Site, Miami

33166

GSK Investigational Site, Miami

33172

GSK Investigational Site, Miami

33180

GSK Investigational Site, Aventura

33186

GSK Investigational Site, Miami

33316

GSK Investigational Site, Fort Lauderdale

33408

GSK Investigational Site, North Palm Beach

33470

GSK Investigational Site, Loxahatchee Groves

33520

GSK Investigational Site, Tampere

33870

GSK Investigational Site, Sebring

34139

GSK Investigational Site, Trieste

34295

GSK Investigational Site, Montpellier

34362

GSK Investigational Site, Haifa

34746

GSK Investigational Site, Kissimmee

35128

GSK Investigational Site, Padua

35209

GSK Investigational Site, Birmingham

35768

GSK Investigational Site, Scottsboro

36608

GSK Investigational Site, Gulfport

37007

GSK Investigational Site, Salamanca

37044

GSK Investigational Site, Tours

37075

GSK Investigational Site, Hendersonville

37134

GSK Investigational Site, Verona

37909

GSK Investigational Site, Knoxville

38320

GSK Investigational Site, La Laguna Santa Cruz

38700

GSK Investigational Site, La Tronche

39008

GSK Investigational Site, Santander

39120

GSK Investigational Site, Magdeburg

39216

GSK Investigational Site, Jackson

40138

GSK Investigational Site, Bologna

40509

GSK Investigational Site, Lexington

40705

GSK Investigational Site, Taichung

41124

GSK Investigational Site, Modena

42100

GSK Investigational Site, Reggio Emilia

42301

GSK Investigational Site, Owensboro

44093

GSK Investigational Site, Saint-Herblain

44124

GSK Investigational Site, Ferrara

44281

GSK Investigational Site, Kfar Saba

45229

GSK Investigational Site, Cincinnati

45231

GSK Investigational Site, Cincinnati

46015

GSK Investigational Site, Valencia

46017

GSK Investigational Site, Valencia

46100

GSK Investigational Site, Mantova

47715

GSK Investigational Site, Evansville

48013

GSK Investigational Site, Bilbao

48088

GSK Investigational Site, Warren

48109

GSK Investigational Site, Ann Arbor

48431

GSK Investigational Site, Rheine

48507

GSK Investigational Site, Flint

49100

GSK Investigational Site, Petah Tikva

49300

GSK Investigational Site, Cholet

50009

GSK Investigational Site, Zaragoza

50134

GSK Investigational Site, Florence

52621

GSK Investigational Site, Ramat Gan

53100

GSK Investigational Site, Siena

53119

GSK Investigational Site, Bonn

53127

GSK Investigational Site, Bonn

53228

GSK Investigational Site, Greenfield

55128

GSK Investigational Site, Mainz

55454

GSK Investigational Site, Minneapolis

56100

GSK Investigational Site, Pisa

56170

GSK Investigational Site, Bendorf

59037

GSK Investigational Site, Lille

60020

GSK Investigational Site, Torrette AN

60077

GSK Investigational Site, Glenview

60301

GSK Investigational Site, New York

60389

GSK Investigational Site, Frankfurt

60596

GSK Investigational Site, Frankfurt

63017

GSK Investigational Site, Chesterfield

63110

GSK Investigational Site, St Louis

63263

GSK Investigational Site, Neu-Isenburg

63301

GSK Investigational Site, Saint Charles

63739

GSK Investigational Site, Aschaffenburg

64239

GSK Investigational Site, Tel Aviv

64283

GSK Investigational Site, Darmstadt

66210

GSK Investigational Site, Overland Park

67091

GSK Investigational Site, Strasbourg

68505

GSK Investigational Site, Lincoln

69317

GSK Investigational Site, Lyon

70124

GSK Investigational Site, Bari

70300

GSK Investigational Site, Zrifin

72037

GSK Investigational Site, Le Mans

74011

GSK Investigational Site, Annecy

75014

GSK Investigational Site, Paris

75015

GSK Investigational Site, Paris

75225

GSK Investigational Site, Dallas

75235

GSK Investigational Site, Dallas

75246

GSK Investigational Site, Dallas

75877

GSK Investigational Site, Paris

76031

GSK Investigational Site, Rouen

76290

GSK Investigational Site, Montivilliers

77030

GSK Investigational Site, Houston

77429

GSK Investigational Site, Houston

78028

GSK Investigational Site, Kerrville

78207

GSK Investigational Site, San Antonio

78229

GSK Investigational Site, San Antonio

78258

GSK Investigational Site, San Antonio

79106

GSK Investigational Site, Amarillo

79124

GSK Investigational Site, Amarillo

80000

GSK Investigational Site, Amiens

80033

GSK Investigational Site, Wheat Ridge

80131

GSK Investigational Site, Napoli

80209

GSK Investigational Site, Denver

80238

GSK Investigational Site, Aurora

80907

GSK Investigational Site, Colorado Springs

80923

GSK Investigational Site, Colorado Springs

81241

GSK Investigational Site, München

84107

GSK Investigational Site, Murray

84131

GSK Investigational Site, Salerno

85054

GSK Investigational Site, Phoenix

85251

GSK Investigational Site, Scottsdale

85340

GSK Investigational Site, Litchfield Park

86899

GSK Investigational Site, Landsberg

90048

GSK Investigational Site, Los Angeles

90127

GSK Investigational Site, Palermo

90277

GSK Investigational Site, Redondo Beach

91031

GSK Investigational Site, Jerusalem

91120

GSK Investigational Site, Jerusalem

91324

GSK Investigational Site, Valencia

91730

GSK Investigational Site, Rancho Cucamonga

91786

GSK Investigational Site, Riverside

92024

GSK Investigational Site, Encinitas

92123

GSK Investigational Site, San Diego

92150

GSK Investigational Site, Suresnes

92160

GSK Investigational Site, Antony

92307

GSK Investigational Site, San Diego

92647

GSK Investigational Site, Huntington Beach

92663

GSK Investigational Site, Newport Beach

93036

GSK Investigational Site, Oxnard

93301

GSK Investigational Site, Bakersfield

93370

GSK Investigational Site, Montfermeil

94063

GSK Investigational Site, Redwood City

95123

GSK Investigational Site, Catania

95303

GSK Investigational Site, Pontoise

95695

GSK Investigational Site, Woodland

97330

GSK Investigational Site, Corvallis

98115

GSK Investigational Site, Seattle

98225

GSK Investigational Site, Bellingham

8410101

GSK Investigational Site, Beersheba

06511

GSK Investigational Site, New Haven

33765-2103

GSK Investigational Site, Clearwater

04401

GSK Investigational Site, Bangor

02115

GSK Investigational Site, Boston

01805

GSK Investigational Site, Burlington

02740

GSK Investigational Site, New Bedford

02747

GSK Investigational Site, North Dartmouth

68198-5990

GSK Investigational Site, Omaha

08724

GSK Investigational Site, Brick

08225

GSK Investigational Site, Northfield

07457

GSK Investigational Site, Riverdale

08755

GSK Investigational Site, Toms River

10459-2417

GSK Investigational Site, The Bronx

02886

GSK Investigational Site, Warwick

T2N 4Z6

GSK Investigational Site, Calgary

T5J 3S9

GSK Investigational Site, Edmonton

E1C 5K4

GSK Investigational Site, Moncton

L1S 2J5

GSK Investigational Site, Ajax

K1H 1E4

GSK Investigational Site, Ottawa

M5G 1E2

GSK Investigational Site, Toronto

M5T 3A9

GSK Investigational Site, Toronto

N8X 1T3

GSK Investigational Site, Windsor

J4V 2H1

GSK Investigational Site, Greenfield Park

G1V 4G5

GSK Investigational Site, Québec

G1V 4W2

GSK Investigational Site, Québec

G8T 7A1

GSK Investigational Site, Trois-Rivières

06414

GSK Investigational Site, Cannes

13003.

GSK Investigational Site, Marseille

06001

GSK Investigational Site, Nice

06108

GSK Investigational Site, Halle

06120

GSK Investigational Site, Halle

04207

GSK Investigational Site, Leipzig

04275

GSK Investigational Site, Leipzig

04347

GSK Investigational Site, Leipzig

T12 DFK4

GSK Investigational Site, Cork

D04 T6F4

GSK Investigational Site, Dublin

D08 NHY1

GSK Investigational Site, Dublin

09042

GSK Investigational Site, Monserrato CA

06156

GSK Investigational Site, Perugia

150-8935

GSK Investigational Site, Shibuya-Ku

454-8509

GSK Investigational Site, Aichi

470-1192

GSK Investigational Site, Aichi

489-8642

GSK Investigational Site, Aichi

010-8543

GSK Investigational Site, Akita

790-0024

GSK Investigational Site, Ehime

802-0052

GSK Investigational Site, Fukuoka

805-8508

GSK Investigational Site, Fukuoka

806-8501

GSK Investigational Site, Fukuoka

811-1394

GSK Investigational Site, Fukuoka

813-0017

GSK Investigational Site, Fukuoka

830-0011

GSK Investigational Site, Fukuoka

960-1295

GSK Investigational Site, Fukushima

509-6134

GSK Investigational Site, Gifu

734-8530

GSK Investigational Site, Hiroshima

735-8585

GSK Investigational Site, Hiroshima

737-0023

GSK Investigational Site, Hiroshima

064-0804

GSK Investigational Site, Hokkaido

650-0047

GSK Investigational Site, Hyōgo

653-0013

GSK Investigational Site, Hyōgo

302-0022

GSK Investigational Site, Ibaraki

319-1113

GSK Investigational Site, Ibaraki

920-0293

GSK Investigational Site, Ishikawa

762-8550

GSK Investigational Site, Kagawa

890-8520

GSK Investigational Site, Kagoshima

231-8682

GSK Investigational Site, Kanagawa

232-0024

GSK Investigational Site, Kanagawa

236-0004

GSK Investigational Site, Kanagawa

236-0051

GSK Investigational Site, Kanagawa

254-8502

GSK Investigational Site, Kanagawa

510-8561

GSK Investigational Site, Mie

511-0061

GSK Investigational Site, Mie

515-8544

GSK Investigational Site, Mie

981-8563

GSK Investigational Site, Miyagi

386-8610

GSK Investigational Site, Nagano

951-8520

GSK Investigational Site, Niigata

020-8505

GSK Investigational Site, Numakunai

701-0304

GSK Investigational Site, Okayama

702-8055

GSK Investigational Site, Okayama

530-0012

GSK Investigational Site, Osaka

543-8555

GSK Investigational Site, Osaka

560-8552

GSK Investigational Site, Osaka

569-1096

GSK Investigational Site, Osaka

569-1192

GSK Investigational Site, Osaka

569-8686

GSK Investigational Site, Osaka

572-8551

GSK Investigational Site, Osaka

593-8304

GSK Investigational Site, Osaka

596-8501

GSK Investigational Site, Osaka

693-8501

GSK Investigational Site, Shimane

420-8527

GSK Investigational Site, Shizuoka

430-8525

GSK Investigational Site, Shizuoka

103-0027

GSK Investigational Site, Tokyo

105-8471

GSK Investigational Site, Tokyo

113-8431

GSK Investigational Site, Tokyo

113-8519

GSK Investigational Site, Tokyo

136-0075

GSK Investigational Site, Tokyo

141-8625

GSK Investigational Site, Tokyo

142-8666

GSK Investigational Site, Tokyo

160-8582

GSK Investigational Site, Tokyo

162-8655

GSK Investigational Site, Tokyo

173-8606

GSK Investigational Site, Tokyo

187-8510

GSK Investigational Site, Tokyo

190-0014

GSK Investigational Site, Tokyo

204-8585

GSK Investigational Site, Tokyo

930-8550

GSK Investigational Site, Toyama

640-8558

GSK Investigational Site, Wakayama

6815 AD

GSK Investigational Site, Arnhem

4818 CK

GSK Investigational Site, Breda

7416 SE

GSK Investigational Site, Deventer

5623 EJ

GSK Investigational Site, Eindhoven

7513 ER

GSK Investigational Site, Enschede

3844 DG

GSK Investigational Site, Harderwijk

8934 AD

GSK Investigational Site, Leeuwarden

6532 SZ

GSK Investigational Site, Nijmegen

3045 PM

GSK Investigational Site, Rotterdam

8025 AB

GSK Investigational Site, Zwolle

3041-801

GSK Investigational Site, Coimbra

6300-035

GSK Investigational Site, Guarda

1649-035

GSK Investigational Site, Lisbon

4464-509

GSK Investigational Site, Matosinhos Municipality

00968

GSK Investigational Site, Guaynabo

04009

GSK Investigational Site, Almería

08916

GSK Investigational Site, Badalona

08003

GSK Investigational Site, Barcelona

08017

GSK Investigational Site, Barcelona

08035

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

08950

GSK Investigational Site, Barcelona

06800

GSK Investigational Site, MErida Badajoz

01009

GSK Investigational Site, Vitoria-Gasteiz

SE-58758

GSK Investigational Site, Linköping

SE-221 85

GSK Investigational Site, Lund

SE-831 83

GSK Investigational Site, Östersund

SE-141 86

GSK Investigational Site, Stockholm

SE-751 85

GSK Investigational Site, Uppsala

BT9 7AB

GSK Investigational Site, Belfast

B9 5SS

GSK Investigational Site, Birmingham

BD9 6RJ

GSK Investigational Site, Bradford

BS10 5NB

GSK Investigational Site, Bristol Avon

HU16 5JQ

GSK Investigational Site, Cottingham

EX2 5DW

GSK Investigational Site, Exeter

G31 2ER

GSK Investigational Site, Glasgow

G51 4TF

GSK Investigational Site, Glasgow

L7 8XP

GSK Investigational Site, Liverpool

EC1A 7BE

GSK Investigational Site, London

NE7 7DN

GSK Investigational Site, Newcastle upon Tyne

NG5 1PB

GSK Investigational Site, Nottingham

OX3 9DU

GSK Investigational Site, Oxford

PO6 3LY

GSK Investigational Site, Portsmouth

PR2 9HT

GSK Investigational Site, Preston

WF1 4DG

GSK Investigational Site, Wakefield

ML6 0JS

GSK Investigational Site, Wishaw

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Iqvia Pty Ltd

INDUSTRY

lead

GlaxoSmithKline

INDUSTRY

NCT04718389 - A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype | Biotech Hunter | Biotech Hunter